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Q4UJV2

- TIG_RICFE

UniProt

Q4UJV2 - TIG_RICFE

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Protein
Trigger factor
Gene
tig, RF_1336
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase By similarity.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. protein folding Source: UniProtKB-HAMAP
  4. protein transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1373-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trigger factor (EC:5.2.1.8)
Short name:
TF
Alternative name(s):
PPIase
Gene namesi
Name:tig
Ordered Locus Names:RF_1336
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Cytoplasm
Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Trigger factorUniRule annotation
PRO_0000256609Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_1336.

Structurei

3D structure databases

ProteinModelPortaliQ4UJV2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini162 – 24786PPIase FKBP-type
Add
BLAST

Domaini

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own By similarity.UniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0544.
HOGENOMiHOG000218241.
KOiK03545.
OMAiFKVKVHE.
OrthoDBiEOG63VBX3.

Family and domain databases

Gene3Di1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPiMF_00303. Trigger_factor_Tig.
InterProiIPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003095. Trigger_factor. 1 hit.
SUPFAMiSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsiTIGR00115. tig. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UJV2-1 [UniParc]FASTAAdd to Basket

« Hide

MGITVLKNEG LDFHARISTP LSEIDDDIQK ELLDLTKKVK IAGFRAGKVP    50
VSIVKKKYGT SVRNDIIERR INHSVNHVIK EHNLNIIGRP KIEELQNEPD 100
KALEFTVKIE LLPKITIPDL KKISLDRPKL EVNSKDVEEQ LEKLAALTKS 150
YTKESKAKIK DGVQVTIDAI GYIKDEAFEG GKLNDFKVVI GSNALIPGFE 200
KQLIGSKTGS EVDVNVTFPE NYHAKDLAGK DARFAVQIKS VHTAEPTVID 250
EEFAKKFQSN SLEELRTHFA KQIENESEEA INTIMKMNLF DKLEKLLDFD 300
VPESLLEQEK NILKSETDKN DQDESLLKDK SPKEITEYYN KLALRRVRIG 350
LLLAEYAKSK NLQLEPDDLR KVIMQQARNF PGQENMIFDF YKNNPRAIEG 400
LKGPALEDKA VQYIFNNEIK LKEKKYTKEE LEKYLEAEEQ RITLI 445
Length:445
Mass (Da):50,878
Last modified:July 5, 2005 - v1
Checksum:i82982B6368A643DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62187.1.
RefSeqiYP_247352.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY62187; AAY62187; RF_1336.
GeneIDi3400892.
KEGGirfe:RF_1336.
PATRICi17893596. VBIRicFel64634_1608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62187.1 .
RefSeqi YP_247352.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UJV2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 315456.RF_1336.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY62187 ; AAY62187 ; RF_1336 .
GeneIDi 3400892.
KEGGi rfe:RF_1336.
PATRICi 17893596. VBIRicFel64634_1608.

Phylogenomic databases

eggNOGi COG0544.
HOGENOMi HOG000218241.
KOi K03545.
OMAi FKVKVHE.
OrthoDBi EOG63VBX3.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-1373-MONOMER.

Family and domain databases

Gene3Di 1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPi MF_00303. Trigger_factor_Tig.
InterProi IPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view ]
Pfami PF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF003095. Trigger_factor. 1 hit.
SUPFAMi SSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsi TIGR00115. tig. 1 hit.
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiTIG_RICFE
AccessioniPrimary (citable) accession number: Q4UJV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi