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Q4U2R8

- S22A6_HUMAN

UniProt

Q4U2R8 - S22A6_HUMAN

Protein

Solute carrier family 22 member 6

Gene

SLC22A6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) By similarity. Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid By similarity. PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.By similarity6 Publications

    Kineticsi

    1. KM=9.3 µM for PAH (isoform 1)4 Publications
    2. KM=4 µM for PAH (isoform 2)4 Publications
    3. KM=11 µM for edaravone4 Publications
    4. KM=46 µM for cidofovir4 Publications
    5. KM=30 µM for adefovir4 Publications
    6. KM=5.77 µM for 2,4-D4 Publications
    7. KM=23.5 µM for HA4 Publications
    8. KM=14 µM for IA4 Publications
    9. KM=20.5 µM for IS4 Publications
    10. KM=141 µM for CMPF4 Publications

    Vmax=534 pmol/min/mg enzyme for 2,4-D uptake4 Publications

    Vmax=430 pmol/min/mg enzyme for HA uptake4 Publications

    Vmax=110 pmol/min/mg enzyme for IA uptake4 Publications

    Vmax=216 pmol/min/mg enzyme for IS uptake4 Publications

    Vmax=801 pmol/min/mg enzyme for CMPF uptake4 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei230 – 2301Important for interaction with cidofovir
    Sitei438 – 4381Important for interaction with cidofovir and PAH

    GO - Molecular functioni

    1. chloride ion binding Source: Ensembl
    2. inorganic anion exchanger activity Source: UniProtKB
    3. organic anion transmembrane transporter activity Source: UniProtKB
    4. protein binding Source: IntAct
    5. sodium-independent organic anion transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. alpha-ketoglutarate transport Source: UniProtKB
    2. organic anion transport Source: UniProtKB
    3. protein homooligomerization Source: Ensembl
    4. renal tubular secretion Source: UniProtKB
    5. response to methotrexate Source: Ensembl
    6. sodium-independent organic anion transport Source: UniProtKB
    7. transmembrane transport Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_22310. Organic anion transport.

    Protein family/group databases

    TCDBi2.A.1.19.31. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 6
    Alternative name(s):
    Organic anion transporter 1
    Short name:
    hOAT1
    PAH transporter
    Short name:
    hPAHT
    Renal organic anion transporter 1
    Short name:
    hROAT1
    Gene namesi
    Name:SLC22A6
    Synonyms:OAT1, PAHT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:10970. SLC22A6.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB
    2. caveola Source: Ensembl
    3. extracellular vesicular exosome Source: UniProt
    4. integral component of plasma membrane Source: UniProtKB
    5. plasma membrane Source: Reactome
    6. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi30 – 301L → A: Complete loss of PAH transport activity. 1 Publication
    Mutagenesisi36 – 361T → A: Complete loss of PAH transport activity. 1 Publication
    Mutagenesisi39 – 391N → Q: Complete loss of PAH transport activity. 1 Publication
    Mutagenesisi230 – 2301Y → A: Loss of membrane protein expression and little uptake of cidofovir. 1 Publication
    Mutagenesisi431 – 4311K → A: Decrease in the level of membrane protein expression and 70 % loss of PAH uptake. 1 Publication
    Mutagenesisi438 – 4381F → A: Decrease in the level of membrane protein expression, 70 % loss of PAH uptake, increased affinity for cidofovir, lower Vmax for PAH, and lower Km and Vmax for cidofovir. 1 Publication

    Organism-specific databases

    PharmGKBiPA388.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 563563Solute carrier family 22 member 6PRO_0000324166Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)2 Publications
    Glycosylationi56 – 561N-linked (GlcNAc...)2 Publications
    Glycosylationi92 – 921N-linked (GlcNAc...)2 Publications
    Glycosylationi97 – 971N-linked (GlcNAc...)2 Publications
    Glycosylationi113 – 1131N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane.2 Publications

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ4U2R8.
    PRIDEiQ4U2R8.

    Expressioni

    Tissue specificityi

    Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule.5 Publications

    Gene expression databases

    ArrayExpressiQ4U2R8.
    BgeeiQ4U2R8.
    GenevestigatoriQ4U2R8.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    APPBP2Q926243EBI-749741,EBI-743771

    Protein-protein interaction databases

    BioGridi114759. 2 interactions.
    IntActiQ4U2R8. 1 interaction.
    MINTiMINT-1474237.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4U2R8.
    SMRiQ4U2R8. Positions 139-524.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99CytoplasmicSequence Analysis
    Topological domaini31 – 135105ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini157 – 1648CytoplasmicSequence Analysis
    Topological domaini188 – 1903ExtracellularSequence Analysis
    Topological domaini214 – 22411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini246 – 2483ExtracellularSequence Analysis
    Topological domaini270 – 33768CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini359 – 36810ExtracellularSequence Analysis
    Topological domaini390 – 3956CytoplasmicSequence Analysis
    Topological domaini417 – 4259ExtracellularSequence Analysis
    Topological domaini447 – 4559CytoplasmicSequence Analysis
    Topological domaini476 – 4849ExtracellularSequence Analysis
    Topological domaini506 – 56358CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei191 – 21323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei249 – 26921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei369 – 38921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei396 – 41621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei426 – 44621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei485 – 50521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    Multiple cysteine residues are necessary for proper targeting to the plasma membrane.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOVERGENiHBG108433.
    InParanoidiQ4U2R8.
    KOiK08203.
    OMAiMIRQTGM.
    OrthoDBiEOG7C8GH9.
    PhylomeDBiQ4U2R8.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004749. Orgcat_transp.
    IPR005828. Sub_transporter.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00898. 2A0119. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q4U2R8-1) [UniParc]FASTAAdd to Basket

    Also known as: OAT1-1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFNDLLQQV GGVGRFQQIQ VTLVVLPLLL MASHNTLQNF TAAIPTHHCR    50
    PPADANLSKN GGLEVWLPRD RQGQPESCLR FTSPQWGLPF LNGTEANGTG 100
    ATEPCTDGWI YDNSTFPSTI VTEWDLVCSH RALRQLAQSL YMVGVLLGAM 150
    VFGYLADRLG RRKVLILNYL QTAVSGTCAA FAPNFPIYCA FRLLSGMALA 200
    GISLNCMTLN VEWMPIHTRA CVGTLIGYVY SLGQFLLAGV AYAVPHWRHL 250
    QLLVSAPFFA FFIYSWFFIE SARWHSSSGR LDLTLRALQR VARINGKREE 300
    GAKLSMEVLR ASLQKELTMG KGQASAMELL RCPTLRHLFL CLSMLWFATS 350
    FAYYGLVMDL QGFGVSIYLI QVIFGAVDLP AKLVGFLVIN SLGRRPAQMA 400
    ALLLAGICIL LNGVIPQDQS IVRTSLAVLG KGCLAASFNC IFLYTGELYP 450
    TMIRQTGMGM GSTMARVGSI VSPLVSMTAE LYPSMPLFIY GAVPVAASAV 500
    TVLLPETLGQ PLPDTVQDLE SRWAPTQKEA GIYPRKGKQT RQQQEHQKYM 550
    VPLQASAQEK NGL 563
    Length:563
    Mass (Da):61,816
    Last modified:July 19, 2005 - v1
    Checksum:i74AD3EA2678032E4
    GO
    Isoform 2 (identifier: Q4U2R8-2) [UniParc]FASTAAdd to Basket

    Also known as: OAT1-2

    The sequence of this isoform differs from the canonical sequence as follows:
         523-535: Missing.

    Show »
    Length:550
    Mass (Da):60,318
    Checksum:iBC5D6DBDD0072D92
    GO
    Isoform 3 (identifier: Q4U2R8-3) [UniParc]FASTAAdd to Basket

    Also known as: OAT1-3

    The sequence of this isoform differs from the canonical sequence as follows:
         455-498: Missing.
         523-535: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:506
    Mass (Da):55,858
    Checksum:iD8EBAE8A113E6C5E
    GO
    Isoform 4 (identifier: Q4U2R8-4) [UniParc]FASTAAdd to Basket

    Also known as: OAT1-4

    The sequence of this isoform differs from the canonical sequence as follows:
         455-498: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:519
    Mass (Da):57,357
    Checksum:iE1748C6F9E2002F2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141G → S in AAD10052. (PubMed:9950961)Curated
    Sequence conflicti563 – 5631L → F in AAC70004. (PubMed:9762842)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71L → P.1 Publication
    VAR_039682
    Natural varianti50 – 501R → H Lower Vmax; increase in substrate affinity and increase in the affinity for the nucleoside phosphonate analogs cidofovir, adefovir and tenofovir. 2 Publications
    Corresponds to variant rs11568626 [ dbSNP | Ensembl ].
    VAR_039683
    Natural varianti104 – 1041P → L.1 Publication
    Corresponds to variant rs11568627 [ dbSNP | Ensembl ].
    VAR_047878
    Natural varianti293 – 2931R → W Increase in substrate affinity.
    Corresponds to variant rs45607933 [ dbSNP | Ensembl ].
    VAR_039684

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei455 – 49844Missing in isoform 3 and isoform 4. 1 PublicationVSP_032168Add
    BLAST
    Alternative sequencei523 – 53513Missing in isoform 2 and isoform 3. 7 PublicationsVSP_032169Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF057039 mRNA. Translation: AAC70004.1.
    AB009697 mRNA. Translation: BAA75072.1.
    AB009698 mRNA. Translation: BAA75073.1.
    AF104038 mRNA. Translation: AAD10052.1.
    AF097490 mRNA. Translation: AAD19356.1.
    AF124373 mRNA. Translation: AAD55356.1.
    AJ249369 Genomic DNA. Translation: CAB77184.1.
    AJ251529 mRNA. Translation: CAB94830.1.
    AJ271205 mRNA. Translation: CAB97249.1.
    EU567146 Genomic DNA. Translation: ACB21049.1.
    AP001858 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74129.1.
    CH471076 Genomic DNA. Translation: EAW74130.1.
    CH471076 Genomic DNA. Translation: EAW74131.1.
    CH471076 Genomic DNA. Translation: EAW74132.1.
    BC033682 mRNA. Translation: AAH33682.1.
    CCDSiCCDS31591.1. [Q4U2R8-1]
    CCDS44631.1. [Q4U2R8-4]
    CCDS44632.1. [Q4U2R8-3]
    CCDS8041.1. [Q4U2R8-2]
    RefSeqiNP_004781.2. NM_004790.4. [Q4U2R8-1]
    NP_695008.1. NM_153276.2. [Q4U2R8-2]
    NP_695009.1. NM_153277.2. [Q4U2R8-3]
    NP_695010.1. NM_153278.2. [Q4U2R8-4]
    UniGeneiHs.369252.

    Genome annotation databases

    EnsembliENST00000360421; ENSP00000353597; ENSG00000197901. [Q4U2R8-2]
    ENST00000377871; ENSP00000367102; ENSG00000197901. [Q4U2R8-1]
    ENST00000421062; ENSP00000404441; ENSG00000197901. [Q4U2R8-4]
    ENST00000458333; ENSP00000396401; ENSG00000197901. [Q4U2R8-3]
    GeneIDi9356.
    KEGGihsa:9356.
    UCSCiuc001nwj.3. human. [Q4U2R8-2]
    uc001nwk.3. human. [Q4U2R8-1]
    uc001nwl.3. human. [Q4U2R8-3]
    uc001nwm.3. human. [Q4U2R8-4]

