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Q4U2R8

- S22A6_HUMAN

UniProt

Q4U2R8 - S22A6_HUMAN

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Protein

Solute carrier family 22 member 6

Gene

SLC22A6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.By similarity6 Publications

Kineticsi

  1. KM=9.3 µM for PAH (isoform 1)4 Publications
  2. KM=4 µM for PAH (isoform 2)4 Publications
  3. KM=11 µM for edaravone4 Publications
  4. KM=46 µM for cidofovir4 Publications
  5. KM=30 µM for adefovir4 Publications
  6. KM=5.77 µM for 2,4-D4 Publications
  7. KM=23.5 µM for HA4 Publications
  8. KM=14 µM for IA4 Publications
  9. KM=20.5 µM for IS4 Publications
  10. KM=141 µM for CMPF4 Publications

Vmax=534 pmol/min/mg enzyme for 2,4-D uptake4 Publications

Vmax=430 pmol/min/mg enzyme for HA uptake4 Publications

Vmax=110 pmol/min/mg enzyme for IA uptake4 Publications

Vmax=216 pmol/min/mg enzyme for IS uptake4 Publications

Vmax=801 pmol/min/mg enzyme for CMPF uptake4 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei230 – 2301Important for interaction with cidofovir
Sitei438 – 4381Important for interaction with cidofovir and PAH

GO - Molecular functioni

  1. chloride ion binding Source: Ensembl
  2. inorganic anion exchanger activity Source: UniProtKB
  3. organic anion transmembrane transporter activity Source: UniProtKB
  4. sodium-independent organic anion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. alpha-ketoglutarate transport Source: UniProtKB
  2. organic anion transport Source: UniProtKB
  3. protein homooligomerization Source: Ensembl
  4. renal tubular secretion Source: UniProtKB
  5. response to methotrexate Source: Ensembl
  6. sodium-independent organic anion transport Source: UniProtKB
  7. transmembrane transport Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_22310. Organic anion transport.

Protein family/group databases

TCDBi2.A.1.19.31. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 6
Alternative name(s):
Organic anion transporter 1
Short name:
hOAT1
PAH transporter
Short name:
hPAHT
Renal organic anion transporter 1
Short name:
hROAT1
Gene namesi
Name:SLC22A6
Synonyms:OAT1, PAHT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:10970. SLC22A6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence Analysis
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST
Topological domaini31 – 135105ExtracellularSequence AnalysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST
Topological domaini157 – 1648CytoplasmicSequence Analysis
Transmembranei165 – 18723HelicalSequence AnalysisAdd
BLAST
Topological domaini188 – 1903ExtracellularSequence Analysis
Transmembranei191 – 21323HelicalSequence AnalysisAdd
BLAST
Topological domaini214 – 22411CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST
Topological domaini246 – 2483ExtracellularSequence Analysis
Transmembranei249 – 26921HelicalSequence AnalysisAdd
BLAST
Topological domaini270 – 33768CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei338 – 35821HelicalSequence AnalysisAdd
BLAST
Topological domaini359 – 36810ExtracellularSequence Analysis
Transmembranei369 – 38921HelicalSequence AnalysisAdd
BLAST
Topological domaini390 – 3956CytoplasmicSequence Analysis
Transmembranei396 – 41621HelicalSequence AnalysisAdd
BLAST
Topological domaini417 – 4259ExtracellularSequence Analysis
Transmembranei426 – 44621HelicalSequence AnalysisAdd
BLAST
Topological domaini447 – 4559CytoplasmicSequence Analysis
Transmembranei456 – 47520HelicalSequence AnalysisAdd
BLAST
Topological domaini476 – 4849ExtracellularSequence Analysis
Transmembranei485 – 50521HelicalSequence AnalysisAdd
BLAST
Topological domaini506 – 56358CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB
  2. caveola Source: Ensembl
  3. extracellular vesicular exosome Source: UniProt
  4. integral component of plasma membrane Source: UniProtKB
  5. plasma membrane Source: Reactome
  6. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi30 – 301L → A: Complete loss of PAH transport activity. 1 Publication
Mutagenesisi36 – 361T → A: Complete loss of PAH transport activity. 1 Publication
Mutagenesisi39 – 391N → Q: Complete loss of PAH transport activity. 1 Publication
Mutagenesisi230 – 2301Y → A: Loss of membrane protein expression and little uptake of cidofovir. 1 Publication
Mutagenesisi431 – 4311K → A: Decrease in the level of membrane protein expression and 70 % loss of PAH uptake. 1 Publication
Mutagenesisi438 – 4381F → A: Decrease in the level of membrane protein expression, 70 % loss of PAH uptake, increased affinity for cidofovir, lower Vmax for PAH, and lower Km and Vmax for cidofovir. 1 Publication

Organism-specific databases

PharmGKBiPA388.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Solute carrier family 22 member 6PRO_0000324166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)1 Publication
Glycosylationi56 – 561N-linked (GlcNAc...)1 Publication
Glycosylationi92 – 921N-linked (GlcNAc...)1 Publication
Glycosylationi97 – 971N-linked (GlcNAc...)1 Publication
Glycosylationi113 – 1131N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4U2R8.
PRIDEiQ4U2R8.

