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Protein

39S ribosomal protein L51, mitochondrial

Gene

MRPL51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L51, mitochondrial
Short name:
L51mt
Short name:
MRP-L51
Alternative name(s):
bMRP-64
Short name:
bMRP64
Gene namesi
Name:MRPL51
Synonyms:MRP64
ORF Names:CDA09, HSPC241
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14044. MRPL51.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30984.

Polymorphism and mutation databases

BioMutaiMRPL51.
DMDMi74762954.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131MitochondrionSequence analysisAdd
BLAST
Chaini32 – 1289739S ribosomal protein L51, mitochondrialPRO_0000273082Add
BLAST

Proteomic databases

EPDiQ4U2R6.
MaxQBiQ4U2R6.
PaxDbiQ4U2R6.
PeptideAtlasiQ4U2R6.
PRIDEiQ4U2R6.
TopDownProteomicsiQ4U2R6.

Expressioni

Gene expression databases

BgeeiENSG00000111639.
CleanExiHS_MRPL51.
ExpressionAtlasiQ4U2R6. baseline and differential.
GenevisibleiQ4U2R6. HS.

Organism-specific databases

HPAiHPA039923.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with OXA1L (By similarity).By similarity

Protein-protein interaction databases

BioGridi119414. 31 interactions.
IntActiQ4U2R6. 4 interactions.
MINTiMINT-6775055.
STRINGi9606.ENSP00000229238.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40i1-128[»]
3J9Melectron microscopy3.50i1-128[»]
ProteinModelPortaliQ4U2R6.
SMRiQ4U2R6. Positions 32-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4045. Eukaryota.
ENOG4111M24. LUCA.
GeneTreeiENSGT00390000018821.
HOGENOMiHOG000154145.
HOVERGENiHBG093901.
InParanoidiQ4U2R6.
KOiK17432.
OMAiFNRHGKY.
OrthoDBiEOG091G0V79.
PhylomeDBiQ4U2R6.
TreeFamiTF106130.

Family and domain databases

InterProiIPR019373. Ribosomal_L51_mit.
[Graphical view]
PfamiPF10244. MRP-L51. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4U2R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNLLSGAG RRLWDWVPLA CRSFSLGVPR LIGIRLTLPP PKVVDRWNEK
60 70 80 90 100
RAMFGVYDNI GILGNFEKHP KELIRGPIWL RGWKGNELQR CIRKRKMVGS
110 120
RMFADDLHNL NKRIRYLYKH FNRHGKFR
Length:128
Mass (Da):15,095
Last modified:July 19, 2005 - v1
Checksum:i9DB4720D5B387A5D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791W → R in AAF36161 (PubMed:11042152).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021M → I.
Corresponds to variant rs9526 [ dbSNP | Ensembl ].
VAR_030079

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049959 mRNA. Translation: BAB41012.1.
AF212248 mRNA. Translation: AAK14931.1.
AF151075 mRNA. Translation: AAF36161.1.
BC000191 mRNA. Translation: AAH00191.1.
BC014329 mRNA. Translation: AAH14329.1.
AB051355 Genomic DNA. Translation: BAB54944.1.
CCDSiCCDS8547.1.
RefSeqiNP_057581.2. NM_016497.3.
UniGeneiHs.55847.

Genome annotation databases

EnsembliENST00000229238; ENSP00000229238; ENSG00000111639.
GeneIDi51258.
KEGGihsa:51258.
UCSCiuc001qom.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049959 mRNA. Translation: BAB41012.1.
AF212248 mRNA. Translation: AAK14931.1.
AF151075 mRNA. Translation: AAF36161.1.
BC000191 mRNA. Translation: AAH00191.1.
BC014329 mRNA. Translation: AAH14329.1.
AB051355 Genomic DNA. Translation: BAB54944.1.
CCDSiCCDS8547.1.
RefSeqiNP_057581.2. NM_016497.3.
UniGeneiHs.55847.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40i1-128[»]
3J9Melectron microscopy3.50i1-128[»]
ProteinModelPortaliQ4U2R6.
SMRiQ4U2R6. Positions 32-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119414. 31 interactions.
IntActiQ4U2R6. 4 interactions.
MINTiMINT-6775055.
STRINGi9606.ENSP00000229238.

Polymorphism and mutation databases

BioMutaiMRPL51.
DMDMi74762954.

Proteomic databases

EPDiQ4U2R6.
MaxQBiQ4U2R6.
PaxDbiQ4U2R6.
PeptideAtlasiQ4U2R6.
PRIDEiQ4U2R6.
TopDownProteomicsiQ4U2R6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229238; ENSP00000229238; ENSG00000111639.
GeneIDi51258.
KEGGihsa:51258.
UCSCiuc001qom.3. human.

Organism-specific databases

CTDi51258.
GeneCardsiMRPL51.
HGNCiHGNC:14044. MRPL51.
HPAiHPA039923.
MIMi611855. gene.
neXtProtiNX_Q4U2R6.
PharmGKBiPA30984.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4045. Eukaryota.
ENOG4111M24. LUCA.
GeneTreeiENSGT00390000018821.
HOGENOMiHOG000154145.
HOVERGENiHBG093901.
InParanoidiQ4U2R6.
KOiK17432.
OMAiFNRHGKY.
OrthoDBiEOG091G0V79.
PhylomeDBiQ4U2R6.
TreeFamiTF106130.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL51. human.
GenomeRNAii51258.
PROiQ4U2R6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111639.
CleanExiHS_MRPL51.
ExpressionAtlasiQ4U2R6. baseline and differential.
GenevisibleiQ4U2R6. HS.

Family and domain databases

InterProiIPR019373. Ribosomal_L51_mit.
[Graphical view]
PfamiPF10244. MRP-L51. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRM51_HUMAN
AccessioniPrimary (citable) accession number: Q4U2R6
Secondary accession number(s): Q96Q57, Q9BQ36, Q9P0N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 19, 2005
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.