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Q4UK16

- ATPA_RICFE

UniProt

Q4UK16 - ATPA_RICFE

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Protein
ATP synthase subunit alpha
Gene
atpA, RF_1268
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei370 – 3701Required for activity By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi169 – 1768ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP
  3. proton-transporting ATPase activity, rotational mechanism Source: InterPro

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1303-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alpha (EC:3.6.3.14)
Alternative name(s):
ATP synthase F1 sector subunit alpha
F-ATPase subunit alpha
Gene namesi
Name:atpA
Ordered Locus Names:RF_1268
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
  2. proton-transporting ATP synthase complex, catalytic core F(1) Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510ATP synthase subunit alphaUniRule annotation
PRO_0000238344Add
BLAST

Proteomic databases

PRIDEiQ4UK16.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.

Protein-protein interaction databases

STRINGi315456.RF_1268.

Structurei

3D structure databases

ProteinModelPortaliQ4UK16.
SMRiQ4UK16. Positions 24-498.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0056.
HOGENOMiHOG000130111.
KOiK02111.
OMAiNDEIKDT.
OrthoDBiEOG67X1S1.

Family and domain databases

Gene3Di2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01346. ATP_synth_alpha_bact.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF3. PTHR15184:SF3. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00962. atpA. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UK16-1 [UniParc]FASTAAdd to Basket

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MKLKPIEVAE ILQKEIANIN CLSELEEVGQ VISVGDGIAK IYGLANVKSG    50
EVVEFKSGVK GLVLNLENDS VGAVIMGDDN QVQQGDNVKR TKEVLEVPIG 100
KALLGRVVDA LGNPIDGKGD IASKEYRHIE MKAPGIIERT SVSEPVQTGI 150
KAIDSLIPIG RGQRELIIGD RQTGKTAIAV DTIINQKQAH SLTNESDKIY 200
CIYVAIGQKR SSVAQIVKKL EDAGAMDYTI VVSATASEAA ALQFIAPYSA 250
CSMGEYFRDN GMHALIIYDD LSKHAVAYRQ ISLLLRRPPG REAYPGDVFY 300
LHSRLLERAA KMSEEKGSGS LTALPIIETQ AGDVSAYIPT NVISITDGQI 350
FLESELFYKG VRPAVNVGIS VSRVGSAAQI KAMKQVAGSV KLELAQFREL 400
ESFSQFGSDL DPATKAQIDH GKRLVEILKQ AQYHPFPVEE QIVSIYVGTK 450
KYLNDVPLQK VKEFEDKMLT EIRLNKKDIL ESIKNEQRIT EETEQKLKAF 500
LENFVKEFVK 510
Length:510
Mass (Da):56,035
Last modified:July 5, 2005 - v1
Checksum:iF02F21FCFE79AA5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62119.1.
RefSeqiWP_011271568.1. NC_007109.1.
YP_247284.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY62119; AAY62119; RF_1268.
GeneIDi3401379.
KEGGirfe:RF_1268.
PATRICi17893432. VBIRicFel64634_1528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62119.1 .
RefSeqi WP_011271568.1. NC_007109.1.
YP_247284.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UK16.
SMRi Q4UK16. Positions 24-498.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_1268.

Proteomic databases

PRIDEi Q4UK16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY62119 ; AAY62119 ; RF_1268 .
GeneIDi 3401379.
KEGGi rfe:RF_1268.
PATRICi 17893432. VBIRicFel64634_1528.

Phylogenomic databases

eggNOGi COG0056.
HOGENOMi HOG000130111.
KOi K02111.
OMAi NDEIKDT.
OrthoDBi EOG67X1S1.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-1303-MONOMER.

Family and domain databases

Gene3Di 2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_01346. ATP_synth_alpha_bact.
InterProi IPR020003. ATPase_a/bsu_AS.
IPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR15184:SF3. PTHR15184:SF3. 1 hit.
Pfami PF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00962. atpA. 1 hit.
PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiATPA_RICFE
AccessioniPrimary (citable) accession number: Q4UK16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2005
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi