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Q4UJ69 (COX1_THEAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
ORF Names:Tap370b08.q2ca38.01
Encoded onMitochondrion
OrganismTheileria annulata [Reference proteome]
Taxonomic identifier5874 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaPiroplasmidaTheileriidaeTheileria

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence caution

The sequence CAI72674.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480Cytochrome c oxidase subunit 1
PRO_0000233106

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane64 – 8421Helical; Potential
Transmembrane109 – 12921Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane240 – 26021Helical; Potential
Transmembrane278 – 29821Helical; Potential
Transmembrane309 – 32921Helical; Potential
Transmembrane343 – 36321Helical; Potential
Transmembrane382 – 40221Helical; Potential
Transmembrane416 – 43621Helical; Potential
Transmembrane458 – 47821Helical; Potential

Sites

Metal binding691Iron (heme A axial ligand) By similarity
Metal binding2461Copper B By similarity
Metal binding2501Copper B By similarity
Metal binding3821Iron (heme A3 axial ligand) By similarity
Metal binding3841Iron (heme A axial ligand) By similarity

Amino acid modifications

Cross-link246 ↔ 2501'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4UJ69 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: AE9889CE4FEB58AE

FASTA48053,241
        10         20         30         40         50         60 
MVFEFVLSLF NSVSGNHKII GISYLWLAYW FGMIGFYMSV LIRTELGMSG LKIITMDTLE 

        70         80         90        100        110        120 
IYNLLFTLHG LIMVFFNIMT GLFGGIGNYL YPVLLGSCDV VYPRVNLYSL LLQPIGFVLV 

       130        140        150        160        170        180 
VSSVYLEIGS GTGWTLYPPL STSLSNIGID LIIFGLLAAG IASTLSSINF ITTFASIKTI 

       190        200        210        220        230        240 
GFVIDRISPA AWSIVLTSFL LLLSLPVVTA VFLMVFFDRN HSTMFFESSN SGDPILYQHL 

       250        260        270        280        290        300 
FWFFGHPEVY IMILPGFGII SLLLSTYTTK EMFGNQTMIL AMGSIALLGC LVWGHHMYTS 

       310        320        330        340        350        360 
GLEADTRGYF TTVTILIALP TGNKIFNWVT TLQCVESIKS LGLILFAVLF IVNFVIGGTT 

       370        380        390        400        410        420 
GVVLGNAGLD VVLHDTVYVV GHFHFVLSIG AIISLICFIV YIQRMLFGII LSNRLLSLMA 

       430        440        450        460        470        480 
PIFMIAVLFT FLPMHFTGFS PLPRRIPDYP DEMWGWNFIC TLGATMMLVL KLTVLFIISL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR940346 Genomic DNA. Translation: CAI72674.1. Different initiation.

3D structure databases

ProteinModelPortalQ4UJ69.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5874.Q4UJ69.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0843.
HOGENOMHOG000085274.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_THEAN
AccessionPrimary (citable) accession number: Q4UJ69
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways