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Q4UJ69

- COX1_THEAN

UniProt

Q4UJ69 - COX1_THEAN

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Protein

Cytochrome c oxidase subunit 1

Gene

MT-CO1

Organism
Theileria annulata
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Iron (heme A axial ligand)By similarity
Metal bindingi246 – 2461Copper BBy similarity
Metal bindingi250 – 2501Copper BBy similarity
Metal bindingi382 – 3821Iron (heme A3 axial ligand)By similarity
Metal bindingi384 – 3841Iron (heme A axial ligand)By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
ORF Names:Tap370b08.q2ca38.01
Encoded oniMitochondrion
OrganismiTheileria annulata
Taxonomic identifieri5874 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaPiroplasmidaTheileriidaeTheileria
ProteomesiUP000001950: Mitochondrion

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Cytochrome c oxidase subunit 1PRO_0000233106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki246 ↔ 2501'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Protein-protein interaction databases

STRINGi5874.Q4UJ69.

Structurei

3D structure databases

ProteinModelPortaliQ4UJ69.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Transmembranei64 – 8421HelicalSequence AnalysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence AnalysisAdd
BLAST
Transmembranei278 – 29821HelicalSequence AnalysisAdd
BLAST
Transmembranei309 – 32921HelicalSequence AnalysisAdd
BLAST
Transmembranei343 – 36321HelicalSequence AnalysisAdd
BLAST
Transmembranei382 – 40221HelicalSequence AnalysisAdd
BLAST
Transmembranei416 – 43621HelicalSequence AnalysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
InParanoidiQ4UJ69.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UJ69-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVFEFVLSLF NSVSGNHKII GISYLWLAYW FGMIGFYMSV LIRTELGMSG
60 70 80 90 100
LKIITMDTLE IYNLLFTLHG LIMVFFNIMT GLFGGIGNYL YPVLLGSCDV
110 120 130 140 150
VYPRVNLYSL LLQPIGFVLV VSSVYLEIGS GTGWTLYPPL STSLSNIGID
160 170 180 190 200
LIIFGLLAAG IASTLSSINF ITTFASIKTI GFVIDRISPA AWSIVLTSFL
210 220 230 240 250
LLLSLPVVTA VFLMVFFDRN HSTMFFESSN SGDPILYQHL FWFFGHPEVY
260 270 280 290 300
IMILPGFGII SLLLSTYTTK EMFGNQTMIL AMGSIALLGC LVWGHHMYTS
310 320 330 340 350
GLEADTRGYF TTVTILIALP TGNKIFNWVT TLQCVESIKS LGLILFAVLF
360 370 380 390 400
IVNFVIGGTT GVVLGNAGLD VVLHDTVYVV GHFHFVLSIG AIISLICFIV
410 420 430 440 450
YIQRMLFGII LSNRLLSLMA PIFMIAVLFT FLPMHFTGFS PLPRRIPDYP
460 470 480
DEMWGWNFIC TLGATMMLVL KLTVLFIISL
Length:480
Mass (Da):53,241
Last modified:May 2, 2006 - v2
Checksum:iAE9889CE4FEB58AE
GO

Sequence cautioni

The sequence CAI72674.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR940346 Genomic DNA. Translation: CAI72674.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR940346 Genomic DNA. Translation: CAI72674.1 . Different initiation.

3D structure databases

ProteinModelPortali Q4UJ69.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5874.Q4UJ69.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
InParanoidi Q4UJ69.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ankara.

Entry informationi

Entry nameiCOX1_THEAN
AccessioniPrimary (citable) accession number: Q4UJ69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: October 29, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3