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Protein

Trigger factor

Gene

tig

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, Isomerase, Rotamase
Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
TFUniRule annotation
Alternative name(s):
PPIaseUniRule annotation
Gene namesi
Name:tigUniRule annotation
Ordered Locus Names:RF_1336
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm
  • Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002566091 – 445Trigger factorAdd BLAST445

Proteomic databases

PRIDEiQ4UJV2

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1336

Structurei

3D structure databases

ProteinModelPortaliQ4UJV2
SMRiQ4UJV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 247PPIase FKBP-typeUniRule annotationAdd BLAST86

Domaini

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

Sequence similaritiesi

Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DEA Bacteria
COG0544 LUCA
HOGENOMiHOG000218241
KOiK03545
OMAiMAMIEDR
OrthoDBiPOG091H01T7

Family and domain databases

Gene3Di1.10.3120.10, 2 hits
3.30.70.1050, 1 hit
HAMAPiMF_00303 Trigger_factor_Tig, 1 hit
InterProiView protein in InterPro
IPR001179 PPIase_FKBP_dom
IPR005215 Trig_fac
IPR008880 Trigger_fac_C
IPR037041 Trigger_fac_C_sf
IPR008881 Trigger_fac_ribosome-bd_bac
IPR036611 Trigger_fac_ribosome-bd_sf
IPR027304 Trigger_fact/SurA_dom_sf
PANTHERiPTHR30560 PTHR30560, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PF05698 Trigger_C, 1 hit
PF05697 Trigger_N, 1 hit
PIRSFiPIRSF003095 Trigger_factor, 1 hit
SUPFAMiSSF102735 SSF102735, 1 hit
SSF109998 SSF109998, 1 hit
TIGRFAMsiTIGR00115 tig, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q4UJV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGITVLKNEG LDFHARISTP LSEIDDDIQK ELLDLTKKVK IAGFRAGKVP
60 70 80 90 100
VSIVKKKYGT SVRNDIIERR INHSVNHVIK EHNLNIIGRP KIEELQNEPD
110 120 130 140 150
KALEFTVKIE LLPKITIPDL KKISLDRPKL EVNSKDVEEQ LEKLAALTKS
160 170 180 190 200
YTKESKAKIK DGVQVTIDAI GYIKDEAFEG GKLNDFKVVI GSNALIPGFE
210 220 230 240 250
KQLIGSKTGS EVDVNVTFPE NYHAKDLAGK DARFAVQIKS VHTAEPTVID
260 270 280 290 300
EEFAKKFQSN SLEELRTHFA KQIENESEEA INTIMKMNLF DKLEKLLDFD
310 320 330 340 350
VPESLLEQEK NILKSETDKN DQDESLLKDK SPKEITEYYN KLALRRVRIG
360 370 380 390 400
LLLAEYAKSK NLQLEPDDLR KVIMQQARNF PGQENMIFDF YKNNPRAIEG
410 420 430 440
LKGPALEDKA VQYIFNNEIK LKEKKYTKEE LEKYLEAEEQ RITLI
Length:445
Mass (Da):50,878
Last modified:July 5, 2005 - v1
Checksum:i82982B6368A643DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA Translation: AAY62187.1
RefSeqiWP_011271636.1, NC_007109.1

Genome annotation databases

EnsemblBacteriaiAAY62187; AAY62187; RF_1336
KEGGirfe:RF_1336

Similar proteinsi

Entry informationi

Entry nameiTIG_RICFE
AccessioniPrimary (citable) accession number: Q4UJV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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