Q4U2R1 (HERC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
E3 ubiquitin-protein ligase HERC2
EC=6.3.2.-

Alternative name(s):
HECT domain and RCC1-like domain-containing protein 2

Gene names

Name:	Herc2
Synonyms:	Jdf2, Kiaa0393, Rjs

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	4836 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity By similarity.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts (when phosphorylated at Thr-4829 and sumoylated) with RNF8 (via FHA domain); this interaction increases after ionising radiation (IR) treatment. Interacts with XPA By similarity. Interacts with NEURL4. Via its interaction with NEURL4, may indirectly interact with CCP110 and CEP97 By similarity.
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton › centrosome › centriole By similarity. Nucleus By similarity. Note: Recruited to sites of DNA damage in response to ionising radiation (IR) via its interaction with RNF8 By similarity. May loose association with centrosomes during mitosis By similarity.
Tissue specificity	Highest levels are found in brain and testis with lower levels in heart, lung, liver, skeletal muscle and kidney. Little expression detected in spleen. Ref.1
Domain	The ZZ-type zinc finger mediates binding to SUMO1, and at lowe level SUMO2 By similarity.
Post-translational modification	Phosphorylation at Thr-4829 is required for interaction with RNF8. Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs), promoting the interaction with RNF8 By similarity.
Involvement in disease	Defects in Herc2 are the cause of the runty, jerky, sterile phenotype (rjs), also known as the juvenile development and fertility phenotype (jfd2), which is characterized by reduced size, jerky gait, fertility problems including spermatocyte and oocyte abnormalities, defective maternal behavior and reduced lifespan with juvenile lethality. Ref.1 Ref.2 Ref.7
Sequence similarities	Contains 1 cytochrome b5 heme-binding domain. Contains 1 DOC domain. Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 1 MIB/HERC2 domain. Contains 19 RCC1 repeats. Contains 7 WD repeats. Contains 1 ZZ-type zinc finger.

Ontologies

Keywords
Biological process	DNA damage DNA repair Ubl conjugation pathway
Cellular component	Cytoplasm Cytoskeleton Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat WD repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Ligase
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from sequence or structural similarity. Source: UniProtKB protein ubiquitination involved in ubiquitin-dependent protein catabolic process Inferred from Biological aspect of Ancestor. Source: RefGenome spermatogenesis Inferred from mutant phenotype PubMed 5565073. Source: MGI
Cellular_component	centriole Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membrane Inferred from direct assay PubMed 12865426. Source: MGI nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	SUMO binding Inferred from sequence or structural similarity. Source: UniProtKB heme binding Inferred from electronic annotation. Source: InterPro ubiquitin-protein ligase activity Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 Ref.2 (identifier: Q4U2R1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.6 (identifier: Q4U2R1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     3637-3672: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4836	4836	E3 ubiquitin-protein ligase HERC2		PRO_0000229740
Regions
	Repeat	3 – 46	44	WD 1
	Repeat	287 – 328	42	WD 2
	Repeat	491 – 530	40	WD 3
	Repeat	514 – 569	56	RCC1 1
	Repeat	570 – 621	52	RCC1 2
	Repeat	624 – 675	52	RCC1 3
	Repeat	676 – 727	52	RCC1 4
	Repeat	705 – 744	40	WD 4
	Repeat	729 – 779	51	RCC1 5
	Domain	1208 – 1284	77	Cytochrome b5 heme-binding
	Domain	1860 – 1933	74	MIB/HERC2
	Domain	2760 – 2937	178	DOC
	Repeat	2959 – 3010	52	RCC1 6
	Repeat	3011 – 3065	55	RCC1 7
	Repeat	3066 – 3117	52	RCC1 8
	Repeat	3097 – 3134	38	WD 5
	Repeat	3118 – 3169	52	RCC1 9
	Repeat	3172 – 3223	52	RCC1 10
	Repeat	3225 – 3275	51	RCC1 11
	Repeat	3276 – 3327	52	RCC1 12
	Repeat	3928 – 3969	42	WD 6
	Repeat	3953 – 4004	52	RCC1 13
	Repeat	4006 – 4058	53	RCC1 14
	Repeat	4060 – 4110	51	RCC1 15
	Repeat	4112 – 4164	53	RCC1 16
	Repeat	4166 – 4216	51	RCC1 17
	Repeat	4218 – 4268	51	RCC1 18
	Repeat	4243 – 4285	43	WD 7
	Repeat	4270 – 4320	51	RCC1 19
	Domain	4459 – 4796	338	HECT
	Zinc finger	2703 – 2750	48	ZZ-type
	Coiled coil	948 – 981	34	Potential
Sites
	Active site	4764	1	Glycyl thioester intermediate By similarity
Amino acid modifications
	Modified residue	648	1	Phosphothreonine By similarity
	Modified residue	1945	1	Phosphothreonine By similarity
	Modified residue	2455	1	Phosphoserine By similarity
	Modified residue	2929	1	Phosphoserine Ref.8
	Modified residue	4812	1	Phosphoserine By similarity
	Modified residue	4813	1	Phosphoserine By similarity
	Modified residue	4816	1	Phosphoserine By similarity
	Modified residue	4829	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	3637 – 3672	36	Missing in isoform 2. Ref.6		VSP_051975
Experimental info
	Sequence conflict	692	1	H → L in AAC31431. Ref.1
	Sequence conflict	724	1	A → V in AAD08658. Ref.2
	Sequence conflict	747	1	R → G in AAD08658. Ref.2
	Sequence conflict	756	1	L → F in AAD08658. Ref.2