Expressioni

Tissue specificityi

Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule.5 Publications

Gene expression databases

BgeeiQ4U2R8.
ExpressionAtlasiQ4U2R8. baseline and differential.
GenevestigatoriQ4U2R8.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-749741,EBI-743771

Protein-protein interaction databases

BioGridi114759. 2 interactions.
IntActiQ4U2R8. 1 interaction.
MINTiMINT-1474237.

Structurei

3D structure databases

ProteinModelPortaliQ4U2R8.
SMRiQ4U2R8. Positions 106-524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Multiple cysteine residues are necessary for proper targeting to the plasma membrane.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOVERGENiHBG108433.
InParanoidiQ4U2R8.
KOiK08203.
OMAiMIRQTGM.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ4U2R8.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q4U2R8-1) [UniParc]FASTAAdd to Basket

Also known as: OAT1-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFNDLLQQV GGVGRFQQIQ VTLVVLPLLL MASHNTLQNF TAAIPTHHCR
60 70 80 90 100
PPADANLSKN GGLEVWLPRD RQGQPESCLR FTSPQWGLPF LNGTEANGTG
110 120 130 140 150
ATEPCTDGWI YDNSTFPSTI VTEWDLVCSH RALRQLAQSL YMVGVLLGAM
160 170 180 190 200
VFGYLADRLG RRKVLILNYL QTAVSGTCAA FAPNFPIYCA FRLLSGMALA
210 220 230 240 250
GISLNCMTLN VEWMPIHTRA CVGTLIGYVY SLGQFLLAGV AYAVPHWRHL
260 270 280 290 300
QLLVSAPFFA FFIYSWFFIE SARWHSSSGR LDLTLRALQR VARINGKREE
310 320 330 340 350
GAKLSMEVLR ASLQKELTMG KGQASAMELL RCPTLRHLFL CLSMLWFATS
360 370 380 390 400
FAYYGLVMDL QGFGVSIYLI QVIFGAVDLP AKLVGFLVIN SLGRRPAQMA
410 420 430 440 450
ALLLAGICIL LNGVIPQDQS IVRTSLAVLG KGCLAASFNC IFLYTGELYP
460 470 480 490 500
TMIRQTGMGM GSTMARVGSI VSPLVSMTAE LYPSMPLFIY GAVPVAASAV
510 520 530 540 550
TVLLPETLGQ PLPDTVQDLE SRWAPTQKEA GIYPRKGKQT RQQQEHQKYM
560
VPLQASAQEK NGL
Length:563
Mass (Da):61,816
Last modified:July 19, 2005 - v1
Checksum:i74AD3EA2678032E4
GO
Isoform 2 (identifier: Q4U2R8-2) [UniParc]FASTAAdd to Basket

Also known as: OAT1-2

The sequence of this isoform differs from the canonical sequence as follows:
     523-535: Missing.

Show »
Length:550
Mass (Da):60,318
Checksum:iBC5D6DBDD0072D92
GO
Isoform 3 (identifier: Q4U2R8-3) [UniParc]FASTAAdd to Basket

Also known as: OAT1-3

The sequence of this isoform differs from the canonical sequence as follows:
     455-498: Missing.
     523-535: Missing.

Note: No experimental confirmation available.

Show »
Length:506
Mass (Da):55,858
Checksum:iD8EBAE8A113E6C5E
GO
Isoform 4 (identifier: Q4U2R8-4) [UniParc]FASTAAdd to Basket

Also known as: OAT1-4

The sequence of this isoform differs from the canonical sequence as follows:
     455-498: Missing.

Note: No experimental confirmation available.

