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Q4UJM1

- SDHA_RICFE

UniProt

Q4UJM1 - SDHA_RICFE

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Protein
Succinate dehydrogenase flavoprotein subunit
Gene
sdhA, RF_1159
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FAD.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei225 – 2251FAD By similarity
Binding sitei246 – 2461Substrate By similarity
Binding sitei258 – 2581Substrate By similarity
Active sitei290 – 2901Proton acceptor By similarity
Binding sitei357 – 3571Substrate By similarity
Binding sitei391 – 3911FAD By similarity
Binding sitei402 – 4021Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 236FAD By similarity
Nucleotide bindingi41 – 5616FAD By similarity
Add
BLAST
Nucleotide bindingi407 – 4082FAD By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3983-MONOMER.
RFEL315456:GKEK-1193-MONOMER.
UniPathwayiUPA00223; UER01005.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1)
Gene namesi
Name:sdhA
Ordered Locus Names:RF_1159
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Succinate dehydrogenase flavoprotein subunit
PRO_0000280977Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491Tele-8alpha-FAD histidine By similarity

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Protein-protein interaction databases

STRINGi315456.RF_1159.

Structurei

3D structure databases

ProteinModelPortaliQ4UJM1.
SMRiQ4UJM1. Positions 5-596.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1053.
HOGENOMiHOG000160475.
KOiK00239.
OMAiSYRPVHV.
OrthoDBiEOG6M3PC4.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UJM1-1 [UniParc]FASTAAdd to Basket

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MTKAYNIIHH KFDVVVVGAG GAGLRSAFGM AKEGLNTACI TKLFPTRSHT    50
VAAQGGISAA LGNMGEDDWR WHMYDTVKGS DWLGDQDAIE YMCKNAPDAI 100
LELEHYGVPF SRTEEGKIYQ RPFGGMTTEY GKGKAAQRTC AAADRTGHAI 150
LHTLYQQSLK HKVQFFVEYF AIDLLMEDGE CRGVVVWNLD DGTLHCFRAH 200
NVVLATGGYG RAYFSATSAH TCTGDGGGMA IRAGLPLQDM EFVQFHPTGI 250
YSAGCLITEG ARGEGGYLVN ANGERFMERY APAAKDLASR DVVSRAMTIE 300
IREGRGVGEH KDHVFLHLNH LSPEILHSRL PGISETAKIF AGVDVTKEPI 350
PVLPTVHYNM GGIPTNYHGQ VIIKDGTNHN SVVKGLMAIG EAACVSVHGA 400
NRLGSNSLLD LVVFGRSSAL KAAELISPAS PHKPIKEASL EKIINRFDKV 450
RHANGNILVA DLRLKMQRTM QSHASVFRTQ EVLDEGAGMI SEIRNGYKDI 500
KINDKSLIWN SDLVEALELD NLLDQALVTV YSAAARKESR GAHAREDYPD 550
RNDGDWMKHT LSSIDEAGKI VIDYKPVTLT TLTDEISAIP PAKRVY 596
Length:596
Mass (Da):65,130
Last modified:July 5, 2005 - v1
Checksum:i9AF860F6EEFEB3E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62010.1.
RefSeqiWP_011271467.1. NC_007109.1.
YP_247175.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY62010; AAY62010; RF_1159.
GeneIDi3401457.
KEGGirfe:RF_1159.
PATRICi17893166. VBIRicFel64634_1396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY62010.1 .
RefSeqi WP_011271467.1. NC_007109.1.
YP_247175.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UJM1.
SMRi Q4UJM1. Positions 5-596.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_1159.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY62010 ; AAY62010 ; RF_1159 .
GeneIDi 3401457.
KEGGi rfe:RF_1159.
PATRICi 17893166. VBIRicFel64634_1396.

Phylogenomic databases

eggNOGi COG1053.
HOGENOMi HOG000160475.
KOi K00239.
OMAi SYRPVHV.
OrthoDBi EOG6M3PC4.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01005 .
BioCyci RETL1328306-WGS:GSTH-3983-MONOMER.
RFEL315456:GKEK-1193-MONOMER.

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiSDHA_RICFE
AccessioniPrimary (citable) accession number: Q4UJM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi