Reviewed, UniProtKB/Swiss-Prot Q4UJ75 (A20A4_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 20A4

Gene names

Name:

ANKRD20A4

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	823 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 5 ANK repeats.

Ontologies

Keywords
Domain	ANK repeat Coiled coil Repeat
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 823	823	Ankyrin repeat domain-containing protein 20A4		PRO_0000240835
Regions
	Repeat	66 – 95	30	ANK 1
	Repeat	99 – 128	30	ANK 2
	Repeat	132 – 161	30	ANK 3
	Repeat	165 – 194	30	ANK 4
	Repeat	198 – 227	30	ANK 5
	Coiled coil	431 – 480	50	Potential
	Coiled coil	565 – 724	160	Potential
	Coiled coil	776 – 806	31	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4UJ75-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 597B760D5733208A	FASTA	823	94,149
	10 20 30 40 50 60 MKLFGFGSRR GQTAQGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE RCLARRSGEL 70 80 90 100 110 120 DALDKQHRTA LHLACASGHV QVVTLLVNRK CQIDVCDKEN RTPLIQAVHC QEEACAVILL 130 140 150 160 170 180 EHGANPNLKD IYGNTALHYA VYSESTSLAE KLLSHGAHIE ALDKDNNTPL LFAIICKKEK 190 200 210 220 230 240 MVEFLLKKKA SSHAVDRLRR SALMLAVYYD SPGIVNILLK QNIDVFAQDM CGRDAEDYAI 250 260 270 280 290 300 SHHLTKIQQQ ILEHKKKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLNVATKQC 310 320 330 340 350 360 VPEKVSEPLP GSSHEKGNRI VNGQGEGPPA KHPSLKPSTE VEDPAVKGAV QRKNVQTLRA 370 380 390 400 410 420 EQALPVASEE EQQRHERSEK KQPQVKEGNN TNKSEKIQLS ENICDSTSSA AAGRLTQQRK 430 440 450 460 470 480 IGKTYPQQFP KKLKEEHDRC TLKQENEEKT NVNMLYKKNR EELERKEKQY KKEVEAKQLE 490 500 510 520 530 540 PTVQSLEMKS KTARNTPNWD FHNHEEMKGL MDENCILKAD IAILRQEICT MKNDNLEKEN 550 560 570 580 590 600 KYLKDIKIVK ETNAALEKYI KLNEEMITET AFRYQQELND LKAENTRLNA ELLKEKESKK 610 620 630 640 650 660 RLEADIESYQ SRLAAAISKH SESVKTERNL KLALERTQDV SVQVEMSSAI SKVKDENEFL 670 680 690 700 710 720 TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNNLS QTQQQTQEMK EMYQNAEAKV 730 740 750 760 770 780 NNSTGKWNCV EERICHLQRE NAWLVQQLDD VHQKEDHKEI VTNIQRGFIE SGKKDFVLEE 790 800 810 820 KSKKLMNECD HLKESLFQYE REKTEVVVSI KEDKYFQTSR KKI

References

[1]

"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR769776 Genomic DNA. Translation: CAI95383.1.
IPI	IPI00552956.
RefSeq	NP_001092275.1.
UniGene	Hs.645502
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENST00000357336; ENSP00000349891; ENSG00000172014; Homo sapiens. [Genome view]
GeneID	728747.
KEGG	hsa:728747.
UCSC	uc004afn.1. human.
Organism-specific databases
CTD	728747.
GeneCards	GC09P068672.
HGNC	HGNC:31982. ANKRD20A4.
PharmGKB	PA142672619.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q4UJ75.
HOVERGEN	Q4UJ75.
OrthoDB	EOG9N8TSX
Gene expression databases
Bgee	Q4UJ75.
CleanEx	HS_ANKRD20A4.
Genevestigator	Q4UJ75.
GermOnline	ENSG00000172014. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 5 hits. [Graphical view]
SMART	SM00248. ANK. 6 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	128184.

Entry information

Entry name

A20A4_HUMAN

Accession

Primary (citable) accession number: Q4UJ75

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	July 5, 2005
Last modified:	November 24, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.