Show »
Length:519
Mass (Da):57,357
Checksum:iE1748C6F9E2002F2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141G → S in AAD10052. (PubMed:9950961)Curated
Sequence conflicti563 – 5631L → F in AAC70004. (PubMed:9762842)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71L → P.1 Publication
VAR_039682
Natural varianti50 – 501R → H Lower Vmax; increase in substrate affinity and increase in the affinity for the nucleoside phosphonate analogs cidofovir, adefovir and tenofovir. 2 Publications
Corresponds to variant rs11568626 [ dbSNP | Ensembl ].
VAR_039683
Natural varianti104 – 1041P → L.1 Publication
Corresponds to variant rs11568627 [ dbSNP | Ensembl ].
VAR_047878
Natural varianti293 – 2931R → W Increase in substrate affinity.
Corresponds to variant rs45607933 [ dbSNP | Ensembl ].
VAR_039684

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei455 – 49844Missing in isoform 3 and isoform 4. 1 PublicationVSP_032168Add
BLAST
Alternative sequencei523 – 53513Missing in isoform 2 and isoform 3. 7 PublicationsVSP_032169Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057039 mRNA. Translation: AAC70004.1.
AB009697 mRNA. Translation: BAA75072.1.
AB009698 mRNA. Translation: BAA75073.1.
AF104038 mRNA. Translation: AAD10052.1.
AF097490 mRNA. Translation: AAD19356.1.
AF124373 mRNA. Translation: AAD55356.1.
AJ249369 Genomic DNA. Translation: CAB77184.1.
AJ251529 mRNA. Translation: CAB94830.1.
AJ271205 mRNA. Translation: CAB97249.1.
EU567146 Genomic DNA. Translation: ACB21049.1.
AP001858 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74129.1.
CH471076 Genomic DNA. Translation: EAW74130.1.
CH471076 Genomic DNA. Translation: EAW74131.1.
CH471076 Genomic DNA. Translation: EAW74132.1.
BC033682 mRNA. Translation: AAH33682.1.
CCDSiCCDS31591.1. [Q4U2R8-1]
CCDS44631.1. [Q4U2R8-4]
CCDS44632.1. [Q4U2R8-3]
CCDS8041.1. [Q4U2R8-2]
RefSeqiNP_004781.2. NM_004790.4. [Q4U2R8-1]
NP_695008.1. NM_153276.2. [Q4U2R8-2]
NP_695009.1. NM_153277.2. [Q4U2R8-3]
NP_695010.1. NM_153278.2. [Q4U2R8-4]
UniGeneiHs.369252.

Genome annotation databases

EnsembliENST00000360421; ENSP00000353597; ENSG00000197901. [Q4U2R8-2]
ENST00000377871; ENSP00000367102; ENSG00000197901. [Q4U2R8-1]
ENST00000421062; ENSP00000404441; ENSG00000197901. [Q4U2R8-4]
ENST00000458333; ENSP00000396401; ENSG00000197901. [Q4U2R8-3]
GeneIDi9356.
KEGGihsa:9356.
UCSCiuc001nwj.3. human. [Q4U2R8-2]
uc001nwk.3. human. [Q4U2R8-1]
uc001nwl.3. human. [Q4U2R8-3]
uc001nwm.3. human. [Q4U2R8-4]

Polymorphism databases

DMDMi74762955.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057039 mRNA. Translation: AAC70004.1 .
AB009697 mRNA. Translation: BAA75072.1 .
AB009698 mRNA. Translation: BAA75073.1 .
AF104038 mRNA. Translation: AAD10052.1 .
AF097490 mRNA. Translation: AAD19356.1 .
AF124373 mRNA. Translation: AAD55356.1 .
AJ249369 Genomic DNA. Translation: CAB77184.1 .
AJ251529 mRNA. Translation: CAB94830.1 .
AJ271205 mRNA. Translation: CAB97249.1 .
EU567146 Genomic DNA. Translation: ACB21049.1 .
AP001858 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74129.1 .
CH471076 Genomic DNA. Translation: EAW74130.1 .
CH471076 Genomic DNA. Translation: EAW74131.1 .
CH471076 Genomic DNA. Translation: EAW74132.1 .
BC033682 mRNA. Translation: AAH33682.1 .
CCDSi CCDS31591.1. [Q4U2R8-1 ]
CCDS44631.1. [Q4U2R8-4 ]
CCDS44632.1. [Q4U2R8-3 ]
CCDS8041.1. [Q4U2R8-2 ]
RefSeqi NP_004781.2. NM_004790.4. [Q4U2R8-1 ]
NP_695008.1. NM_153276.2. [Q4U2R8-2 ]
NP_695009.1. NM_153277.2. [Q4U2R8-3 ]
NP_695010.1. NM_153278.2. [Q4U2R8-4 ]
UniGenei Hs.369252.

3D structure databases

ProteinModelPortali Q4U2R8.
SMRi Q4U2R8. Positions 106-524.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114759. 2 interactions.
IntActi Q4U2R8. 1 interaction.
MINTi MINT-1474237.