    Polymorphism databases

    DMDMi74762955.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF057039 mRNA. Translation: AAC70004.1 .
    AB009697 mRNA. Translation: BAA75072.1 .
    AB009698 mRNA. Translation: BAA75073.1 .
    AF104038 mRNA. Translation: AAD10052.1 .
    AF097490 mRNA. Translation: AAD19356.1 .
    AF124373 mRNA. Translation: AAD55356.1 .
    AJ249369 Genomic DNA. Translation: CAB77184.1 .
    AJ251529 mRNA. Translation: CAB94830.1 .
    AJ271205 mRNA. Translation: CAB97249.1 .
    EU567146 Genomic DNA. Translation: ACB21049.1 .
    AP001858 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74129.1 .
    CH471076 Genomic DNA. Translation: EAW74130.1 .
    CH471076 Genomic DNA. Translation: EAW74131.1 .
    CH471076 Genomic DNA. Translation: EAW74132.1 .
    BC033682 mRNA. Translation: AAH33682.1 .
    CCDSi CCDS31591.1. [Q4U2R8-1 ]
    CCDS44631.1. [Q4U2R8-4 ]
    CCDS44632.1. [Q4U2R8-3 ]
    CCDS8041.1. [Q4U2R8-2 ]
    RefSeqi NP_004781.2. NM_004790.4. [Q4U2R8-1 ]
    NP_695008.1. NM_153276.2. [Q4U2R8-2 ]
    NP_695009.1. NM_153277.2. [Q4U2R8-3 ]
    NP_695010.1. NM_153278.2. [Q4U2R8-4 ]
    UniGenei Hs.369252.

    3D structure databases

    ProteinModelPortali Q4U2R8.
    SMRi Q4U2R8. Positions 139-524.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114759. 2 interactions.
    IntActi Q4U2R8. 1 interaction.
    MINTi MINT-1474237.

    Chemistry

    BindingDBi Q4U2R8.
    ChEMBLi CHEMBL1641347.
    GuidetoPHARMACOLOGYi 1025.

    Protein family/group databases

    TCDBi 2.A.1.19.31. the major facilitator superfamily (mfs).

    Polymorphism databases

    DMDMi 74762955.

    Proteomic databases

    PaxDbi Q4U2R8.
    PRIDEi Q4U2R8.

    Protocols and materials databases

    DNASUi 9356.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360421 ; ENSP00000353597 ; ENSG00000197901 . [Q4U2R8-2 ]
    ENST00000377871 ; ENSP00000367102 ; ENSG00000197901 . [Q4U2R8-1 ]
    ENST00000421062 ; ENSP00000404441 ; ENSG00000197901 . [Q4U2R8-4 ]
    ENST00000458333 ; ENSP00000396401 ; ENSG00000197901 . [Q4U2R8-3 ]
    GeneIDi 9356.
    KEGGi hsa:9356.
    UCSCi uc001nwj.3. human. [Q4U2R8-2 ]
    uc001nwk.3. human. [Q4U2R8-1 ]
    uc001nwl.3. human. [Q4U2R8-3 ]
    uc001nwm.3. human. [Q4U2R8-4 ]

    Organism-specific databases

    CTDi 9356.
    GeneCardsi GC11M062744.
    HGNCi HGNC:10970. SLC22A6.
    MIMi 607582. gene.
    neXtProti NX_Q4U2R8.
    PharmGKBi PA388.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOVERGENi HBG108433.
    InParanoidi Q4U2R8.
    KOi K08203.
    OMAi MIRQTGM.
    OrthoDBi EOG7C8GH9.
    PhylomeDBi Q4U2R8.
    TreeFami TF315847.

    Enzyme and pathway databases

    Reactomei REACT_22310. Organic anion transport.

