Cytochrome c oxidase subunit 1 - Theileria annulata

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Q4UJ69 (COX1_THEAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 49. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 1
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide I

Gene names

Name:	MT-CO1
Synonyms:	COI, COXI, MTCO1
ORF Names:	Tap370b08.q2ca38.01

Encoded on

Mitochondrion

Organism

Theileria annulata [Reference proteome]

Taxonomic identifier

5874 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Piroplasmida › Theileriidae › Theileria

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.
Catalytic activity	4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O.
Pathway	Energy metabolism; oxidative phosphorylation.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the heme-copper respiratory oxidase family.
Sequence caution	The sequence CAI72674.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW oxidative phosphorylation Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 480

480

Cytochrome c oxidase subunit 1

PRO_0000233106

Regions

Transmembrane

22 – 42

Helical; Potential

Transmembrane

64 – 84

Helical; Potential

Transmembrane

109 – 129

Helical; Potential

Transmembrane

151 – 171

Helical; Potential

Transmembrane

194 – 214

Helical; Potential

Transmembrane

240 – 260

Helical; Potential

Transmembrane

278 – 298

Helical; Potential

Transmembrane

309 – 329

Helical; Potential

Transmembrane

343 – 363

Helical; Potential

Transmembrane

382 – 402

Helical; Potential

Transmembrane

416 – 436

Helical; Potential

Transmembrane

458 – 478

Helical; Potential

Sites

Metal binding

Iron (heme A axial ligand) By similarity

Metal binding

246

Copper B By similarity

Metal binding

250

Copper B By similarity

Metal binding

382

Iron (heme A3 axial ligand) By similarity

Metal binding

384

Iron (heme A axial ligand) By similarity

Amino acid modifications

Cross-link

246 ↔ 250

1'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q4UJ69 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: AE9889CE4FEB58AE
Show »

FASTA

480

53,241

        10         20         30         40         50         60 
MVFEFVLSLF NSVSGNHKII GISYLWLAYW FGMIGFYMSV LIRTELGMSG LKIITMDTLE 

        70         80         90        100        110        120 
IYNLLFTLHG LIMVFFNIMT GLFGGIGNYL YPVLLGSCDV VYPRVNLYSL LLQPIGFVLV 

       130        140        150        160        170        180 
VSSVYLEIGS GTGWTLYPPL STSLSNIGID LIIFGLLAAG IASTLSSINF ITTFASIKTI 

       190        200        210        220        230        240 
GFVIDRISPA AWSIVLTSFL LLLSLPVVTA VFLMVFFDRN HSTMFFESSN SGDPILYQHL 

       250        260        270        280        290        300 
FWFFGHPEVY IMILPGFGII SLLLSTYTTK EMFGNQTMIL AMGSIALLGC LVWGHHMYTS 

       310        320        330        340        350        360 
GLEADTRGYF TTVTILIALP TGNKIFNWVT TLQCVESIKS LGLILFAVLF IVNFVIGGTT 

       370        380        390        400        410        420 
GVVLGNAGLD VVLHDTVYVV GHFHFVLSIG AIISLICFIV YIQRMLFGII LSNRLLSLMA 

       430        440        450        460        470        480 
PIFMIAVLFT FLPMHFTGFS PLPRRIPDYP DEMWGWNFIC TLGATMMLVL KLTVLFIISL

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References

[1]

"Genome of the host-cell transforming parasite Theileria annulata compared with T. parva."
Pain A., Renauld H., Berriman M., Murphy L., Yeats C.A., Weir W., Kerhornou A., Aslett M., Bishop R., Bouchier C., Cochet M., Coulson R.M.R., Cronin A., de Villiers E.P., Fraser A., Fosker N., Gardner M., Goble A.

Hall N.
Science 309:131-133(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ankara.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR940346 Genomic DNA. Translation: CAI72674.1. Different initiation.
3D structure databases
ProteinModelPortal	Q4UJ69.
ModBase	Search...
Protein-protein interaction databases
STRING	5874.Q4UJ69.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG0843.
HOGENOM	HOG000085274.
Enzyme and pathway databases
UniPathway	UPA00705.
Family and domain databases
Gene3D	1.20.210.10. 1 hit.
InterPro	IPR000883. Cyt_c_Oxase_su1. IPR023615. Cyt_c_Oxase_su1_BS. IPR023616. Cyt_c_Oxase_su1_dom. [Graphical view]
PANTHER	PTHR10422. PTHR10422. 1 hit.
Pfam	PF00115. COX1. 1 hit. [Graphical view]
PRINTS	PR01165. CYCOXIDASEI.
SUPFAM	SSF81442. COX1. 1 hit.
PROSITE	PS50855. COX1. 1 hit. PS00077. COX1_CUB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX1_THEAN

Accession

Primary (citable) accession number: Q4UJ69

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	May 2, 2006
Last modified:	May 1, 2013
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents