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Q4U2R8 (S22A6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 22 member 6
Alternative name(s):
Organic anion transporter 1
Short name=hOAT1
PAH transporter
Short name=hPAHT
Renal organic anion transporter 1
Short name=hROAT1
Gene names
Name:SLC22A6
Synonyms:OAT1, PAHT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length563 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) By similarity. Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid By similarity. PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate. Ref.1 Ref.2 Ref.11 Ref.14 Ref.16 Ref.17

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Tissue specificity

Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule. Ref.2 Ref.3 Ref.4 Ref.5 Ref.6

Domain

Multiple cysteine residues are necessary for proper targeting to the plasma membrane By similarity.

Post-translational modification

Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane. Ref.5 Ref.12

Sequence similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]

Biophysicochemical properties

Kinetic parameters:

KM=9.3 µM for PAH (isoform 1) Ref.5 Ref.6 Ref.11 Ref.15

KM=4 µM for PAH (isoform 2)

KM=11 µM for edaravone

KM=46 µM for cidofovir

KM=30 µM for adefovir

KM=5.77 µM for 2,4-D

KM=23.5 µM for HA

KM=14 µM for IA

KM=20.5 µM for IS

KM=141 µM for CMPF

Vmax=534 pmol/min/mg enzyme for 2,4-D uptake

Vmax=430 pmol/min/mg enzyme for HA uptake

Vmax=110 pmol/min/mg enzyme for IA uptake

Vmax=216 pmol/min/mg enzyme for IS uptake

Vmax=801 pmol/min/mg enzyme for CMPF uptake

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processalpha-ketoglutarate transport

Inferred from direct assay Ref.3. Source: UniProtKB

organic anion transport

Inferred from direct assay Ref.4Ref.3. Source: UniProtKB

protein homooligomerization

Inferred from electronic annotation. Source: Ensembl

renal tubular secretion

Inferred from mutant phenotype PubMed 22169006. Source: UniProtKB

response to methotrexate

Inferred from electronic annotation. Source: Ensembl

sodium-independent organic anion transport

Inferred from direct assay Ref.2. Source: UniProtKB

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentbasolateral plasma membrane

Inferred from direct assay PubMed 15037815Ref.2. Source: UniProtKB

caveola

Inferred from electronic annotation. Source: Ensembl

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867. Source: UniProt

integral component of plasma membrane

Inferred from direct assay Ref.12. Source: UniProtKB

plasma membrane

Traceable author statement. Source: Reactome

protein complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionchloride ion binding

Inferred from electronic annotation. Source: Ensembl

inorganic anion exchanger activity

Inferred from direct assay PubMed 15037815. Source: UniProtKB

organic anion transmembrane transporter activity

Inferred from direct assay Ref.4Ref.3. Source: UniProtKB

sodium-independent organic anion transmembrane transporter activity

Inferred from direct assay Ref.2. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

APPBP2Q926243EBI-749741,EBI-743771

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q4U2R8-1)

Also known as: OAT1-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q4U2R8-2)

Also known as: OAT1-2;

The sequence of this isoform differs from the canonical sequence as follows:
     523-535: Missing.
Isoform 3 (identifier: Q4U2R8-3)

Also known as: OAT1-3;

The sequence of this isoform differs from the canonical sequence as follows:
     455-498: Missing.
     523-535: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q4U2R8-4)

Also known as: OAT1-4;

The sequence of this isoform differs from the canonical sequence as follows:
     455-498: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 563563Solute carrier family 22 member 6
PRO_0000324166

Regions

Topological domain1 – 99Cytoplasmic Potential
Transmembrane10 – 3021Helical; Potential
Topological domain31 – 135105Extracellular Potential
Transmembrane136 – 15621Helical; Potential
Topological domain157 – 1648Cytoplasmic Potential
Transmembrane165 – 18723Helical; Potential
Topological domain188 – 1903Extracellular Potential
Transmembrane191 – 21323Helical; Potential
Topological domain214 – 22411Cytoplasmic Potential
Transmembrane225 – 24521Helical; Potential
Topological domain246 – 2483Extracellular Potential
Transmembrane249 – 26921Helical; Potential
Topological domain270 – 33768Cytoplasmic Potential
Transmembrane338 – 35821Helical; Potential
Topological domain359 – 36810Extracellular Potential
Transmembrane369 – 38921Helical; Potential
Topological domain390 – 3956Cytoplasmic Potential
Transmembrane396 – 41621Helical; Potential
Topological domain417 – 4259Extracellular Potential
Transmembrane426 – 44621Helical; Potential
Topological domain447 – 4559Cytoplasmic Potential
Transmembrane456 – 47520Helical; Potential
Topological domain476 – 4849Extracellular Potential
Transmembrane485 – 50521Helical; Potential
Topological domain506 – 56358Cytoplasmic Potential

Sites

Site2301Important for interaction with cidofovir
Site4381Important for interaction with cidofovir and PAH

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) Ref.12
Glycosylation561N-linked (GlcNAc...) Ref.12
Glycosylation921N-linked (GlcNAc...) Ref.12
Glycosylation971N-linked (GlcNAc...) Ref.12
Glycosylation1131N-linked (GlcNAc...)

Natural variations

Alternative sequence455 – 49844Missing in isoform 3 and isoform 4.
VSP_032168
Alternative sequence523 – 53513Missing in isoform 2 and isoform 3.
VSP_032169
Natural variant71L → P. Ref.19
VAR_039682
Natural variant501R → H Lower Vmax; increase in substrate affinity and increase in the affinity for the nucleoside phosphonate analogs cidofovir, adefovir and tenofovir. Ref.18 Ref.19
Corresponds to variant rs11568626 [ dbSNP | Ensembl ].
VAR_039683
Natural variant1041P → L. Ref.7
Corresponds to variant rs11568627 [ dbSNP | Ensembl ].
VAR_047878
Natural variant2931R → W Increase in substrate affinity.
Corresponds to variant rs45607933 [ dbSNP | Ensembl ].
VAR_039684

Experimental info

Mutagenesis301L → A: Complete loss of PAH transport activity. Ref.13
Mutagenesis361T → A: Complete loss of PAH transport activity. Ref.13
Mutagenesis391N → Q: Complete loss of PAH transport activity. Ref.12
Mutagenesis2301Y → A: Loss of membrane protein expression and little uptake of cidofovir. Ref.16
Mutagenesis4311K → A: Decrease in the level of membrane protein expression and 70 % loss of PAH uptake. Ref.16
Mutagenesis4381F → A: Decrease in the level of membrane protein expression, 70 % loss of PAH uptake, increased affinity for cidofovir, lower Vmax for PAH, and lower Km and Vmax for cidofovir. Ref.16
Sequence conflict141G → S in AAD10052. Ref.3
Sequence conflict5631L → F in AAC70004. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (OAT1-1) [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 74AD3EA2678032E4

FASTA56361,816
        10         20         30         40         50         60 
MAFNDLLQQV GGVGRFQQIQ VTLVVLPLLL MASHNTLQNF TAAIPTHHCR PPADANLSKN 

        70         80         90        100        110        120 
GGLEVWLPRD RQGQPESCLR FTSPQWGLPF LNGTEANGTG ATEPCTDGWI YDNSTFPSTI 

       130        140        150        160        170        180 
VTEWDLVCSH RALRQLAQSL YMVGVLLGAM VFGYLADRLG RRKVLILNYL QTAVSGTCAA 

       190        200        210        220        230        240 
FAPNFPIYCA FRLLSGMALA GISLNCMTLN VEWMPIHTRA CVGTLIGYVY SLGQFLLAGV 

       250        260        270        280        290        300 
AYAVPHWRHL QLLVSAPFFA FFIYSWFFIE SARWHSSSGR LDLTLRALQR VARINGKREE 

       310        320        330        340        350        360 
GAKLSMEVLR ASLQKELTMG KGQASAMELL RCPTLRHLFL CLSMLWFATS FAYYGLVMDL 