Chemistry

BindingDBi Q4U2R8.
ChEMBLi CHEMBL1641347.
DrugBanki DB00316. Acetaminophen.
DB00819. Acetazolamide.
DB06151. Acetylcysteine.
DB00945. Acetylsalicylic acid.
DB00787. Aciclovir.
DB00718. Adefovir Dipivoxil.
DB00345. Aminohippurate.
DB01424. Aminophenazone.
DB01060. Amoxicillin.
DB01435. Antipyrine.
DB00168. Aspartame.
DB01053. Benzylpenicillin.
DB01237. Bromodiphenhydramine.
DB00887. Bumetanide.
DB01197. Captopril.
DB00578. Carbenicillin.
DB00821. Carprofen.
DB00520. Caspofungin.
DB01414. Cefacetrile.
DB01140. Cefadroxil.
DB00456. Cefalotin.
DB01326. Cefamandole.
DB01327. Cefazolin.
DB01329. Cefoperazone.
DB00493. Cefotaxime.
DB00229. Cefotiam.
DB01333. Cefradine.
DB00438. Ceftazidime.
DB01212. Ceftriaxone.
DB00567. Cephalexin.
DB00446. Chloramphenicol.
DB00880. Chlorothiazide.
DB00672. Chlorpropamide.
DB00369. Cidofovir.
DB01597. Cilastatin.
DB00501. Cimetidine.
DB00827. Cinoxacin.
DB01147. Cloxacillin.
DB00286. Conjugated Estrogens.
DB00091. Cyclosporine.
DB00606. Cyclothiazide.
DB08912. Dabrafenib.
DB00586. Diclofenac.
DB00900. Didanosine.
DB00861. Diflunisal.
DB01160. Dinoprost Tromethamine.
DB00917. Dinoprostone.
DB00254. Doxycycline.
DB00584. Enalapril.
DB00903. Ethacrynic acid.
DB00749. Etodolac.
DB00693. Fluorescein.
DB00712. Flurbiprofen.
DB00158. Folic Acid.
DB00529. Foscarnet.
DB00695. Furosemide.
DB01004. Ganciclovir.
DB00798. Gentamicin.
DB01016. Glyburide.
DB00999. Hydrochlorothiazide.
DB01050. Ibuprofen.
DB00328. Indomethacin.
DB01009. Ketoprofen.
DB00709. Lamivudine.
DB01137. Levofloxacin.
DB00678. Losartan.
DB00939. Meclofenamic acid.
DB00703. Methazolamide.
DB00563. Methotrexate.
DB01017. Minocycline.
DB00607. Nafcillin.
DB00779. Nalidixic Acid.
DB00788. Naproxen.
DB00731. Nateglinide.
DB01059. Norfloxacin.
DB01051. Novobiocin.
DB01165. Ofloxacin.
DB00595. Oxytetracycline.
DB00812. Phenylbutazone.
DB00319. Piperacillin.
DB00554. Piroxicam.
DB00175. Pravastatin.
DB01032. Probenecid.
DB00140. Riboflavin.
DB00936. Salicylic acid.
DB00649. Stavudine.
DB01082. Streptomycin.
DB00605. Sulindac.
DB00300. Tenofovir.
DB00759. Tetracycline.
DB01124. Tolbutamide.
DB00500. Tolmetin.
DB00432. Trifluridine.
DB00577. Valaciclovir.
DB00313. Valproic Acid.
DB00512. Vancomycin.
DB00943. Zalcitabine.
DB00495. Zidovudine.
GuidetoPHARMACOLOGYi 1025.

Protein family/group databases

TCDBi 2.A.1.19.31. the major facilitator superfamily (mfs).

Polymorphism databases

DMDMi 74762955.

Proteomic databases

PaxDbi Q4U2R8.
PRIDEi Q4U2R8.

Protocols and materials databases

DNASUi 9356.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360421 ; ENSP00000353597 ; ENSG00000197901 . [Q4U2R8-2 ]
ENST00000377871 ; ENSP00000367102 ; ENSG00000197901 . [Q4U2R8-1 ]
ENST00000421062 ; ENSP00000404441 ; ENSG00000197901 . [Q4U2R8-4 ]
ENST00000458333 ; ENSP00000396401 ; ENSG00000197901 . [Q4U2R8-3 ]
GeneIDi 9356.
KEGGi hsa:9356.
UCSCi uc001nwj.3. human. [Q4U2R8-2 ]
uc001nwk.3. human. [Q4U2R8-1 ]
uc001nwl.3. human. [Q4U2R8-3 ]
uc001nwm.3. human. [Q4U2R8-4 ]

Organism-specific databases

CTDi 9356.
GeneCardsi GC11M062744.
HGNCi HGNC:10970. SLC22A6.
MIMi 607582. gene.
neXtProti NX_Q4U2R8.
PharmGKBi PA388.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00760000118852.
HOVERGENi HBG108433.
InParanoidi Q4U2R8.
KOi K08203.
OMAi MIRQTGM.
OrthoDBi EOG7C8GH9.
PhylomeDBi Q4U2R8.
TreeFami TF315847.

