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Q4U2R1

- HERC2_MOUSE

UniProt

Q4U2R1 - HERC2_MOUSE

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Protein
E3 ubiquitin-protein ligase HERC2
Gene
Herc2, Jdf2, Kiaa0393, Rjs
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei4764 – 47641Glycyl thioester intermediate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri2703 – 275048ZZ-type
Add
BLAST

GO - Molecular functioni

  1. SUMO binding Source: UniProtKB
  2. heme binding Source: InterPro
  3. ligase activity Source: UniProtKB-KW
  4. ubiquitin-protein transferase activity Source: UniProtKB
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA repair Source: UniProtKB
  2. cellular response to DNA damage stimulus Source: UniProtKB
  3. protein ubiquitination Source: UniProtKB
  4. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: RefGenome
  5. spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

DNA damage, DNA repair, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase HERC2 (EC:6.3.2.-)
Alternative name(s):
HECT domain and RCC1-like domain-containing protein 2
Gene namesi
Name:Herc2
Synonyms:Jdf2, Kiaa0393, Rjs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:103234. Herc2.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity. Nucleus By similarity
Note: Recruited to sites of DNA damage in response to ionising radiation (IR) via its interaction with RNF8 By similarity. May loose association with centrosomes during mitosis By similarity.

GO - Cellular componenti

  1. centriole Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB
  3. mitochondrial inner membrane Source: MGI
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Herc2 are the cause of the runty, jerky, sterile phenotype (rjs), also known as the juvenile development and fertility phenotype (jfd2), which is characterized by reduced size, jerky gait, fertility problems including spermatocyte and oocyte abnormalities, defective maternal behavior and reduced lifespan with juvenile lethality.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 48364836E3 ubiquitin-protein ligase HERC2
PRO_0000229740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei648 – 6481Phosphothreonine By similarity
Modified residuei1578 – 15781Phosphoserine1 Publication
Modified residuei1945 – 19451Phosphothreonine By similarity
Modified residuei2455 – 24551Phosphoserine By similarity
Modified residuei2929 – 29291Phosphoserine By similarity
Modified residuei4812 – 48121Phosphoserine By similarity
Modified residuei4813 – 48131Phosphoserine By similarity
Modified residuei4816 – 48161Phosphoserine By similarity
Modified residuei4829 – 48291Phosphothreonine By similarity

Post-translational modificationi

Phosphorylation at Thr-4829 is required for interaction with RNF8.
Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs), promoting the interaction with RNF8 By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ4U2R1.
PaxDbiQ4U2R1.
PRIDEiQ4U2R1.

PTM databases

PhosphoSiteiQ4U2R1.

Expressioni

Tissue specificityi

Highest levels are found in brain and testis with lower levels in heart, lung, liver, skeletal muscle and kidney. Little expression detected in spleen.1 Publication

Gene expression databases

BgeeiQ4U2R1.
GenevestigatoriQ4U2R1.

Interactioni

Subunit structurei

Interacts (when phosphorylated at Thr-4829 and sumoylated) with RNF8 (via FHA domain); this interaction increases after ionising radiation (IR) treatment. Interacts with XPA By similarity. Interacts with NEURL4. Via its interaction with NEURL4, may indirectly interact with CCP110 and CEP97 By similarity.

