Reviewed, UniProtKB/Swiss-Prot Q4UJZ1 (PLD_RICFE)

Names and origin

Protein names

Recommended name:
    Phospholipase D
      Short name=PLD
    EC=3.1.4.4
Alternative name(s):
    Choline phosphatase

Gene names

Name:	pld
Ordered Locus Names:	RF_1297

Organism

Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

42862 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Could be a virulence factor By similarity.
Catalytic activity	A phosphatidylcholine + H2O = choline + a phosphatidate.
Subunit structure	Homodimer By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the phospholipase D family. Contains 1 PLD phosphodiesterase domain.

Ontologies

Keywords
Biological process	Lipid degradation Virulence
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAPE-specific phospholipase D activity Inferred from electronic annotation. Source: EC phospholipase D activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 200	175	Phospholipase D		PRO_0000274783
Regions
	Domain	142 – 169	28	PLD phosphodiesterase
Sites
	Active site	147	1	Potential
	Active site	149	1	Potential
	Active site	154	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4UJZ1-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 23E3ABF9A152C41B	FASTA	200	22,501
	10 20 30 40 50 60 MKRKNNKFIE ISIAFILGVA LGIYGQNPDY FTNLINQKSL ASSAPKIKHY NISELLRSKV 70 80 90 100 110 120 STCFTPPAGC TKFIANQIDR AEESIYMQAY GMSDALITTA LINAQMRGVK VRILLDRSNL 130 140 150 160 170 180 KQKFSKLHEL QRAKIDVGID KVPGIAHNKV IIIDRKKVIT GSFNFTAAAD KRNAENVIII 190 200 EDRELAESYL QNWLNRKASN

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000053 Genomic DNA. Translation: AAY62148.1.
RefSeq	YP_247313.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3400852.
GenomeReviews	Gene locus RF_1297 in contig CP000053_GR.
KEGG	rfe:RF_1297.
NMPDR	fig|315456.3.peg.1297.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4UJZ1.
OMA	Q4UJZ1. PIHHDKV.
Enzyme and pathway databases
BioCyc	RFEL315456:RF_1297-MON.
BRENDA	3.1.4.4. 297363.
Family and domain databases
InterPro	IPR001736. PLipase_D/transphosphatidylase. [Graphical view]
PROSITE	PS50035. PLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PLD_RICFE

Accession

Primary (citable) accession number: Q4UJZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	July 5, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)