	Sequence conflict	929	1	R → P in AAD08658. Ref.2
	Sequence conflict	1114	1	S → N in AAD08658. Ref.2
	Sequence conflict	1235	1	G → D in AAD08658. Ref.2
	Sequence conflict	2348	1	A → P in AAC31431. Ref.1
	Sequence conflict	2470	1	G → S in BAE36828. Ref.4
	Sequence conflict	2523	1	E → D in AAC31431. Ref.1
	Sequence conflict	2567	1	Y → F in AAC31431. Ref.1
	Sequence conflict	2572	1	V → L in AAC31431. Ref.1
	Sequence conflict	3095	1	E → Q in AAD08658. Ref.2
	Sequence conflict	3107	1	C → Y in AAD08658. Ref.2
	Sequence conflict	3114	1	A → P in AAD08658. Ref.2
	Sequence conflict	3161	1	S → T in AAC31431. Ref.1
	Sequence conflict	3385 – 3386	2	LL → VV in AAD08658. Ref.2
	Sequence conflict	3508	1	A → V in AAD08658. Ref.2
	Sequence conflict	4069	1	E → K in BAD90404. Ref.5
	Sequence conflict	4187	1	C → S in AAC31431. Ref.1
	Sequence conflict	4604	1	P → S in BAE36593. Ref.4
	Sequence conflict	4716	1	T → A in AAC31431. Ref.1
	Sequence conflict	4723	1	R → C in AAD08658. Ref.2
	Sequence conflict	4730	1	R → S in AAC31431. Ref.1
	Sequence conflict	4752	1	N → Y in AAC31431. Ref.1
	Sequence conflict	4790	1	C → S in AAC31431. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 27, 2011. Version 3. Checksum: 481BC90E231C93D8	FASTA	4,836	527,456
	10 20 30 40 50 60 MPSESFCLAA QSRLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIVYTGT ELAQNRELPL 70 80 90 100 110 120 RKDDGVDAQS GTKKEDLNDK EKKEEEETPA PVYRAKSILE SWVWGRQPDV NELKECLSVL 130 140 150 160 170 180 VKEQQALAVQ SATTTLSALR LKQRLVILER YFIALNRTVF QENVKVKWKS SSISVPPTEK 190 200 210 220 230 240 KSARPTGRGV EGLARVGSRA ALSFAFAFLR RAWRSGEDAD LCSELLQESL DALRALPEAS 250 260 270 280 290 300 LFDESTVSSV WLEVVERATR FLRSVVTGDV HGTPGTKGPG GVPLQDQHLA LAILLELAVQ 310 320 330 340 350 360 RGTLSQMLSA ILLLLQLWDS GAQETDNERS AQGTSAPLLP LLQRFQSIIC SKDVPHTESD 370 380 390 400 410 420 MHLLSGPLSP NESFLRYLTL PQDNELAIDL RQTAVVVMAH LDRLATPCMP PLCSSPTSHK 430 440 450 460 470 480 GSLQEVIGWG LIGWKYYANV IGPIQCEGLA SLGVMQVACA EKRFLILSRN GRVYTQAYNS 490 500 510 520 530 540 DMLAPQLVQG LASRNIVKIA AHSDGHHYLA LAATGEVYSW GCGDGGRLGH GDTVPLEEPK 550 560 570 580 590 600 VISAFSGKQA GKHVVHIACG STYSAAITAE GELYTWGRGN YGRLGHGSSE DEAIPMLVAG 610 620 630 640 650 660 LKGLKVIDVA CGSGDAQTLA VTENGQVWSW GDGDYGKLGR GGSDGCKTPK LIEKLQDLDV 670 680 690 700 710 720 IKVRCGSQFS IALTKDGQVY SWGKGDNQRL GHGTEEHVRY PKLLEGLQGK KVIDVAAGST 730 740 750 760 770 780 HCLALTEDSE VHSWGSNDQC QHFDTLRVTK PEPTALPGLD SKHIVGIACG PAQSFAWSSC 790 800 810 820 830 840 SEWSIGLRVP FVVDICSMTF EQLDLLLRQV SEGMDGTADW PPPQEKECMA VATLNLLRLQ 850 860 870 880 890 900 LHAAISHQVD PEFLGLGLGS VLLNSLKQTV VTLASSAGVL STVQSAAQAV LQSGWSVLLP 910 920 930 940 950 960 TAEERARALS ALLPCTVSGN EVNISPGRRF MIDLLVGSLM ADGGLESALN AAITAEIQDI 970 980 990 1000 1010 1020 EAKKEAQKEK EIDEQEASAS TFHRSRTPLD KDLINTGIYE SSGKQCLPLV QLIQQLLRNI 1030 1040 1050 1060 1070 1080 ASQTVARLKD VARRISSCLD FEQQSCERSA SLDLLLRFQR LLISKLYPGE KIGPISDTSS 1090 1100 1110 1120 1130 1140 PELMGVGSLL KKYTALVCTH IGDILPVAAS IASSSWQHFA EVACVMEGDF TGVLLPELVV 1150 1160 1170 1180 1190 1200 SIVLLLSKNA SLMQEAGAIP LLGGLLEHLD RFNHLAPGKE RDDHEELAWP GIMESFFTGQ 1210 1220 1230 1240 1250 1260 NCRNNEEVTL IRKADLENHN KDGGFWTVID GKVYGIKDFQ TQSLTGNSIL AQFAGEDPVV 1270 1280 1290 1300 1310 1320 ALEAALQFED TQESMHAFCV GQYLEPDQEV VTIPDLGSLS SPLIDTERNL GLLLGLHASY 1330 1340 1350 1360 1370 1380 LAMSTPLSPV EVECAKWLQS SIFSGGLQTS QIHYSYNEEK DEDHCSSPGG TPISKSRLCS 1390 1400 1410 1420 1430 1440 HRWALGDHSQ AFLQAIADNN IQDYNVKDFL CQIERYCRQC HLTTPITFPP EHPVEEVGRL 1450 1460 1470 1480 1490 1500 LLCCLLKHED LGHVALSLVH VGTLGIEQVK HRTLPKSVVD VCRVVYQAKC SLIKTHQEQG 1510 1520 1530 1540 1550 1560 RSYKEVCAPV IERLRFLFNE LRPAVCSDLS IMSKFKLLGS LPRWRRIAQK IIRERRKKRV 1570 1580 1590 1600 1610 1620 PKKPESIDSE EKIGNEESDL EEACVLPHSP INVDKRPISM KSPKDKWQPL LNTVTGVHKY 1630 1640 1650 1660 1670 1680 KWLKQNVQGL YPQSALLNTI VEFALKEEPV DVEKMRKCLL KQLERAEVRL EGIDTILKLA 1690 1700 1710 1720 1730 1740 AKSFLLPSVQ YAMFCGWQRL IPEGIDIGEP LTDCLRDVDL IPPFNRMLLE VTFGKLYAWA 1750 1760 1770 1780 1790 1800 VQNIRSVLMD ASARFKELGI QPVPLQTITN ENPAGPSLGT IPQARFLLVM LSMLTLQHGA 1810 1820 1830 1840 1850 1860 NNLDLLLNSG TLALTQTALR LIGPTCDSVE DDMNASARGA SATVLEETRK ETAPVQLPVS 1870 1880 1890 1900 1910 1920 GPELAAMMKI GTRVMRGVDW KWGDQDGPPP GLGRVIGELG EDGWIRVQWD TGSTNSYRMG 1930 1940 1950 1960 1970 1980 KEGKYDLKLV ELPVSSQPSA EDSDTEDDSE AEQGERNIHP TAMMLTSVIN LLQTLCLSVG 1990 2000 2010 2020 2030 2040 VHADIMQSEA TKTLCGLLRM LVESGTTDKP APPDRLVARE QHRSWCTLGF VRSIALTPQA 2050 2060 2070 2080 2090 2100 CGALSSPRWI TLLMKVVEGH APFTAASLQR QILAVHLLQA VLPSWDKTER ARDMKCLVEK 2110 2120 2130 2140 2150 2160 LFGFLGSLLT TCSSDVPLLR ESTLRKRRAR PQASLTATHS STLAEEVVGL LRTLHSLTQW 2170 2180 2190 2200 2210 2220 NGLINKYINS QLCSVTQSYA GKTSERAQLE DYFPDSENLE VGGLMAVLAV IGGIDGRLRL 2230 2240 2250 2260 2270 2280 GGQVMHDEFG EGTVTRITPK GRITVQFCDM RMCRVCPLNQ LKPLPAVAFS VNNLPFTEPM 2290 2300 2310 2320 2330 2340 LSVWAELVNL AGSKLEKHKT KKSAKPAFAG QVDLDLLRSQ QLKLYILKAG RALLSHQDKL 2350 2360 2370 2380 2390 2400 RQILSQPAVQ GTGTLQTDDG AAASPDLGDM SPEGPQPPMI LLQQLLSSAT QPSPVKAIFD 2410 2420 2430 2440 2450 2460 KQELEAAALA LCQCLAVEST HPSSPGCEDC SSSEATTPVS VQHIHLARAK KRRQSPAPAL 2470 2480 2490 2500 2510 2520 PIVVQLMEMG FPRKNIEFAL KSLTGTSGNA SGLPGVEALV GWLLDHSDVQ VTEFSDAETL 2530 2540 2550 2560 2570 2580 SDEYSDEEVV EDVDDTPYPV AAGAVVTESQ TYKKRADFLS NDDYAVYVRE NVQVGMMVRC 2590 2600 2610 2620 2630 2640 CRTYEEVCEG DVGKVIKLDR DGLHDLNVQC DWQQKGGTYW VRYIHVELIG YPPPSSSSHI 2650 2660 2670 2680 2690 2700 KIGDKVRVKA SVTTPKYKWG SVTHQSVGLV KAFSANGKDI IVDFPQQSHW TGLLSEMELV 2710 2720 2730 2740 2750 2760 PSIHPGVTCD GCQTFPINGS RFKCRNCDDF DFCETCFKTK KHNTRHTFGR INEPGQSAVF 2770 2780 2790 2800 2810 2820 CGRSGKQLKR CHSSQPGMLL DSWSRMVKSL NVSSSVNQAS RLIDGSEPCW QSSGSQGKHW 2830 2840 2850 2860 2870 2880 IRLEIFPDVL VHRLKMIVDP ADSSYMPSLV VVSGGNSLNN LIELKTININ QTDTTVPLLS 2890 2900 2910 2920 2930 2940 DCAEYHRYIE IAIKQCRSSG IDCKIHGLIL LGRIRAEEED LAAVPFLASD NEEEEDDKGS 2950 2960 2970 2980 2990 3000 TGSLIRKKTP GLESTATIRT KVFVWGLNDK DQLGGLKGSK IKVPSFSETL SALNVVQVAG 3010 3020 3030 3040 3050 3060 GSKSLFAVTV EGKVYSCGEA TNGRLGLGMS SGTVPIPRQI TALSSYVVKK VAVHSGGRHA 3070 3080 3090 3100 3110 3120 TALTVDGKVF SWGEGDDGKL GHFSRMNCDK PRLIEALKTK RIRDIACGSS HSAALTSSGE 3130 3140 3150 3160 3170 3180 LYTWGLGEYG RLGHGDNTTQ LKPKMVKVLL GHRVIQVACG SRDAQTLALT DEGLVFSWGD 3190 3200 3210 3220 3230 3240 GDFGKLGRGG SEGCNIPQNI ERLNGQGVCQ IECGAQFSLA LTKSGVVWTW GKGDYFRLGH 3250 3260 3270 3280 3290 3300 GSDVHVRKPQ VVEGLRGKKI VHVAVGALHC LAVTDSGQVY AWGDNDHGQQ GNGTTTVNRK 3310 3320 3330 3340 3350 3360 PTLVQGLEGQ KITRVACGSS HSVAWTTVDV ATPSVHEPVL FQTARDPLGA SYLGVPSDAD 3370 3380 3390 3400 3410 3420 SSSSSNKISG ANNCKPNRPS LAKILLSLEG NLAKQQALSH ILTALQIMYA RDAVVGALMP 3430 3440 3450 3460 3470 3480 AGMLAPVECP SFSSSAPASD VSAMASPMHM EDSTLAADLE DRLSPNLWQE KREIVSSEDA 3490 3500 3510 3520 3530 3540 VTPSAVTPSA PSASSRPFIP VTDDPGAASI IAETMTKTKE DVESQNKTSG PEPQSLDEFT 3550 3560 3570 3580 3590 3600 SLLIPDDTRV VVELLKLSVC SRAGDKGREV LSAVLSGMGT AYPQVADMLL ELCVTELEDV 3610 3620 3630 3640 3650 3660 ATDSQSGRLS SQPVVVESSH PYTDDTSTSG TVKIPGAEGL RVEFDRQCST ERRHDPLTVM 3670 3680 3690 3700 3710 3720 DGVNRIVSVR SGREWSDWSS ELRIPGDELK WKFISDGSVN GWGWRFTVYP IMPAAGPKDL 3730 3740 3750 3760 3770 3780 LSDRCVLSCP SMDLVTCLLD FRLNLTSNRS IVPRLAASLA ACAQLSALAA SHRMWALQRL 3790 3800 3810 3820 3830 3840 RRLLTTEFGQ SININRLLGE NDGESRALSF TGSALAALVK GLPEALQRQF EYEDPIVRGG 3850 3860 3870 3880 3890 3900 KQLLHSPFFK VLVALACDLE LDTLPCCAET HKWAWFRRYC MASRVAVALD KRTPLPRLFL 3910 3920 3930 3940 3950 3960 DEVAKKIREL MADSESMDVL HESHSIFKRE QDEQLVQWMN RRPDDWTLSA GGSGTIYGWG 3970 3980 3990 4000 4010 4020 HNHRGQLGGI EGAKVKVPTP CEALATLRPV QLIGGEQTLF AVTADGKLYA TGYGAGGRLG 4030 4040 4050 4060 4070 4080 IGGTESVSTP TLLESIQHVF IKKVAVNSGG KHCLALSSEG EVYSWGEAED GKLGHGNRSP 4090 4100 4110 4120 4130 4140 CDRPRVIESL RGIEVVDVAA GGAHSACVTA AGDLYTWGKG RYGRLGHSDS EDQLKPKLVE 4150 4160 4170 4180 4190 4200 ALQGHRVIDI