Reviewed, UniProtKB/Swiss-Prot Q4U3E8 (MPG1_ASPFU)

Names and origin

Protein names

Recommended name:
    Mannose-1-phosphate guanyltransferase
    EC=2.7.7.13
Alternative name(s):
    GTP-mannose-1-phosphate guanylyltransferase
    GDP-mannose pyrophosphorylase

Gene names

Name:	mpg1
ORF Names:	AFUA_4G11510

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint By similarity.
Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.
Sequence caution	The sequence EAL89641.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Mannose-1-phosphate guanyltransferase		PRO_0000238483

Sequences

	Sequence		Length	Mass (Da)
	Q4U3E8-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: FA27CFFF93BFF51D	FASTA	364	40,124
	10 20 30 40 50 60 MKALILVGGF GTRLRPLTLT LPKPLVEFGN RPMILHQVES LAAAGVTDIV LAVNYRPDVM 70 80 90 100 110 120 VAALKKYEEQ YNVRIEFSVE SEPLGTAGPL KLAEKILGKD DSPFFVLNSD IICDYPFKQL 130 140 150 160 170 180 AEFHKKHGDE GTIVVTKVDE PSKYGVVVHK PNHPSRIDRF VEKPVEFVGN RINAGIYILN 190 200 210 220 230 240 PSVLKRIELR PTSIEQETFP AICSDGQLHS FDLEGFWMDV GQPKDFLTGT CLYLTSLAKR 250 260 270 280 290 300 NSKLLAPNSE PYVYGGNVMV DPSAKIGKNC RIGPNVVIGP NVVVGDGVRL QRCVLLENSK 310 320 330 340 350 360 VKDHAWIKST IVGWNSSVGK WARLENVTVL GDDVTIADEV YVNGGSILPH KSIKQNIDVP AIIM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Jiang H., Jin C. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: YJ-407.
[2]	"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ017035 mRNA. Translation: AAY40351.1. AAHF01000005 Genomic DNA. Translation: EAL89641.1. Sequence problems.
RefSeq	XP_751679.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3509467.
KEGG	afm:AFUA_4G11510.
Phylogenomic databases
HOGENOM	Q4U3E8.
Enzyme and pathway databases
BRENDA	2.7.7.13. 18841.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00132. Hexapep. 4 hits. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPG1_ASPFU

Accession

Primary (citable) accession number: Q4U3E8
Secondary accession number(s): Q4WQ43

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	July 5, 2005
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)