    Miscellaneous databases

    GeneWikii Organic_anion_transporter_1.
    GenomeRNAii 9356.
    NextBioi 35037.
    PROi Q4U2R8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q4U2R8.
    Bgeei Q4U2R8.
    Genevestigatori Q4U2R8.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004749. Orgcat_transp.
    IPR005828. Sub_transporter.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00898. 2A0119. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a human renal p-aminohippurate transporter, hROAT1."
      Reid G., Wolff N.A., Dautzenberg F.M., Burckhardt G.
      Kidney Blood Press. Res. 21:233-237(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
    2. "Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney."
      Hosoyamada M., Sekine T., Kanai Y., Endou H.
      Am. J. Physiol. 276:F122-F128(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, FUNCTION.
      Tissue: Kidney.
    3. "Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C."
      Lu R., Chan B.S., Schuster V.L.
      Am. J. Physiol. 276:F295-F303(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: Kidney.
    4. "Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)."
      Race J.E., Grassl S.M., Williams W.J., Holtzman E.J.
      Biochem. Biophys. Res. Commun. 255:508-514(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: Kidney.
    5. "The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1."
      Cihlar T., Lin D.C., Pritchard J.B., Fuller M.D., Mendel D.B., Sweet D.H.
      Mol. Pharmacol. 56:570-580(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), GLYCOSYLATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
      Tissue: Kidney.
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 3 AND 4), BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
      Tissue: Kidney.
    7. NIEHS SNPs program
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-104.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Colon.
    11. "Interaction of cysteine conjugates with human and rabbit organic anion transporter 1."
      Groves C.E., Munoz L., Bahn A., Burckhardt G., Wright S.H.
      J. Pharmacol. Exp. Ther. 304:560-566(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
    12. "Role of glycosylation in the organic anion transporter OAT1."
      Tanaka K., Xu W., Zhou F., You G.
      J. Biol. Chem. 279:14961-14966(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF ASN-39, GLYCOSYLATION AT ASN-39; ASN-56; ASN-92 AND ASN-97.
    13. "Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1."
      Hong M., Zhou F., You G.
      J. Biol. Chem. 279:31478-31482(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF LEU-30 AND THR-36.
    14. "Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)."
      Srimaroeng C., Chatsudthipong V., Aslamkhan A.G., Pritchard J.B.
      J. Pharmacol. Exp. Ther. 313:621-628(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    15. "Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney."
      Tahara H., Shono M., Kusuhara H., Kinoshita H., Fuse E., Takadate A., Otagiri M., Sugiyama Y.
      Pharm. Res. 22:647-660(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: BIOPHYSICOCHEMICAL PROPERTIES.
    16. "A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport."
      Perry J.L., Dembla-Rajpal N., Hall L.A., Pritchard J.B.
      J. Biol. Chem. 281:38071-38079(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF TYR-230; LYS-431 AND PHE-438, SUBSTRATE-BINDING SITES, FUNCTION.
    17. "Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate."
      Mizuno N., Takahashi T., Iwase Y., Kusuhara H., Niwa T., Sugiyama Y.
      Drug Metab. Dispos. 35:1429-1434(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    18. "Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6)."
      Bleasby K., Hall L.A., Perry J.L., Mohrenweiser H.W., Pritchard J.B.
      J. Pharmacol. Exp. Ther. 314:923-931(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HIS-50, CHARACTERIZATION OF VARIANT HIS-50.
    19. "Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]."
      Xu G., Bhatnagar V., Wen G., Hamilton B.A., Eraly S.A., Nigam S.K.
      Kidney Int. 68:1491-1499(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS PRO-7 AND HIS-50.

    Entry informationi

    Entry nameiS22A6_HUMAN
    AccessioniPrimary (citable) accession number: Q4U2R8
    Secondary accession number(s): A8MY93
    , B2D0R6, O95187, O95742, Q7LDA0, Q8N192, Q9NQA6, Q9NQC2, Q9UBG6, Q9UEQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3