ID   MPG1_ASPFU              Reviewed;         364 AA.
AC   Q4U3E8; Q4WQ43;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase;
DE            EC=2.7.7.13;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase;
DE   AltName: Full=GDP-mannose pyrophosphorylase;
GN   Name=mpg1; ORFNames=AFUA_4G11510;
OS   Aspergillus fumigatus (Sartorya fumigata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae;
OC   mitosporic Trichocomaceae; Aspergillus.
OX   NCBI_TaxID=5085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=YJ-407;
RA   Jiang H., Jin C.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S.,
RA   Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W.,
RA   Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S.,
RA   Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R.,
RA   Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A.,
RA   Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J.,
RA   Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J.,
RA   Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S.,
RA   Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A.,
RA   Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M.,
RA   Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I.,
RA   Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M.,
RA   Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S.,
RA   Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J.,
RA   White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K.,
RA   Machida M., Hall N., Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Involved in cell wall synthesis where it is required for
CC       glycosylation. Involved in cell cycle progression through cell-
CC       size checkpoint (By similarity).
CC   -!- CATALYTIC ACTIVITY: GTP + alpha-D-mannose 1-phosphate =
CC       diphosphate + GDP-mannose.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL89641.1; Type=Erroneous gene model prediction;
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DR   EMBL; DQ017035; AAY40351.1; -; mRNA.
DR   EMBL; AAHF01000005; EAL89641.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_751679.1; -.
DR   GeneID; 3509467; -.
DR   KEGG; afm:AFUA_4G11510; -.
DR   HOGENOM; Q4U3E8; -.
DR   BRENDA; 2.7.7.13; 18841.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase act...; IEA:EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR001451; Hexapep_transf.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase.
DR   Pfam; PF00132; Hexapep; 4.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Complete proteome; Cytoplasm; GTP-binding;
KW   Nucleotide-binding; Nucleotidyltransferase; Transferase.
FT   CHAIN         1    364       Mannose-1-phosphate guanyltransferase.
FT                                /FTId=PRO_0000238483.
SQ   SEQUENCE   364 AA;  40124 MW;  FA27CFFF93BFF51D CRC64;
     MKALILVGGF GTRLRPLTLT LPKPLVEFGN RPMILHQVES LAAAGVTDIV LAVNYRPDVM
     VAALKKYEEQ YNVRIEFSVE SEPLGTAGPL KLAEKILGKD DSPFFVLNSD IICDYPFKQL
     AEFHKKHGDE GTIVVTKVDE PSKYGVVVHK PNHPSRIDRF VEKPVEFVGN RINAGIYILN
     PSVLKRIELR PTSIEQETFP AICSDGQLHS FDLEGFWMDV GQPKDFLTGT CLYLTSLAKR
     NSKLLAPNSE PYVYGGNVMV DPSAKIGKNC RIGPNVVIGP NVVVGDGVRL QRCVLLENSK
     VKDHAWIKST IVGWNSSVGK WARLENVTVL GDDVTIADEV YVNGGSILPH KSIKQNIDVP
     AIIM
//