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Protein

39S ribosomal protein L51, mitochondrial

Gene

MRPL51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L51, mitochondrial
Short name:
L51mt
Short name:
MRP-L51
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL511 Publication
bMRP-64
Short name:
bMRP64
Gene namesi
Name:MRPL51
Synonyms:MRP64
ORF Names:CDA09, HSPC241
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111639.7.
HGNCiHGNC:14044. MRPL51.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111639.
PharmGKBiPA30984.

Polymorphism and mutation databases

BioMutaiMRPL51.
DMDMi74762954.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31MitochondrionSequence analysisAdd BLAST31
ChainiPRO_000027308232 – 12839S ribosomal protein L51, mitochondrialAdd BLAST97

Proteomic databases

EPDiQ4U2R6.
MaxQBiQ4U2R6.
PaxDbiQ4U2R6.
PeptideAtlasiQ4U2R6.
PRIDEiQ4U2R6.
TopDownProteomicsiQ4U2R6.

Expressioni

Gene expression databases

BgeeiENSG00000111639.
CleanExiHS_MRPL51.
ExpressionAtlasiQ4U2R6. baseline and differential.
GenevisibleiQ4U2R6. HS.

Organism-specific databases

HPAiHPA039923.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503, PubMed:25838379). Interacts with OXA1L (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi119414. 36 interactors.
CORUMiQ4U2R6.
IntActiQ4U2R6. 5 interactors.
MINTiMINT-6775055.
STRINGi9606.ENSP00000229238.

Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi49 – 52Combined sources4
Turni53 – 55Combined sources3
Beta strandi56 – 59Combined sources4
Turni62 – 66Combined sources5
Helixi70 – 72Combined sources3
Helixi78 – 80Combined sources3
Helixi87 – 97Combined sources11
Helixi99 – 101Combined sources3
Helixi104 – 122Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40i1-128[»]
3J9Melectron microscopy3.50i1-128[»]
5OOLelectron microscopy3.06i1-128[»]
5OOMelectron microscopy3.03i1-128[»]
ProteinModelPortaliQ4U2R6.
SMRiQ4U2R6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4045. Eukaryota.
ENOG4111M24. LUCA.
GeneTreeiENSGT00390000018821.
HOGENOMiHOG000154145.
HOVERGENiHBG093901.
InParanoidiQ4U2R6.
KOiK17432.
OMAiFNRHGKY.
OrthoDBiEOG091G0V79.
PhylomeDBiQ4U2R6.
TreeFamiTF106130.

Family and domain databases

InterProiView protein in InterPro
IPR019373. Ribosomal_L51_mit.
PANTHERiPTHR13409. PTHR13409. 1 hit.
PfamiView protein in Pfam
PF10244. MRP-L51. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4U2R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNLLSGAG RRLWDWVPLA CRSFSLGVPR LIGIRLTLPP PKVVDRWNEK
60 70 80 90 100
RAMFGVYDNI GILGNFEKHP KELIRGPIWL RGWKGNELQR CIRKRKMVGS
110 120
RMFADDLHNL NKRIRYLYKH FNRHGKFR
Length:128
Mass (Da):15,095
Last modified:July 19, 2005 - v1
Checksum:i9DB4720D5B387A5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79W → R in AAF36161 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030079102M → I. Corresponds to variant dbSNP:rs9526Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049959 mRNA. Translation: BAB41012.1.
AF212248 mRNA. Translation: AAK14931.1.
AF151075 mRNA. Translation: AAF36161.1.
BC000191 mRNA. Translation: AAH00191.1.
BC014329 mRNA. Translation: AAH14329.1.
AB051355 Genomic DNA. Translation: BAB54944.1.
CCDSiCCDS8547.1.
RefSeqiNP_057581.2. NM_016497.3.
UniGeneiHs.55847.

Genome annotation databases

EnsembliENST00000229238; ENSP00000229238; ENSG00000111639.
GeneIDi51258.
KEGGihsa:51258.
UCSCiuc001qom.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRM51_HUMAN
AccessioniPrimary (citable) accession number: Q4U2R6
Secondary accession number(s): Q96Q57, Q9BQ36, Q9P0N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 19, 2005
Last modified: October 25, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families