       370        380        390        400        410        420 
QGFGVSIYLI QVIFGAVDLP AKLVGFLVIN SLGRRPAQMA ALLLAGICIL LNGVIPQDQS 

       430        440        450        460        470        480 
IVRTSLAVLG KGCLAASFNC IFLYTGELYP TMIRQTGMGM GSTMARVGSI VSPLVSMTAE 

       490        500        510        520        530        540 
LYPSMPLFIY GAVPVAASAV TVLLPETLGQ PLPDTVQDLE SRWAPTQKEA GIYPRKGKQT 

       550        560 
RQQQEHQKYM VPLQASAQEK NGL 

« Hide

Isoform 2 (OAT1-2) [UniParc].

Checksum: BC5D6DBDD0072D92
Show »

FASTA55060,318
Isoform 3 (OAT1-3) [UniParc].

Checksum: D8EBAE8A113E6C5E
Show »

FASTA50655,858
Isoform 4 (OAT1-4) [UniParc].

Checksum: E1748C6F9E2002F2
Show »

FASTA51957,357

References

« Hide 'large scale' references
[1]"Cloning of a human renal p-aminohippurate transporter, hROAT1."
Reid G., Wolff N.A., Dautzenberg F.M., Burckhardt G.
Kidney Blood Press. Res. 21:233-237(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
[2]"Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney."
Hosoyamada M., Sekine T., Kanai Y., Endou H.
Am. J. Physiol. 276:F122-F128(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, FUNCTION.
Tissue: Kidney.
[3]"Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C."
Lu R., Chan B.S., Schuster V.L.
Am. J. Physiol. 276:F295-F303(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
Tissue: Kidney.
[4]"Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)."
Race J.E., Grassl S.M., Williams W.J., Holtzman E.J.
Biochem. Biophys. Res. Commun. 255:508-514(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
Tissue: Kidney.
[5]"The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1."
Cihlar T., Lin D.C., Pritchard J.B., Fuller M.D., Mendel D.B., Sweet D.H.
Mol. Pharmacol. 56:570-580(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), GLYCOSYLATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
Tissue: Kidney.
[6]"Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene."
Bahn A., Prawitt D., Buttler D., Reid G., Enklaar T., Wolff N.A., Ebbinghaus C., Hillemann A., Schulten H.-J., Gunawan B., Fuezesi L., Zabel B., Burckhardt G.
Biochem. Biophys. Res. Commun. 275:623-630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 3 AND 4), BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
Tissue: Kidney.
[7]NIEHS SNPs program
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-104.
[8]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Colon.
[11]"Interaction of cysteine conjugates with human and rabbit organic anion transporter 1."
Groves C.E., Munoz L., Bahn A., Burckhardt G., Wright S.H.
J. Pharmacol. Exp. Ther. 304:560-566(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
[12]"Role of glycosylation in the organic anion transporter OAT1."
Tanaka K., Xu W., Zhou F., You G.
J. Biol. Chem. 279:14961-14966(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS OF ASN-39, GLYCOSYLATION AT ASN-39; ASN-56; ASN-92 AND ASN-97.
[13]"Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1."
Hong M., Zhou F., You G.
J. Biol. Chem. 279:31478-31482(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS OF LEU-30 AND THR-36.
[14]"Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)."
Srimaroeng C., Chatsudthipong V., Aslamkhan A.G., Pritchard J.B.
J. Pharmacol. Exp. Ther. 313:621-628(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[15]"Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney."
Tahara H., Shono M., Kusuhara H., Kinoshita H., Fuse E., Takadate A., Otagiri M., Sugiyama Y.
Pharm. Res. 22:647-660(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: BIOPHYSICOCHEMICAL PROPERTIES.
[16]"A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport."
Perry J.L., Dembla-Rajpal N., Hall L.A., Pritchard J.B.
J. Biol. Chem. 281:38071-38079(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS OF TYR-230; LYS-431 AND PHE-438, SUBSTRATE-BINDING SITES, FUNCTION.
[17]"Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate."
Mizuno N., Takahashi T., Iwase Y., Kusuhara H., Niwa T., Sugiyama Y.
Drug Metab. Dispos. 35:1429-1434(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[18]"Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6)."
Bleasby K., Hall L.A., Perry J.L., Mohrenweiser H.W., Pritchard J.B.
J. Pharmacol. Exp. Ther. 314:923-931(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HIS-50, CHARACTERIZATION OF VARIANT HIS-50.
[19]"Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]."
Xu G., Bhatnagar V., Wen G., Hamilton B.A., Eraly S.A., Nigam S.K.
Kidney Int. 68:1491-1499(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PRO-7 AND HIS-50.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF057039 mRNA. Translation: AAC70004.1.
AB009697 mRNA. Translation: BAA75072.1.
AB009698 mRNA. Translation: BAA75073.1.
AF104038 mRNA. Translation: AAD10052.1.
AF097490 mRNA. Translation: AAD19356.1.
AF124373 mRNA. Translation: AAD55356.1.
AJ249369 Genomic DNA. Translation: CAB77184.1.
AJ251529 mRNA. Translation: CAB94830.1.
AJ271205 mRNA. Translation: CAB97249.1.
EU567146 Genomic DNA. Translation: ACB21049.1.
AP001858 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74129.1.
CH471076 Genomic DNA. Translation: EAW74130.1.
CH471076 Genomic DNA. Translation: EAW74131.1.
CH471076 Genomic DNA. Translation: EAW74132.1.
BC033682 mRNA. Translation: AAH33682.1.
RefSeqNP_004781.2. NM_004790.4.
NP_695008.1. NM_153276.2.
NP_695009.1. NM_153277.2.
NP_695010.1. NM_153278.2.
UniGeneHs.369252.

