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Q4UJM1

- SDHA_RICFE

UniProt

Q4UJM1 - SDHA_RICFE

Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    FAD.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei225 – 2251FADBy similarity
    Binding sitei246 – 2461SubstrateBy similarity
    Binding sitei258 – 2581SubstrateBy similarity
    Active sitei290 – 2901Proton acceptorBy similarity
    Binding sitei357 – 3571SubstrateBy similarity
    Binding sitei391 – 3911FADBy similarity
    Binding sitei402 – 4021SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 236FADBy similarity
    Nucleotide bindingi41 – 5616FADBy similarityAdd
    BLAST
    Nucleotide bindingi407 – 4082FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-3983-MONOMER.
    RFEL315456:GKEK-1193-MONOMER.
    UniPathwayiUPA00223; UER01005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1)
    Gene namesi
    Name:sdhA
    Ordered Locus Names:RF_1159
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cell inner membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 596596Succinate dehydrogenase flavoprotein subunitPRO_0000280977Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei49 – 491Tele-8alpha-FAD histidineBy similarity

    Interactioni

    Subunit structurei

    Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

    Protein-protein interaction databases

    STRINGi315456.RF_1159.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UJM1.
    SMRiQ4UJM1. Positions 5-596.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1053.
    HOGENOMiHOG000160475.
    KOiK00239.
    OMAiSYRPVHV.
    OrthoDBiEOG6M3PC4.

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UJM1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKAYNIIHH KFDVVVVGAG GAGLRSAFGM AKEGLNTACI TKLFPTRSHT    50
    VAAQGGISAA LGNMGEDDWR WHMYDTVKGS DWLGDQDAIE YMCKNAPDAI 100
    LELEHYGVPF SRTEEGKIYQ RPFGGMTTEY GKGKAAQRTC AAADRTGHAI 150
    LHTLYQQSLK HKVQFFVEYF AIDLLMEDGE CRGVVVWNLD DGTLHCFRAH 200
    NVVLATGGYG RAYFSATSAH TCTGDGGGMA IRAGLPLQDM EFVQFHPTGI 250
    YSAGCLITEG ARGEGGYLVN ANGERFMERY APAAKDLASR DVVSRAMTIE 300
    IREGRGVGEH KDHVFLHLNH LSPEILHSRL PGISETAKIF AGVDVTKEPI 350
    PVLPTVHYNM GGIPTNYHGQ VIIKDGTNHN SVVKGLMAIG EAACVSVHGA 400
    NRLGSNSLLD LVVFGRSSAL KAAELISPAS PHKPIKEASL EKIINRFDKV 450
    RHANGNILVA DLRLKMQRTM QSHASVFRTQ EVLDEGAGMI SEIRNGYKDI 500
    KINDKSLIWN SDLVEALELD NLLDQALVTV YSAAARKESR GAHAREDYPD 550
    RNDGDWMKHT LSSIDEAGKI VIDYKPVTLT TLTDEISAIP PAKRVY 596
    Length:596
    Mass (Da):65,130
    Last modified:July 5, 2005 - v1
    Checksum:i9AF860F6EEFEB3E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62010.1.
    RefSeqiWP_011271467.1. NC_007109.1.
    YP_247175.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY62010; AAY62010; RF_1159.
    GeneIDi3401457.
    KEGGirfe:RF_1159.
    PATRICi17893166. VBIRicFel64634_1396.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY62010.1 .
    RefSeqi WP_011271467.1. NC_007109.1.
    YP_247175.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UJM1.
    SMRi Q4UJM1. Positions 5-596.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_1159.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY62010 ; AAY62010 ; RF_1159 .
    GeneIDi 3401457.
    KEGGi rfe:RF_1159.
    PATRICi 17893166. VBIRicFel64634_1396.

    Phylogenomic databases

    eggNOGi COG1053.
    HOGENOMi HOG000160475.
    KOi K00239.
    OMAi SYRPVHV.
    OrthoDBi EOG6M3PC4.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01005 .
    BioCyci RETL1328306-WGS:GSTH-3983-MONOMER.
    RFEL315456:GKEK-1193-MONOMER.

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiSDHA_RICFE
    AccessioniPrimary (citable) accession number: Q4UJM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3