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Q4UJV4

- HEM1_RICFE

UniProt

Q4UJV4 - HEM1_RICFE

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Protein

5-aminolevulinate synthase

Gene

hemA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei22 – 221SubstrateBy similarity
Binding sitei133 – 1331SubstrateBy similarity
Binding sitei152 – 1521SubstrateBy similarity
Binding sitei185 – 1851Pyridoxal phosphateBy similarity
Binding sitei213 – 2131Pyridoxal phosphateBy similarity
Binding sitei241 – 2411Pyridoxal phosphateBy similarity
Active sitei244 – 2441By similarity
Binding sitei273 – 2731Pyridoxal phosphateBy similarity
Binding sitei274 – 2741Pyridoxal phosphateBy similarity
Binding sitei359 – 3591SubstrateBy similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1371-MONOMER.
UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:hemA
Ordered Locus Names:RF_1334
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4144145-aminolevulinate synthasePRO_0000280898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei244 – 2441N6-(pyridoxal phosphate)lysineCurated

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1334.

Structurei

3D structure databases

ProteinModelPortaliQ4UJV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0156.
HOGENOMiHOG000221020.
KOiK00643.
OMAiHYLQSIN.
OrthoDBiEOG6Q8HZD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UJV4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYYDTIFSK HIDKIKSEGR YREFKALKRQ ADNFPFAEHA NKQIVMWCIN
60 70 80 90 100
DYLGMSKHAK VMQASIDALL KYGVGSGGTR NIGGNNIAIL ELEKELADLH
110 120 130 140 150
KKQAALVFTS GFVANDTTLA SLAKIMPDIV FFSDELNHAS IIAGVTSSRA
160 170 180 190 200
EKYIYRHLDV KHLEELLQSV DINRPKIIVF ESAYSMDGFF SPIKDIINLA
210 220 230 240 250
KKYNALTFID EVHTVGLYGK HGGGIAELLN CSDQIDIIQG TLAKAYGTIG
260 270 280 290 300
GYITSNHNLV DAIRLTAPGF IFTTSLPPVI STAATHSIRH LKESNEERIK
310 320 330 340 350
HQEVVTKLKN SFENFNIPYL KNESHIVPII IGDPIKAASA SNMLLNKYGI
360 370 380 390 400
YVQHINFPTV PRGTERLRII PTPAHTDKMI NDLSIALVHI FAELDIELSS
410
TKELNEEIRL NLIA
Length:414
Mass (Da):46,180
Last modified:July 5, 2005 - v1
Checksum:i6B7987FD78DEF8AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62185.1.
RefSeqiWP_011271634.1. NC_007109.1.
YP_247350.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY62185; AAY62185; RF_1334.
GeneIDi3400890.
KEGGirfe:RF_1334.
PATRICi17893592. VBIRicFel64634_1606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62185.1 .
RefSeqi WP_011271634.1. NC_007109.1.
YP_247350.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UJV4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_1334.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY62185 ; AAY62185 ; RF_1334 .
GeneIDi 3400890.
KEGGi rfe:RF_1334.
PATRICi 17893592. VBIRicFel64634_1606.

Phylogenomic databases

eggNOGi COG0156.
HOGENOMi HOG000221020.
KOi K00643.
OMAi HYLQSIN.
OrthoDBi EOG6Q8HZD.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .
BioCyci RFEL315456:GKEK-1371-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiHEM1_RICFE
AccessioniPrimary (citable) accession number: Q4UJV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3