3D structure databases

ProteinModelPortalQ4U2R8.
SMRQ4U2R8. Positions 139-524.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114759. 2 interactions.
IntActQ4U2R8. 1 interaction.
MINTMINT-1474237.

Chemistry

BindingDBQ4U2R8.
ChEMBLCHEMBL1641347.

Protein family/group databases

TCDB2.A.1.19.31. the major facilitator superfamily (mfs).

Polymorphism databases

DMDM74762955.

Proteomic databases

PaxDbQ4U2R8.
PRIDEQ4U2R8.

Protocols and materials databases

DNASU9356.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360421; ENSP00000353597; ENSG00000197901. [Q4U2R8-2]
ENST00000377871; ENSP00000367102; ENSG00000197901. [Q4U2R8-1]
ENST00000421062; ENSP00000404441; ENSG00000197901. [Q4U2R8-4]
ENST00000458333; ENSP00000396401; ENSG00000197901. [Q4U2R8-3]
GeneID9356.
KEGGhsa:9356.
UCSCuc001nwj.3. human. [Q4U2R8-2]
uc001nwk.3. human. [Q4U2R8-1]
uc001nwl.3. human. [Q4U2R8-3]
uc001nwm.3. human. [Q4U2R8-4]

Organism-specific databases

CTD9356.
GeneCardsGC11M062744.
HGNCHGNC:10970. SLC22A6.
MIM607582. gene.
neXtProtNX_Q4U2R8.
PharmGKBPA388.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOVERGENHBG108433.
InParanoidQ4U2R8.
KOK08203.
OMAMIRQTGM.
OrthoDBEOG7C8GH9.
PhylomeDBQ4U2R8.
TreeFamTF315847.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ4U2R8.
BgeeQ4U2R8.
GenevestigatorQ4U2R8.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
TIGRFAMsTIGR00898. 2A0119. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOrganic_anion_transporter_1.
GenomeRNAi9356.
NextBio35037.
PROQ4U2R8.
SOURCESearch...

Entry information

Entry nameS22A6_HUMAN
AccessionPrimary (citable) accession number: Q4U2R8
Secondary accession number(s): A8MY93 expand/collapse secondary AC list , B2D0R6, O95187, O95742, Q7LDA0, Q8N192, Q9NQA6, Q9NQC2, Q9UBG6, Q9UEQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM