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Q4UJT2

- TRUA_RICFE

UniProt

Q4UJT2 - TRUA_RICFE

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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521NucleophileUniRule annotation
Binding sitei111 – 1111SubstrateUniRule annotation

GO - Molecular functioni

  1. pseudouridine synthase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: InterPro

GO - Biological processi

  1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1393-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:RF_1356
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245tRNA pseudouridine synthase APRO_0000278056Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_1356.

Structurei

3D structure databases

ProteinModelPortaliQ4UJT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0101.
HOGENOMiHOG000248672.
KOiK06173.
OMAiYLTKVEY.
OrthoDBiEOG6Z9B4R.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UJT2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYRYKITIEY LGTNLAGWQR QAGVISVQQI LEEAIYKFSG EQVILFGSGR
60 70 80 90 100
TDAGVHAIGQ VAHFDLSKHL EPHKIITAIN YFARPYAVGV WNCELASNNF
110 120 130 140 150
HARFSATSRH YIYRIINRPY PSVIDLNRAW WISSPLDVLT MQKAAAYLLG
160 170 180 190 200
KHDFTSFRAS SCQSKSPIKT LTELNIIKED EEIKLYLSAP SFLHHMVRNI
210 220 230 240
VGSLVLVGKN VWQAEQIKDV LEAKDRKAAG PTAPASGLYF VKTEY
Length:245
Mass (Da):27,679
Last modified:July 5, 2005 - v1
Checksum:i77D64C06DDDB7939
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY62207.1.
RefSeqiYP_247372.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY62207; AAY62207; RF_1356.
GeneIDi3400912.
KEGGirfe:RF_1356.
PATRICi17893648. VBIRicFel64634_1634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY62207.1 .
RefSeqi YP_247372.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UJT2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_1356.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY62207 ; AAY62207 ; RF_1356 .
GeneIDi 3400912.
KEGGi rfe:RF_1356.
PATRICi 17893648. VBIRicFel64634_1634.

Phylogenomic databases

eggNOGi COG0101.
HOGENOMi HOG000248672.
KOi K06173.
OMAi YLTKVEY.
OrthoDBi EOG6Z9B4R.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-1393-MONOMER.

Family and domain databases

Gene3Di 3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPi MF_00171. TruA.
InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view ]
PANTHERi PTHR11142. PTHR11142. 1 hit.
Pfami PF01416. PseudoU_synth_1. 2 hits.
[Graphical view ]
PIRSFi PIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMi SSF55120. SSF55120. 1 hit.
TIGRFAMsi TIGR00071. hisT_truA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiTRUA_RICFE
AccessioniPrimary (citable) accession number: Q4UJT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3