SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4UJN0

- LPXB_RICFE

UniProt

Q4UJN0 - LPXB_RICFE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Lipid-A-disaccharide synthase

Gene
lpxB, RF_0519
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-533-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:RF_0519
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Lipid-A-disaccharide synthaseUniRule annotationPRO_0000255218Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0519.

Structurei

3D structure databases

ProteinModelPortaliQ4UJN0.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UJN0-1 [UniParc]FASTAAdd to Basket

« Hide

MTKIYFIAGE TSGDFIGGRI IQHLKDNIEI KCMGVGGKYM EEAGSFKSLF    50
SITSINLMGF VEILPHIFKL KKLIDKTVED ITNSRADLLI TIDSPGFTYR 100
VAKRVRKLLP KLKMIHIVAP SVWAYKEDRA VKYAQIYDCL FALLPFEPPY 150
FTRLGLDCRY IGHPIMEQEF YSDKVALRKE FKIDENERVL CVTLGSRKGE 200
ILRHLPVFVS SIEEIFKSCN NLKVIFTLAN PAHEAIIKPF LEDVKFNYLF 250
SSERLKTYAV ADAALAKSGT NTLEIAASGT PMIVAYKVNL ISFFIIRLLI 300
KIKYVTLINI IAGSEIIPEF IQFNCRASLI SNKLQELLFN SKKAYEQVIE 350
SQKILQKLGF ESNRSPSYIA AEIIKQEFLK PKIKLLKEKD 390
Length:390
Mass (Da):44,462
Last modified:July 5, 2005 - v1
Checksum:iDEF77F27C3025238
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61370.1.
RefSeqiYP_246535.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61370; AAY61370; RF_0519.
GeneIDi3401181.
KEGGirfe:RF_0519.
PATRICi17891560. VBIRicFel64634_0613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61370.1 .
RefSeqi YP_246535.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UJN0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0519.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61370 ; AAY61370 ; RF_0519 .
GeneIDi 3401181.
KEGGi rfe:RF_0519.
PATRICi 17891560. VBIRicFel64634_0613.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci RFEL315456:GKEK-533-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiLPXB_RICFE
AccessioniPrimary (citable) accession number: Q4UJN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi