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Q4U3Y2 (HXK1_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hexokinase-1

EC=2.7.1.1
Alternative name(s):
Hexokinase I
Gene names
Name:hxkA
ORF Names:AFUA_7G04040
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaemitosporic TrichocomaceaeAspergillus

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathway

Carbohydrate metabolism; hexose metabolism.

Sequence similarities

Belongs to the hexokinase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

hexokinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Hexokinase-1
PRO_0000197605

Regions

Region159 – 18527Glucose-binding Potential

Sites

Binding site1101ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4U3Y2 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 3B4C9CDA5770DC92

FASTA54960,665
        10         20         30         40         50         60 
MTAPLVKVLH RMQELFSNIV AALEAMIVFP SLFRDPSRKR RKTFHGAYWR RRTLDNFAEE 

        70         80         90        100        110        120 
VDRLFTSPLS LRNMIIMSEK IREQFKSCLQ SSPVCMLPSY NHALPSGTEK GTYLALDVGG 

       130        140        150        160        170        180 
STFRVALIEL GGAGAMKILQ ESSSPIDNDV KLLEGTLFFD WMAEKIESML SAVGADYGRE 

       190        200        210        220        230        240 
AVPLSMGLSW SFPIEQTSIS SGLVIHMGKG FLCSNGTLGQ ELGDLIVQSC RRRSLNVRVD 

       250        260        270        280        290        300 
AIVNDSSAAL LSRAYVDPKT RMSLILGTGT NVAVHFPVRE IGLTKFGTRP PGWFDYAKHV 

       310        320        330        340        350        360 
IINSELSMFG GGILPMTRWD DILNQTHLRP DYQPLEYMVT GRYLGEIVRL IITEAVETAN 

       370        380        390        400        410        420 
LFRGELPHSM RDPYSFDTSI VAFLEADTSP SLVPSAALLQ KEHTFPVSPS VEDLRFLRRI 

       430        440        450        460        470        480 
CQIVSKRAAG YLATAIHSMW CLRNDAEFSD PTESKASSVK DTQEITIVES EEDSRSLSIA 

       490        500        510        520        530        540 
CDGSVINKYP GFRDRCQGYL NQLTQQTNSS QGPLDPATSP YIRLELAPES AILGAAVAVA 


VAVEDQKSG 

« Hide

References

« Hide 'large scale' references
[1]"Hexokinase I from Aspergillus fumigatus YJ407."
Ouyang H., Zhou H., Jin C.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: YJ-407.
[2]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ013853 mRNA. Translation: AAY42969.1.
AAHF01000009 Genomic DNA. Translation: EAL87066.1.
RefSeqXP_749104.1. XM_744011.1.

3D structure databases

ProteinModelPortalQ4U3Y2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4U3Y2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00009350; CADAFUAP00009350; CADAFUAG00009350.
GeneID3506468.
GenomeReviewsGene locus hxkA in contig CM000175_GR.
KEGGafm:AFUA_7G04040.

Phylogenomic databases

eggNOGfuNOG07300.
GeneTreeEFGT00050000004723.
HOGENOMHBG325467.
OMACMLPSYN.
OrthoDBEOG4K0TX4.

Family and domain databases

InterProIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
KOK00844.
PANTHERPTHR19443. Hexokinase. 1 hit.
PfamPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSPR00475. HEXOKINASE.
PROSITEPS00378. HEXOKINASES. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXK1_ASPFU
AccessionPrimary (citable) accession number: Q4U3Y2
Secondary accession number(s): Q4WG75
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2005
Last modified: December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families