ACGSGDAQTL CLTDDDTVWS WGDGDYGKLG RGGSDGCKVP MKIDSLTGLG 4210 4220 4230 4240 4250 4260 VVKVECGSQF SVALTKSGAV YTWGKGDYHR LGHGSDDHVR RPRQVQGLQG KKVIAIATGS 4270 4280 4290 4300 4310 4320 LHCVCCTEDG EVYTWGDNDE GQLGDGTTNA IQRPRLVAAL QGKKVNRVAC GSAHTLAWST 4330 4340 4350 4360 4370 4380 SKPASAGKLP AQVPMEYNHL QEIPIIALRN RLLLLHHISE LFCPCIPMFD LEGSLDETGL 4390 4400 4410 4420 4430 4440 GPSVGFDTLR GILISQGKEA AFRKVVQATM VRDRQHGPVV ELNRIQVKRS RSKGGLAGPD 4450 4460 4470 4480 4490 4500 GTKSVFGQMC AKMSSFSPDS LLLPHRVWKV KFVGESVDDC GGGYSESIAE ICEELQNGLT 4510 4520 4530 4540 4550 4560 PLLIVTPNGR DESGANRDCY LLNPATRAPV HCSMFRFLGV LLGIAIRTGS PLSLNLAEPV 4570 4580 4590 4600 4610 4620 WKQLAGMSLT IADLSEVDKD FIPGLMYIRD NEATSEEFEA MSLPFTVPSA SGQDIQLSSK 4630 4640 4650 4660 4670 4680 HTHITLDNRA EYVRLAINYR LHEFDEQVAA VREGMARVVP VPLLSLFTGY ELETMVCGSP 4690 4700 4710 4720 4730 4740 DIPLHLLKSV ATYKGIEPSA SLVQWFWEVM ESFSNTERSL FLRFVWGRTR LPRTIADFRG 4750 4760 4770 4780 4790 4800 RDFVIQVLDK YNPPDHFLPE SYTCFFLLKL PRYSCKQVLE EKLKYAIHFC KSIDTDDYAR 4810 4820 4830 IALTGEPAAD DSSEDSDNED ADSFASDSTQ DYLTGH
	Isoform 2 [UniParc]. Checksum: 3E3BA1D6DE63BAF7	FASTA	4,800	523,388
	10 20 30 40 50 60 MPSESFCLAA QSRLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIVYTGT ELAQNRELPL 70 80 90 100 110 120 RKDDGVDAQS GTKKEDLNDK EKKEEEETPA PVYRAKSILE SWVWGRQPDV NELKECLSVL 130 140 150 160 170 180 VKEQQALAVQ SATTTLSALR LKQRLVILER YFIALNRTVF QENVKVKWKS SSISVPPTEK 190 200 210 220 230 240 KSARPTGRGV EGLARVGSRA ALSFAFAFLR RAWRSGEDAD LCSELLQESL DALRALPEAS 250 260 270 280 290 300 LFDESTVSSV WLEVVERATR FLRSVVTGDV HGTPGTKGPG GVPLQDQHLA LAILLELAVQ 310 320 330 340 350 360 RGTLSQMLSA ILLLLQLWDS GAQETDNERS AQGTSAPLLP LLQRFQSIIC SKDVPHTESD 370 380 390 400 410 420 MHLLSGPLSP NESFLRYLTL PQDNELAIDL RQTAVVVMAH LDRLATPCMP PLCSSPTSHK 430 440 450 460 470 480 GSLQEVIGWG LIGWKYYANV IGPIQCEGLA SLGVMQVACA EKRFLILSRN GRVYTQAYNS 490 500 510 520 530 540 DMLAPQLVQG LASRNIVKIA AHSDGHHYLA LAATGEVYSW GCGDGGRLGH GDTVPLEEPK 550 560 570 580 590 600 VISAFSGKQA GKHVVHIACG STYSAAITAE GELYTWGRGN YGRLGHGSSE DEAIPMLVAG 610 620 630 640 650 660 LKGLKVIDVA CGSGDAQTLA VTENGQVWSW GDGDYGKLGR GGSDGCKTPK LIEKLQDLDV 670 680 690 700 710 720 IKVRCGSQFS IALTKDGQVY SWGKGDNQRL GHGTEEHVRY PKLLEGLQGK KVIDVAAGST 730 740 750 760 770 780 HCLALTEDSE VHSWGSNDQC QHFDTLRVTK PEPTALPGLD SKHIVGIACG PAQSFAWSSC 790 800 810 820 830 840 SEWSIGLRVP FVVDICSMTF EQLDLLLRQV SEGMDGTADW PPPQEKECMA VATLNLLRLQ 850 860 870 880 890 900 LHAAISHQVD PEFLGLGLGS VLLNSLKQTV VTLASSAGVL STVQSAAQAV LQSGWSVLLP 910 920 930 940 950 960 TAEERARALS ALLPCTVSGN EVNISPGRRF MIDLLVGSLM ADGGLESALN AAITAEIQDI 970 980 990 