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Q4UK16 (ATPA_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP synthase subunit alpha

EC=3.6.3.14
Alternative name(s):
ATP synthase F1 sector subunit alpha
F-ATPase subunit alpha
Gene names
Name:atpA
Ordered Locus Names:RF_1268
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity. HAMAP-Rule MF_01346

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP-Rule MF_01346

Subunit structure

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_01346.

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 510510ATP synthase subunit alpha HAMAP-Rule MF_01346
PRO_0000238344

Regions

Nucleotide binding169 – 1768ATP By similarity

Sites

Site3701Required for activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4UK16 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: F02F21FCFE79AA5C

FASTA51056,035
        10         20         30         40         50         60 
MKLKPIEVAE ILQKEIANIN CLSELEEVGQ VISVGDGIAK IYGLANVKSG EVVEFKSGVK 

        70         80         90        100        110        120 
GLVLNLENDS VGAVIMGDDN QVQQGDNVKR TKEVLEVPIG KALLGRVVDA LGNPIDGKGD 

       130        140        150        160        170        180 
IASKEYRHIE MKAPGIIERT SVSEPVQTGI KAIDSLIPIG RGQRELIIGD RQTGKTAIAV 

       190        200        210        220        230        240 
DTIINQKQAH SLTNESDKIY CIYVAIGQKR SSVAQIVKKL EDAGAMDYTI VVSATASEAA 

       250        260        270        280        290        300 
ALQFIAPYSA CSMGEYFRDN GMHALIIYDD LSKHAVAYRQ ISLLLRRPPG REAYPGDVFY 

       310        320        330        340        350        360 
LHSRLLERAA KMSEEKGSGS LTALPIIETQ AGDVSAYIPT NVISITDGQI FLESELFYKG 

       370        380        390        400        410        420 
VRPAVNVGIS VSRVGSAAQI KAMKQVAGSV KLELAQFREL ESFSQFGSDL DPATKAQIDH 

       430        440        450        460        470        480 
GKRLVEILKQ AQYHPFPVEE QIVSIYVGTK KYLNDVPLQK VKEFEDKMLT EIRLNKKDIL 

       490        500        510 
ESIKNEQRIT EETEQKLKAF LENFVKEFVK 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY62119.1.
RefSeqYP_247284.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UK16.
SMRQ4UK16. Positions 24-498.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_1268.

Proteomic databases

PRIDEQ4UK16.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY62119; AAY62119; RF_1268.
GeneID3401379.
KEGGrfe:RF_1268.
PATRIC17893432. VBIRicFel64634_1528.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0056.
HOGENOMHOG000130111.
KOK02111.
OMANDEIKDT.
OrthoDBEOG67X1S1.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-1303-MONOMER.

Family and domain databases

Gene3D2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_01346. ATP_synth_alpha_bact.
InterProIPR020003. ATPase_a/bsu_AS.
IPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR15184:SF3. PTHR15184:SF3. 1 hit.
PfamPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00962. atpA. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATPA_RICFE
AccessionPrimary (citable) accession number: Q4UK16
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names