Q4U3Y2 (HXK1_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hexokinase-1
EC=2.7.1.1

Alternative name(s):
Hexokinase I

Gene names

Name:	hxkA
ORF Names:	AFUA_7G04040

Organism

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

Taxonomic identifier

330879 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + D-hexose = ADP + D-hexose 6-phosphate.
Pathway	Carbohydrate metabolism; hexose metabolism.
Sequence similarities	Belongs to the hexokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 549	549	Hexokinase-1		PRO_0000197605
Regions
	Region	159 – 185	27	Glucose-binding Potential
Sites
	Binding site	110	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4U3Y2 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 3B4C9CDA5770DC92	FASTA	549	60,665
	10 20 30 40 50 60 MTAPLVKVLH RMQELFSNIV AALEAMIVFP SLFRDPSRKR RKTFHGAYWR RRTLDNFAEE 70 80 90 100 110 120 VDRLFTSPLS LRNMIIMSEK IREQFKSCLQ SSPVCMLPSY NHALPSGTEK GTYLALDVGG 130 140 150 160 170 180 STFRVALIEL GGAGAMKILQ ESSSPIDNDV KLLEGTLFFD WMAEKIESML SAVGADYGRE 190 200 210 220 230 240 AVPLSMGLSW SFPIEQTSIS SGLVIHMGKG FLCSNGTLGQ ELGDLIVQSC RRRSLNVRVD 250 260 270 280 290 300 AIVNDSSAAL LSRAYVDPKT RMSLILGTGT NVAVHFPVRE IGLTKFGTRP PGWFDYAKHV 310 320 330 340 350 360 IINSELSMFG GGILPMTRWD DILNQTHLRP DYQPLEYMVT GRYLGEIVRL IITEAVETAN 370 380 390 400 410 420 LFRGELPHSM RDPYSFDTSI VAFLEADTSP SLVPSAALLQ KEHTFPVSPS VEDLRFLRRI 430 440 450 460 470 480 CQIVSKRAAG YLATAIHSMW CLRNDAEFSD PTESKASSVK DTQEITIVES EEDSRSLSIA 490 500 510 520 530 540 CDGSVINKYP GFRDRCQGYL NQLTQQTNSS QGPLDPATSP YIRLELAPES AILGAAVAVA VAVEDQKSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Hexokinase I from Aspergillus fumigatus YJ407." Ouyang H., Zhou H., Jin C. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: YJ-407.
[2]	"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ013853 mRNA. Translation: AAY42969.1. AAHF01000009 Genomic DNA. Translation: EAL87066.1.
RefSeq	XP_749104.1. XM_744011.1.
3D structure databases
ProteinModelPortal	Q4U3Y2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4U3Y2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADAFUAT00009350; CADAFUAP00009350; CADAFUAG00009350.
GeneID	3506468.
GenomeReviews	Gene locus hxkA in contig CM000175_GR.
KEGG	afm:AFUA_7G04040.
Phylogenomic databases
eggNOG	fuNOG07300.
GeneTree	EFGT00050000004723.
HOGENOM	HBG325467.
OMA	CMLPSYN.
OrthoDB	EOG4K0TX4.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR022672. Hexokinase_N. [Graphical view]
KO	K00844.
PANTHER	PTHR19443. Hexokinase. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. PF03727. Hexokinase_2. 2 hits. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXK1_ASPFU

Accession

Primary (citable) accession number: Q4U3Y2
Secondary accession number(s): Q4WG75

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	July 5, 2005
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program