Protein-protein interaction databases

BioGridi200274. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ4U2R1.
SMRiQ4U2R1. Positions 423-780, 1206-1297, 1868-1929, 3955-4320.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati416 – 46247RCC1 1-1
Add
BLAST
Repeati463 – 51351RCC1 1-2
Add
BLAST
Repeati514 – 56956RCC1 1-3
Add
BLAST
Repeati570 – 62152RCC1 1-4
Add
BLAST
Repeati624 – 67552RCC1 1-5
Add
BLAST
Repeati676 – 72752RCC1 1-6
Add
BLAST
Repeati729 – 77951RCC1 1-7
Add
BLAST
Domaini1208 – 128477Cytochrome b5 heme-binding
Add
BLAST
Domaini1860 – 193374MIB/HERC2
Add
BLAST
Domaini2760 – 2937178DOC
Add
BLAST
Repeati2959 – 301052RCC1 2-1
Add
BLAST
Repeati3011 – 306555RCC1 2-2
Add
BLAST
Repeati3066 – 311752RCC1 2-3
Add
BLAST
Repeati3119 – 316951RCC1 2-4
Add
BLAST
Repeati3172 – 322352RCC1 2-5
Add
BLAST
Repeati3225 – 327551RCC1 2-6
Add
BLAST
Repeati3276 – 332752RCC1 2-7
Add
BLAST
Repeati3953 – 400452RCC1 3-1
Add
BLAST
Repeati4006 – 405853RCC1 3-2
Add
BLAST
Repeati4060 – 411051RCC1 3-3
Add
BLAST
Repeati4112 – 416453RCC1 3-4
Add
BLAST
Repeati4166 – 421651RCC1 3-5
Add
BLAST
Repeati4218 – 426851RCC1 3-6
Add
BLAST
Repeati4270 – 432051RCC1 3-7
Add
BLAST
Domaini4459 – 4796338HECT
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili948 – 98134 Reviewed prediction
Add
BLAST

Domaini

The ZZ-type zinc finger mediates binding to SUMO1, and at lowe level SUMO2 By similarity.
The RCC1 repeats are grouped into three seven-bladed beta-propeller regions By similarity.

Sequence similaritiesi

Contains 1 DOC domain.
Contains 1 MIB/HERC2 domain.
Contains 21 RCC1 repeats.

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5021.
GeneTreeiENSGT00750000117470.
HOVERGENiHBG081598.
InParanoidiQ4U2R1.
KOiK10595.
OMAiGHGTDVH.
OrthoDBiEOG70KGNN.
TreeFamiTF320636.

Family and domain databases

Gene3Di2.130.10.30. 3 hits.
2.30.30.30. 1 hit.
2.60.120.260. 1 hit.
3.10.120.10. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR006624. Beta-propeller_rpt_TECPR.
IPR021097. CPH_domain.
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR008979. Galactose-bd-like.
IPR000569. HECT.
IPR010606. Mib_Herc2.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR014722. Rib_L2_dom2.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF03256. APC10. 1 hit.
PF11515. Cul7. 1 hit.
PF00173. Cyt-b5. 1 hit.
PF00632. HECT. 1 hit.
PF06701. MIB_HERC2. 1 hit.
PF00415. RCC1. 18 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00119. HECTc. 1 hit.
SM00706. TECPR. 4 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 3 hits.
SSF55856. SSF55856. 1 hit.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50255. CYTOCHROME_B5_2. 1 hit.
PS51284. DOC. 1 hit.
PS50237. HECT. 1 hit.
PS51416. MIB_HERC2. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 19 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 12 Publications (identifier: Q4U2R1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MPSESFCLAA QSRLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIVYTGT     50
ELAQNRELPL RKDDGVDAQS GTKKEDLNDK EKKEEEETPA PVYRAKSILE 100
SWVWGRQPDV NELKECLSVL VKEQQALAVQ SATTTLSALR LKQRLVILER 150
YFIALNRTVF QENVKVKWKS SSISVPPTEK KSARPTGRGV EGLARVGSRA 200
ALSFAFAFLR RAWRSGEDAD LCSELLQESL DALRALPEAS LFDESTVSSV 250
WLEVVERATR FLRSVVTGDV HGTPGTKGPG GVPLQDQHLA LAILLELAVQ 300
RGTLSQMLSA ILLLLQLWDS GAQETDNERS AQGTSAPLLP LLQRFQSIIC 350
SKDVPHTESD MHLLSGPLSP NESFLRYLTL PQDNELAIDL RQTAVVVMAH 400
LDRLATPCMP PLCSSPTSHK GSLQEVIGWG LIGWKYYANV IGPIQCEGLA 450
SLGVMQVACA EKRFLILSRN GRVYTQAYNS DMLAPQLVQG LASRNIVKIA 500
AHSDGHHYLA LAATGEVYSW GCGDGGRLGH GDTVPLEEPK VISAFSGKQA 550
GKHVVHIACG STYSAAITAE GELYTWGRGN YGRLGHGSSE DEAIPMLVAG 600
LKGLKVIDVA CGSGDAQTLA VTENGQVWSW GDGDYGKLGR GGSDGCKTPK 650
LIEKLQDLDV IKVRCGSQFS IALTKDGQVY SWGKGDNQRL GHGTEEHVRY 700
PKLLEGLQGK KVIDVAAGST HCLALTEDSE VHSWGSNDQC QHFDTLRVTK 750
PEPTALPGLD SKHIVGIACG PAQSFAWSSC SEWSIGLRVP FVVDICSMTF 800
EQLDLLLRQV SEGMDGTADW PPPQEKECMA VATLNLLRLQ LHAAISHQVD 850
PEFLGLGLGS VLLNSLKQTV VTLASSAGVL STVQSAAQAV LQSGWSVLLP 900
TAEERARALS ALLPCTVSGN EVNISPGRRF MIDLLVGSLM ADGGLESALN 950
AAITAEIQDI EAKKEAQKEK EIDEQEASAS TFHRSRTPLD KDLINTGIYE 1000
SSGKQCLPLV QLIQQLLRNI ASQTVARLKD VARRISSCLD FEQQSCERSA 1050