Enzyme and pathway databases

Reactomei REACT_22310. Organic anion transport.

Miscellaneous databases

GeneWikii Organic_anion_transporter_1.
GenomeRNAii 9356.
NextBioi 35037.
PROi Q4U2R8.
SOURCEi Search...

Gene expression databases

Bgeei Q4U2R8.
ExpressionAtlasi Q4U2R8. baseline and differential.
Genevestigatori Q4U2R8.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00898. 2A0119. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a human renal p-aminohippurate transporter, hROAT1."
    Reid G., Wolff N.A., Dautzenberg F.M., Burckhardt G.
    Kidney Blood Press. Res. 21:233-237(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
  2. "Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney."
    Hosoyamada M., Sekine T., Kanai Y., Endou H.
    Am. J. Physiol. 276:F122-F128(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, FUNCTION.
    Tissue: Kidney.
  3. "Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C."
    Lu R., Chan B.S., Schuster V.L.
    Am. J. Physiol. 276:F295-F303(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Kidney.
  4. "Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)."
    Race J.E., Grassl S.M., Williams W.J., Holtzman E.J.
    Biochem. Biophys. Res. Commun. 255:508-514(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Kidney.
  5. "The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1."
    Cihlar T., Lin D.C., Pritchard J.B., Fuller M.D., Mendel D.B., Sweet D.H.
    Mol. Pharmacol. 56:570-580(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), GLYCOSYLATION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
    Tissue: Kidney.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 3 AND 4), BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
    Tissue: Kidney.
  7. NIEHS SNPs program
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-104.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon.
  11. "Interaction of cysteine conjugates with human and rabbit organic anion transporter 1."
    Groves C.E., Munoz L., Bahn A., Burckhardt G., Wright S.H.
    J. Pharmacol. Exp. Ther. 304:560-566(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
  12. "Role of glycosylation in the organic anion transporter OAT1."
    Tanaka K., Xu W., Zhou F., You G.
    J. Biol. Chem. 279:14961-14966(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ASN-39, GLYCOSYLATION AT ASN-39; ASN-56; ASN-92 AND ASN-97.
  13. "Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1."
    Hong M., Zhou F., You G.
    J. Biol. Chem. 279:31478-31482(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF LEU-30 AND THR-36.
  14. "Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)."
    Srimaroeng C., Chatsudthipong V., Aslamkhan A.G., Pritchard J.B.
    J. Pharmacol. Exp. Ther. 313:621-628(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney."
    Tahara H., Shono M., Kusuhara H., Kinoshita H., Fuse E., Takadate A., Otagiri M., Sugiyama Y.
    Pharm. Res. 22:647-660(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: BIOPHYSICOCHEMICAL PROPERTIES.
  16. "A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport."
    Perry J.L., Dembla-Rajpal N., Hall L.A., Pritchard J.B.
    J. Biol. Chem. 281:38071-38079(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF TYR-230; LYS-431 AND PHE-438, SUBSTRATE-BINDING SITES, FUNCTION.
  17. "Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate."
    Mizuno N., Takahashi T., Iwase Y., Kusuhara H., Niwa T., Sugiyama Y.
    Drug Metab. Dispos. 35:1429-1434(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  18. "Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6)."
    Bleasby K., Hall L.A., Perry J.L., Mohrenweiser H.W., Pritchard J.B.
    J. Pharmacol. Exp. Ther. 314:923-931(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HIS-50, CHARACTERIZATION OF VARIANT HIS-50.
  19. "Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]."
    Xu G., Bhatnagar V., Wen G., Hamilton B.A., Eraly S.A., Nigam S.K.
    Kidney Int. 68:1491-1499(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PRO-7 AND HIS-50.

Entry informationi

Entry nameiS22A6_HUMAN
AccessioniPrimary (citable) accession number: Q4U2R8
Secondary accession number(s): A8MY93
, B2D0R6, O95187, O95742, Q7LDA0, Q8N192, Q9NQA6, Q9NQC2, Q9UBG6, Q9UEQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3