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Q4UJV2

- TIG_RICFE

UniProt

Q4UJV2 - TIG_RICFE

Protein

Trigger factor

Gene

tig

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. protein folding Source: UniProtKB-HAMAP
    4. protein transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone, Isomerase, Rotamase

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-1373-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
    Short name:
    TFUniRule annotation
    Alternative name(s):
    PPIaseUniRule annotation
    Gene namesi
    Name:tigUniRule annotation
    Ordered Locus Names:RF_1336
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cytoplasm
    Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Trigger factorPRO_0000256609Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315456.RF_1336.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UJV2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini162 – 24786PPIase FKBP-typeUniRule annotationAdd
    BLAST

    Domaini

    Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation
    Contains 1 PPIase FKBP-type domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0544.
    HOGENOMiHOG000218241.
    KOiK03545.
    OMAiFKVKVHE.
    OrthoDBiEOG63VBX3.

    Family and domain databases

    Gene3Di1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPiMF_00303. Trigger_factor_Tig.
    InterProiIPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view]
    PfamiPF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003095. Trigger_factor. 1 hit.
    SUPFAMiSSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsiTIGR00115. tig. 1 hit.
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UJV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGITVLKNEG LDFHARISTP LSEIDDDIQK ELLDLTKKVK IAGFRAGKVP    50
    VSIVKKKYGT SVRNDIIERR INHSVNHVIK EHNLNIIGRP KIEELQNEPD 100
    KALEFTVKIE LLPKITIPDL KKISLDRPKL EVNSKDVEEQ LEKLAALTKS 150
    YTKESKAKIK DGVQVTIDAI GYIKDEAFEG GKLNDFKVVI GSNALIPGFE 200
    KQLIGSKTGS EVDVNVTFPE NYHAKDLAGK DARFAVQIKS VHTAEPTVID 250
    EEFAKKFQSN SLEELRTHFA KQIENESEEA INTIMKMNLF DKLEKLLDFD 300
    VPESLLEQEK NILKSETDKN DQDESLLKDK SPKEITEYYN KLALRRVRIG 350
    LLLAEYAKSK NLQLEPDDLR KVIMQQARNF PGQENMIFDF YKNNPRAIEG 400
    LKGPALEDKA VQYIFNNEIK LKEKKYTKEE LEKYLEAEEQ RITLI 445
    Length:445
    Mass (Da):50,878
    Last modified:July 5, 2005 - v1
    Checksum:i82982B6368A643DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62187.1.
    RefSeqiYP_247352.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY62187; AAY62187; RF_1336.
    GeneIDi3400892.
    KEGGirfe:RF_1336.
    PATRICi17893596. VBIRicFel64634_1608.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62187.1 .
    RefSeqi YP_247352.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UJV2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_1336.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY62187 ; AAY62187 ; RF_1336 .
    GeneIDi 3400892.
    KEGGi rfe:RF_1336.
    PATRICi 17893596. VBIRicFel64634_1608.

    Phylogenomic databases

    eggNOGi COG0544.
    HOGENOMi HOG000218241.
    KOi K03545.
    OMAi FKVKVHE.
    OrthoDBi EOG63VBX3.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-1373-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPi MF_00303. Trigger_factor_Tig.
    InterProi IPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view ]
    Pfami PF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003095. Trigger_factor. 1 hit.
    SUPFAMi SSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsi TIGR00115. tig. 1 hit.
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiTIG_RICFE
    AccessioniPrimary (citable) accession number: Q4UJV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3