SLDLLLRFQR LLISKLYPGE KIGPISDTSS PELMGVGSLL KKYTALVCTH 1100
IGDILPVAAS IASSSWQHFA EVACVMEGDF TGVLLPELVV SIVLLLSKNA 1150
SLMQEAGAIP LLGGLLEHLD RFNHLAPGKE RDDHEELAWP GIMESFFTGQ 1200
NCRNNEEVTL IRKADLENHN KDGGFWTVID GKVYGIKDFQ TQSLTGNSIL 1250
AQFAGEDPVV ALEAALQFED TQESMHAFCV GQYLEPDQEV VTIPDLGSLS 1300
SPLIDTERNL GLLLGLHASY LAMSTPLSPV EVECAKWLQS SIFSGGLQTS 1350
QIHYSYNEEK DEDHCSSPGG TPISKSRLCS HRWALGDHSQ AFLQAIADNN 1400
IQDYNVKDFL CQIERYCRQC HLTTPITFPP EHPVEEVGRL LLCCLLKHED 1450
LGHVALSLVH VGTLGIEQVK HRTLPKSVVD VCRVVYQAKC SLIKTHQEQG 1500
RSYKEVCAPV IERLRFLFNE LRPAVCSDLS IMSKFKLLGS LPRWRRIAQK 1550
IIRERRKKRV PKKPESIDSE EKIGNEESDL EEACVLPHSP INVDKRPISM 1600
KSPKDKWQPL LNTVTGVHKY KWLKQNVQGL YPQSALLNTI VEFALKEEPV 1650
DVEKMRKCLL KQLERAEVRL EGIDTILKLA AKSFLLPSVQ YAMFCGWQRL 1700
IPEGIDIGEP LTDCLRDVDL IPPFNRMLLE VTFGKLYAWA VQNIRSVLMD 1750
ASARFKELGI QPVPLQTITN ENPAGPSLGT IPQARFLLVM LSMLTLQHGA 1800
NNLDLLLNSG TLALTQTALR LIGPTCDSVE DDMNASARGA SATVLEETRK 1850
ETAPVQLPVS GPELAAMMKI GTRVMRGVDW KWGDQDGPPP GLGRVIGELG 1900
EDGWIRVQWD TGSTNSYRMG KEGKYDLKLV ELPVSSQPSA EDSDTEDDSE 1950
AEQGERNIHP TAMMLTSVIN LLQTLCLSVG VHADIMQSEA TKTLCGLLRM 2000
LVESGTTDKP APPDRLVARE QHRSWCTLGF VRSIALTPQA CGALSSPRWI 2050
TLLMKVVEGH APFTAASLQR QILAVHLLQA VLPSWDKTER ARDMKCLVEK 2100
LFGFLGSLLT TCSSDVPLLR ESTLRKRRAR PQASLTATHS STLAEEVVGL 2150
LRTLHSLTQW NGLINKYINS QLCSVTQSYA GKTSERAQLE DYFPDSENLE 2200
VGGLMAVLAV IGGIDGRLRL GGQVMHDEFG EGTVTRITPK GRITVQFCDM 2250
RMCRVCPLNQ LKPLPAVAFS VNNLPFTEPM LSVWAELVNL AGSKLEKHKT 2300
KKSAKPAFAG QVDLDLLRSQ QLKLYILKAG RALLSHQDKL RQILSQPAVQ 2350
GTGTLQTDDG AAASPDLGDM SPEGPQPPMI LLQQLLSSAT QPSPVKAIFD 2400
KQELEAAALA LCQCLAVEST HPSSPGCEDC SSSEATTPVS VQHIHLARAK 2450
KRRQSPAPAL PIVVQLMEMG FPRKNIEFAL KSLTGTSGNA SGLPGVEALV 2500
GWLLDHSDVQ VTEFSDAETL SDEYSDEEVV EDVDDTPYPV AAGAVVTESQ 2550
TYKKRADFLS NDDYAVYVRE NVQVGMMVRC CRTYEEVCEG DVGKVIKLDR 2600
DGLHDLNVQC DWQQKGGTYW VRYIHVELIG YPPPSSSSHI KIGDKVRVKA 2650
SVTTPKYKWG SVTHQSVGLV KAFSANGKDI IVDFPQQSHW TGLLSEMELV 2700
PSIHPGVTCD GCQTFPINGS RFKCRNCDDF DFCETCFKTK KHNTRHTFGR 2750
INEPGQSAVF CGRSGKQLKR CHSSQPGMLL DSWSRMVKSL NVSSSVNQAS 2800
RLIDGSEPCW QSSGSQGKHW IRLEIFPDVL VHRLKMIVDP ADSSYMPSLV 2850
VVSGGNSLNN LIELKTININ QTDTTVPLLS DCAEYHRYIE IAIKQCRSSG 2900
IDCKIHGLIL LGRIRAEEED LAAVPFLASD NEEEEDDKGS TGSLIRKKTP 2950
GLESTATIRT KVFVWGLNDK DQLGGLKGSK IKVPSFSETL SALNVVQVAG 3000
GSKSLFAVTV EGKVYSCGEA TNGRLGLGMS SGTVPIPRQI TALSSYVVKK 3050
VAVHSGGRHA TALTVDGKVF SWGEGDDGKL GHFSRMNCDK PRLIEALKTK 3100
RIRDIACGSS HSAALTSSGE LYTWGLGEYG RLGHGDNTTQ LKPKMVKVLL 3150
GHRVIQVACG SRDAQTLALT DEGLVFSWGD GDFGKLGRGG SEGCNIPQNI 3200
ERLNGQGVCQ IECGAQFSLA LTKSGVVWTW GKGDYFRLGH GSDVHVRKPQ 3250
VVEGLRGKKI VHVAVGALHC LAVTDSGQVY AWGDNDHGQQ GNGTTTVNRK 3300
PTLVQGLEGQ KITRVACGSS HSVAWTTVDV ATPSVHEPVL FQTARDPLGA 3350
SYLGVPSDAD SSSSSNKISG ANNCKPNRPS LAKILLSLEG NLAKQQALSH 3400
ILTALQIMYA RDAVVGALMP AGMLAPVECP SFSSSAPASD VSAMASPMHM 3450
EDSTLAADLE DRLSPNLWQE KREIVSSEDA VTPSAVTPSA PSASSRPFIP 3500
VTDDPGAASI IAETMTKTKE DVESQNKTSG PEPQSLDEFT SLLIPDDTRV 3550
VVELLKLSVC SRAGDKGREV LSAVLSGMGT AYPQVADMLL ELCVTELEDV 3600
ATDSQSGRLS SQPVVVESSH PYTDDTSTSG TVKIPGAEGL RVEFDRQCST 3650
ERRHDPLTVM DGVNRIVSVR SGREWSDWSS ELRIPGDELK WKFISDGSVN 3700
GWGWRFTVYP IMPAAGPKDL LSDRCVLSCP SMDLVTCLLD FRLNLTSNRS 3750
IVPRLAASLA ACAQLSALAA SHRMWALQRL RRLLTTEFGQ SININRLLGE 3800
NDGESRALSF TGSALAALVK GLPEALQRQF EYEDPIVRGG KQLLHSPFFK 3850
VLVALACDLE LDTLPCCAET HKWAWFRRYC MASRVAVALD KRTPLPRLFL 3900
DEVAKKIREL MADSESMDVL HESHSIFKRE QDEQLVQWMN RRPDDWTLSA 3950
GGSGTIYGWG HNHRGQLGGI EGAKVKVPTP CEALATLRPV QLIGGEQTLF 4000
AVTADGKLYA TGYGAGGRLG IGGTESVSTP TLLESIQHVF IKKVAVNSGG 4050
KHCLALSSEG EVYSWGEAED GKLGHGNRSP CDRPRVIESL RGIEVVDVAA 4100
GGAHSACVTA AGDLYTWGKG RYGRLGHSDS EDQLKPKLVE ALQGHRVIDI 4150
ACGSGDAQTL CLTDDDTVWS WGDGDYGKLG RGGSDGCKVP MKIDSLTGLG 4200
VVKVECGSQF SVALTKSGAV YTWGKGDYHR LGHGSDDHVR RPRQVQGLQG 4250
KKVIAIATGS LHCVCCTEDG EVYTWGDNDE GQLGDGTTNA IQRPRLVAAL 4300
QGKKVNRVAC GSAHTLAWST SKPASAGKLP AQVPMEYNHL QEIPIIALRN 4350
RLLLLHHISE LFCPCIPMFD LEGSLDETGL GPSVGFDTLR GILISQGKEA 4400
AFRKVVQATM VRDRQHGPVV ELNRIQVKRS RSKGGLAGPD GTKSVFGQMC 4450
AKMSSFSPDS LLLPHRVWKV KFVGESVDDC GGGYSESIAE ICEELQNGLT 4500
PLLIVTPNGR DESGANRDCY LLNPATRAPV HCSMFRFLGV LLGIAIRTGS 4550
PLSLNLAEPV WKQLAGMSLT IADLSEVDKD FIPGLMYIRD NEATSEEFEA 4600
MSLPFTVPSA SGQDIQLSSK HTHITLDNRA EYVRLAINYR LHEFDEQVAA 4650
VREGMARVVP VPLLSLFTGY ELETMVCGSP DIPLHLLKSV ATYKGIEPSA 4700
SLVQWFWEVM ESFSNTERSL FLRFVWGRTR LPRTIADFRG RDFVIQVLDK 4750
YNPPDHFLPE SYTCFFLLKL PRYSCKQVLE EKLKYAIHFC KSIDTDDYAR 4800
IALTGEPAAD DSSEDSDNED ADSFASDSTQ DYLTGH 4836
Length:4,836
Mass (Da):527,456
Last modified:July 27, 2011 - v3
Checksum:i481BC90E231C93D8
GO
Isoform 21 Publication (identifier: Q4U2R1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3637-3672: Missing.

Note: No experimental confirmation available.

Show »
Length:4,800
Mass (Da):523,388
Checksum:i3E3BA1D6DE63BAF7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3637 – 367236Missing in isoform 2. 1 Publication
VSP_051975Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti692 – 6921H → L in AAC31431. 1 Publication
Sequence conflicti724 – 7241A → V in AAD08658. 1 Publication
Sequence conflicti747 – 7471R → G in AAD08658. 1 Publication
Sequence conflicti756 – 7561L → F in AAD08658. 1 Publication
Sequence conflicti929 – 9291R → P in AAD08658. 1 Publication
Sequence conflicti1114 – 11141S → N in AAD08658. 1 Publication
Sequence conflicti1235 – 12351G → D in AAD08658. 1 Publication
Sequence conflicti2348 – 23481A → P in AAC31431. 1 Publication
Sequence conflicti2470 – 24701G → S in BAE36828. 1 Publication
Sequence conflicti2523 – 25231E → D in AAC31431. 1 Publication
Sequence conflicti2567 – 25671Y → F in AAC31431. 1 Publication
Sequence conflicti2572 – 25721V → L in AAC31431. 1 Publication
Sequence conflicti3095 – 30951E → Q in AAD08658. 1 Publication
Sequence conflicti3107 – 31071C → Y in AAD08658. 1 Publication
Sequence conflicti3114 – 31141A → P in AAD08658. 1 Publication
Sequence conflicti3161 – 31611S → T in AAC31431. 1 Publication
Sequence conflicti3385 – 33862LL → VV in AAD08658. 1 Publication
Sequence conflicti3508 – 35081A → V in AAD08658. 1 Publication
Sequence conflicti4069 – 40691E → K in BAD90404. 1 Publication
Sequence conflicti4187 – 41871C → S in AAC31431. 1 Publication
Sequence conflicti4604 – 46041P → S in BAE36593. 1 Publication
Sequence conflicti4716 – 47161T → A in AAC31431. 1 Publication
Sequence conflicti4723 – 47231R → C in AAD08658. 1 Publication
Sequence conflicti4730 – 47301R → S in AAC31431. 1 Publication
Sequence conflicti4752 – 47521N → Y in AAC31431. 1 Publication
Sequence conflicti4790 – 47901C → S in AAC31431. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF061529 mRNA. Translation: AAC31431.1.
AF071173 mRNA. Translation: AAD08658.1.
AC102121 Genomic DNA. No translation available.
AC102150 Genomic DNA. No translation available.
AK141515 mRNA. Translation: BAE24711.1.
AK148361 mRNA. Translation: BAE28504.1.
AK161826 mRNA. Translation: BAE36593.1.
AK162270 mRNA. Translation: BAE36828.1.
AK162708 mRNA. Translation: BAE37031.1.
AK220338 mRNA. Translation: BAD90404.1.
BC044667 mRNA. Translation: AAH44667.1.
BC054829 mRNA. Translation: AAH54829.1.
CCDSiCCDS21318.1. [Q4U2R1-1]
RefSeqiNP_034548.2. NM_010418.2. [Q4U2R1-1]
XP_006540700.1. XM_006540637.1. [Q4U2R1-1]
XP_006540701.1. XM_006540638.1. [Q4U2R1-1]
XP_006540702.1. XM_006540639.1. [Q4U2R1-2]
UniGeneiMm.20929.

Genome annotation databases

EnsembliENSMUST00000076226; ENSMUSP00000075579; ENSMUSG00000030451. [Q4U2R1-1]
ENSMUST00000164095; ENSMUSP00000131573; ENSMUSG00000030451. [Q4U2R1-1]
GeneIDi15204.
KEGGimmu:15204.
UCSCiuc009hdv.1. mouse. [Q4U2R1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF061529 mRNA. Translation: AAC31431.1 .
AF071173 mRNA. Translation: AAD08658.1 .
AC102121 Genomic DNA. No translation available.
AC102150 Genomic DNA. No translation available.
AK141515 mRNA. Translation: BAE24711.1 .
AK148361 mRNA. Translation: BAE28504.1 .
AK161826 mRNA. Translation: BAE36593.1 .
AK162270 mRNA. Translation: BAE36828.1 .
AK162708 mRNA. Translation: BAE37031.1 .
AK220338 mRNA. Translation: BAD90404.1 .
BC044667 mRNA. Translation: AAH44667.1 .
BC054829 mRNA. Translation: AAH54829.1 .
CCDSi CCDS21318.1. [Q4U2R1-1 ]
RefSeqi NP_034548.2. NM_010418.2. [Q4U2R1-1 ]
XP_006540700.1. XM_006540637.1. [Q4U2R1-1 ]
XP_006540701.1. XM_006540638.1. [Q4U2R1-1 ]
XP_006540702.1. XM_006540639.1. [Q4U2R1-2 ]
UniGenei Mm.20929.

