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Q4UK16

- ATPA_RICFE

UniProt

Q4UK16 - ATPA_RICFE

Protein

ATP synthase subunit alpha

Gene

atpA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.UniRule annotation

    Catalytic activityi

    ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei370 – 3701Required for activityUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi169 – 1768ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. proton-transporting ATPase activity, rotational mechanism Source: InterPro
    3. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: InterPro
    2. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    ATP synthesis, Hydrogen ion transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-1303-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP synthase subunit alphaUniRule annotation (EC:3.6.3.14UniRule annotation)
    Alternative name(s):
    ATP synthase F1 sector subunit alphaUniRule annotation
    F-ATPase subunit alphaUniRule annotation
    Gene namesi
    Name:atpAUniRule annotation
    Ordered Locus Names:RF_1268
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell
    2. proton-transporting ATP synthase complex, catalytic core F(1) Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, CF(1), Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 510510ATP synthase subunit alphaPRO_0000238344Add
    BLAST

    Proteomic databases

    PRIDEiQ4UK16.

    Interactioni

    Subunit structurei

    F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_1268.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UK16.
    SMRiQ4UK16. Positions 24-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATPase alpha/beta chains family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0056.
    HOGENOMiHOG000130111.
    KOiK02111.
    OMAiNDEIKDT.
    OrthoDBiEOG67X1S1.

    Family and domain databases

    Gene3Di2.40.30.20. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_01346. ATP_synth_alpha_bact.
    InterProiIPR020003. ATPase_a/bsu_AS.
    IPR023366. ATPase_asu-like.
    IPR005294. ATPase_F1-cplx_asu.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR004100. ATPase_F1_a/bsu_N.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR15184:SF3. PTHR15184:SF3. 1 hit.
    PfamiPF00006. ATP-synt_ab. 1 hit.
    PF00306. ATP-synt_ab_C. 1 hit.
    PF02874. ATP-synt_ab_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47917. SSF47917. 1 hit.
    SSF50615. SSF50615. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00962. atpA. 1 hit.
    PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UK16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLKPIEVAE ILQKEIANIN CLSELEEVGQ VISVGDGIAK IYGLANVKSG    50
    EVVEFKSGVK GLVLNLENDS VGAVIMGDDN QVQQGDNVKR TKEVLEVPIG 100
    KALLGRVVDA LGNPIDGKGD IASKEYRHIE MKAPGIIERT SVSEPVQTGI 150
    KAIDSLIPIG RGQRELIIGD RQTGKTAIAV DTIINQKQAH SLTNESDKIY 200
    CIYVAIGQKR SSVAQIVKKL EDAGAMDYTI VVSATASEAA ALQFIAPYSA 250
    CSMGEYFRDN GMHALIIYDD LSKHAVAYRQ ISLLLRRPPG REAYPGDVFY 300
    LHSRLLERAA KMSEEKGSGS LTALPIIETQ AGDVSAYIPT NVISITDGQI 350
    FLESELFYKG VRPAVNVGIS VSRVGSAAQI KAMKQVAGSV KLELAQFREL 400
    ESFSQFGSDL DPATKAQIDH GKRLVEILKQ AQYHPFPVEE QIVSIYVGTK 450
    KYLNDVPLQK VKEFEDKMLT EIRLNKKDIL ESIKNEQRIT EETEQKLKAF 500
    LENFVKEFVK 510
    Length:510
    Mass (Da):56,035
    Last modified:July 5, 2005 - v1
    Checksum:iF02F21FCFE79AA5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62119.1.
    RefSeqiWP_011271568.1. NC_007109.1.
    YP_247284.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY62119; AAY62119; RF_1268.
    GeneIDi3401379.
    KEGGirfe:RF_1268.
    PATRICi17893432. VBIRicFel64634_1528.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62119.1 .
    RefSeqi WP_011271568.1. NC_007109.1.
    YP_247284.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UK16.
    SMRi Q4UK16. Positions 24-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_1268.

    Proteomic databases

    PRIDEi Q4UK16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY62119 ; AAY62119 ; RF_1268 .
    GeneIDi 3401379.
    KEGGi rfe:RF_1268.
    PATRICi 17893432. VBIRicFel64634_1528.

    Phylogenomic databases

    eggNOGi COG0056.
    HOGENOMi HOG000130111.
    KOi K02111.
    OMAi NDEIKDT.
    OrthoDBi EOG67X1S1.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-1303-MONOMER.

    Family and domain databases

    Gene3Di 2.40.30.20. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_01346. ATP_synth_alpha_bact.
    InterProi IPR020003. ATPase_a/bsu_AS.
    IPR023366. ATPase_asu-like.
    IPR005294. ATPase_F1-cplx_asu.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR004100. ATPase_F1_a/bsu_N.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR15184:SF3. PTHR15184:SF3. 1 hit.
    Pfami PF00006. ATP-synt_ab. 1 hit.
    PF00306. ATP-synt_ab_C. 1 hit.
    PF02874. ATP-synt_ab_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47917. SSF47917. 1 hit.
    SSF50615. SSF50615. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00962. atpA. 1 hit.
    PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiATPA_RICFE
    AccessioniPrimary (citable) accession number: Q4UK16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3