Q4UK16 (ATPA_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP synthase subunit alpha
EC=3.6.3.14

Alternative name(s):
ATP synthase F1 sector subunit alpha
F-ATPase subunit alpha

Gene names

Name:	atpA
Ordered Locus Names:	RF_1268

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia felis

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity. HAMAP-Rule MF_01346
Catalytic activity	ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP-Rule MF_01346
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_01346.
Sequence similarities	Belongs to the ATPase alpha/beta chains family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(1) Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro plasma membrane ATP synthesis coupled proton transport Inferred from electronic annotation. Source: HAMAP
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting ATP synthase complex, catalytic core F(1) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP proton-transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: HAMAP proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 510	510	ATP synthase subunit alpha HAMAP-Rule MF_01346		PRO_0000238344
Regions
	Nucleotide binding	169 – 176	8	ATP By similarity
Sites
	Site	370	1	Required for activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4UK16 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: F02F21FCFE79AA5C	FASTA	510	56,035
	10 20 30 40 50 60 MKLKPIEVAE ILQKEIANIN CLSELEEVGQ VISVGDGIAK IYGLANVKSG EVVEFKSGVK 70 80 90 100 110 120 GLVLNLENDS VGAVIMGDDN QVQQGDNVKR TKEVLEVPIG KALLGRVVDA LGNPIDGKGD 130 140 150 160 170 180 IASKEYRHIE MKAPGIIERT SVSEPVQTGI KAIDSLIPIG RGQRELIIGD RQTGKTAIAV 190 200 210 220 230 240 DTIINQKQAH SLTNESDKIY CIYVAIGQKR SSVAQIVKKL EDAGAMDYTI VVSATASEAA 250 260 270 280 290 300 ALQFIAPYSA CSMGEYFRDN GMHALIIYDD LSKHAVAYRQ ISLLLRRPPG REAYPGDVFY 310 320 330 340 350 360 LHSRLLERAA KMSEEKGSGS LTALPIIETQ AGDVSAYIPT NVISITDGQI FLESELFYKG 370 380 390 400 410 420 VRPAVNVGIS VSRVGSAAQI KAMKQVAGSV KLELAQFREL ESFSQFGSDL DPATKAQIDH 430 440 450 460 470 480 GKRLVEILKQ AQYHPFPVEE QIVSIYVGTK KYLNDVPLQK VKEFEDKMLT EIRLNKKDIL 490 500 510 ESIKNEQRIT EETEQKLKAF LENFVKEFVK

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY62119.1.
RefSeq	YP_247284.1. NC_007109.1.
3D structure databases
ProteinModelPortal	Q4UK16.
SMR	Q4UK16. Positions 24-498.
ModBase	Search...
Protein-protein interaction databases
STRING	315456.RF_1268.
Proteomic databases
PRIDE	Q4UK16.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY62119; AAY62119; RF_1268.
GeneID	3401379.
KEGG	rfe:RF_1268.
PATRIC	17893432. VBIRicFel64634_1528.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0056.
HOGENOM	HOG000130111.
KO	K02111.
OMA	DGIAQIY.
ProtClustDB	PRK09281.
Family and domain databases
Gene3D	2.40.30.20. 1 hit.
HAMAP	MF_01346. ATP_synth_alpha_bact.
InterPro	IPR020003. ATPase_a/bsu_AS. IPR004100. ATPase_a/bsu_N. IPR005294. ATPase_F1-cplx_asu. IPR023366. ATPase_F1/A1-cplx_a_su_N. IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. [Graphical view]
PANTHER	PTHR15184:SF3. PTHR15184:SF3. 1 hit.
Pfam	PF00006. ATP-synt_ab. 1 hit. PF00306. ATP-synt_ab_C. 1 hit. PF02874. ATP-synt_ab_N. 1 hit. [Graphical view]
SUPFAM	SSF47917. ATPase_a/b_C. 1 hit. SSF50615. ATPase_a/b_N. 1 hit.
TIGRFAMs	TIGR00962. atpA. 1 hit.
PROSITE	PS00152. ATPASE_ALPHA_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATPA_RICFE

Accession

Primary (citable) accession number: Q4UK16

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program