3D structure databases

ProteinModelPortali Q4U2R1.
SMRi Q4U2R1. Positions 423-780, 1206-1297, 1868-1929, 3955-4320.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200274. 3 interactions.

PTM databases

PhosphoSitei Q4U2R1.

Proteomic databases

MaxQBi Q4U2R1.
PaxDbi Q4U2R1.
PRIDEi Q4U2R1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000076226 ; ENSMUSP00000075579 ; ENSMUSG00000030451 . [Q4U2R1-1 ]
ENSMUST00000164095 ; ENSMUSP00000131573 ; ENSMUSG00000030451 . [Q4U2R1-1 ]
GeneIDi 15204.
KEGGi mmu:15204.
UCSCi uc009hdv.1. mouse. [Q4U2R1-1 ]

Organism-specific databases

CTDi 8924.
MGIi MGI:103234. Herc2.
Rougei Search...

Phylogenomic databases

eggNOGi COG5021.
GeneTreei ENSGT00750000117470.
HOVERGENi HBG081598.
InParanoidi Q4U2R1.
KOi K10595.
OMAi GHGTDVH.
OrthoDBi EOG70KGNN.
TreeFami TF320636.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSi HERC2. mouse.
NextBioi 287753.
PROi Q4U2R1.
SOURCEi Search...

Gene expression databases

Bgeei Q4U2R1.
Genevestigatori Q4U2R1.

Family and domain databases

Gene3Di 2.130.10.30. 3 hits.
2.30.30.30. 1 hit.
2.60.120.260. 1 hit.
3.10.120.10. 1 hit.
InterProi IPR004939. APC_su10/DOC_dom.
IPR006624. Beta-propeller_rpt_TECPR.
IPR021097. CPH_domain.
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR008979. Galactose-bd-like.
IPR000569. HECT.
IPR010606. Mib_Herc2.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR014722. Rib_L2_dom2.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF03256. APC10. 1 hit.
PF11515. Cul7. 1 hit.
PF00173. Cyt-b5. 1 hit.
PF00632. HECT. 1 hit.
PF06701. MIB_HERC2. 1 hit.
PF00415. RCC1. 18 hits.
PF00569. ZZ. 1 hit.
[Graphical view ]
PRINTSi PR00633. RCCNDNSATION.
SMARTi SM00119. HECTc. 1 hit.
SM00706. TECPR. 4 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 3 hits.
SSF55856. SSF55856. 1 hit.
SSF56204. SSF56204. 1 hit.
PROSITEi PS50255. CYTOCHROME_B5_2. 1 hit.
PS51284. DOC. 1 hit.
PS50237. HECT. 1 hit.
PS51416. MIB_HERC2. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 19 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DISEASE.
    Strain: C57BL/6.
  2. "The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities."
    Ji Y., Walkowicz M.J., Buiting K., Johnson D.K., Tarvin R.E., Rinchik E.M., Horsthemke B., Stubbs L., Nicholls R.D.
    Hum. Mol. Genet. 8:533-542(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DISEASE.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 953-1553; 1845-2470 AND 4123-4836.
    Strain: C57BL/6J.
    Tissue: Spinal cord, Testis and Vagina.
  5. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2966-4836 (ISOFORM 1).
    Tissue: Brain.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3618-4836 (ISOFORM 2).
    Strain: C57BL/6 and Czech II.
    Tissue: Mammary gland and Olfactory epithelium.
  7. "Molecular characterization of radiation- and chemically induced mutations associated with neuromuscular tremors, runting, juvenile lethality, and sperm defects in jdf2 mice."
    Walkowicz M., Ji Y., Ren X., Horsthemke B., Russell L.B., Johnson D., Rinchik E.M., Nicholls R.D., Stubbs L.
    Mamm. Genome 10:870-878(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISEASE.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1578, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiHERC2_MOUSE
AccessioniPrimary (citable) accession number: Q4U2R1
Secondary accession number(s): E9PZT6
, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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