1000 1010 1020 EAKKEAQKEK EIDEQEASAS TFHRSRTPLD KDLINTGIYE SSGKQCLPLV QLIQQLLRNI 1030 1040 1050 1060 1070 1080 ASQTVARLKD VARRISSCLD FEQQSCERSA SLDLLLRFQR LLISKLYPGE KIGPISDTSS 1090 1100 1110 1120 1130 1140 PELMGVGSLL KKYTALVCTH IGDILPVAAS IASSSWQHFA EVACVMEGDF TGVLLPELVV 1150 1160 1170 1180 1190 1200 SIVLLLSKNA SLMQEAGAIP LLGGLLEHLD RFNHLAPGKE RDDHEELAWP GIMESFFTGQ 1210 1220 1230 1240 1250 1260 NCRNNEEVTL IRKADLENHN KDGGFWTVID GKVYGIKDFQ TQSLTGNSIL AQFAGEDPVV 1270 1280 1290 1300 1310 1320 ALEAALQFED TQESMHAFCV GQYLEPDQEV VTIPDLGSLS SPLIDTERNL GLLLGLHASY 1330 1340 1350 1360 1370 1380 LAMSTPLSPV EVECAKWLQS SIFSGGLQTS QIHYSYNEEK DEDHCSSPGG TPISKSRLCS 1390 1400 1410 1420 1430 1440 HRWALGDHSQ AFLQAIADNN IQDYNVKDFL CQIERYCRQC HLTTPITFPP EHPVEEVGRL 1450 1460 1470 1480 1490 1500 LLCCLLKHED LGHVALSLVH VGTLGIEQVK HRTLPKSVVD VCRVVYQAKC SLIKTHQEQG 1510 1520 1530 1540 1550 1560 RSYKEVCAPV IERLRFLFNE LRPAVCSDLS IMSKFKLLGS LPRWRRIAQK IIRERRKKRV 1570 1580 1590 1600 1610 1620 PKKPESIDSE EKIGNEESDL EEACVLPHSP INVDKRPISM KSPKDKWQPL LNTVTGVHKY 1630 1640 1650 1660 1670 1680 KWLKQNVQGL YPQSALLNTI VEFALKEEPV DVEKMRKCLL KQLERAEVRL EGIDTILKLA 1690 1700 1710 1720 1730 1740 AKSFLLPSVQ YAMFCGWQRL IPEGIDIGEP LTDCLRDVDL IPPFNRMLLE VTFGKLYAWA 1750 1760 1770 1780 1790 1800 VQNIRSVLMD ASARFKELGI QPVPLQTITN ENPAGPSLGT IPQARFLLVM LSMLTLQHGA 1810 1820 1830 1840 1850 1860 NNLDLLLNSG TLALTQTALR LIGPTCDSVE DDMNASARGA SATVLEETRK ETAPVQLPVS 1870 1880 1890 1900 1910 1920 GPELAAMMKI GTRVMRGVDW KWGDQDGPPP GLGRVIGELG EDGWIRVQWD TGSTNSYRMG 1930 1940 1950 1960 1970 1980 KEGKYDLKLV ELPVSSQPSA EDSDTEDDSE AEQGERNIHP TAMMLTSVIN LLQTLCLSVG 1990 2000 2010 2020 2030 2040 VHADIMQSEA TKTLCGLLRM LVESGTTDKP APPDRLVARE QHRSWCTLGF VRSIALTPQA 2050 2060 2070 2080 2090 2100 CGALSSPRWI TLLMKVVEGH APFTAASLQR QILAVHLLQA VLPSWDKTER ARDMKCLVEK 2110 2120 2130 2140 2150 2160 LFGFLGSLLT TCSSDVPLLR ESTLRKRRAR PQASLTATHS STLAEEVVGL LRTLHSLTQW 2170 2180 2190 2200 2210 2220 NGLINKYINS QLCSVTQSYA GKTSERAQLE DYFPDSENLE VGGLMAVLAV IGGIDGRLRL 2230 2240 2250 2260 2270 2280 GGQVMHDEFG EGTVTRITPK GRITVQFCDM RMCRVCPLNQ LKPLPAVAFS VNNLPFTEPM 2290 2300 2310 2320 2330 2340 LSVWAELVNL AGSKLEKHKT KKSAKPAFAG QVDLDLLRSQ QLKLYILKAG RALLSHQDKL 2350 2360 2370 2380 2390 2400 RQILSQPAVQ GTGTLQTDDG AAASPDLGDM SPEGPQPPMI LLQQLLSSAT QPSPVKAIFD 2410 2420 2430 2440 2450 2460 KQELEAAALA LCQCLAVEST HPSSPGCEDC SSSEATTPVS VQHIHLARAK KRRQSPAPAL 2470 2480 2490 2500 2510 2520 PIVVQLMEMG FPRKNIEFAL KSLTGTSGNA SGLPGVEALV GWLLDHSDVQ VTEFSDAETL 2530 2540 2550 2560 2570 2580 SDEYSDEEVV EDVDDTPYPV AAGAVVTESQ TYKKRADFLS NDDYAVYVRE NVQVGMMVRC 2590 2600 2610 2620 2630 2640 CRTYEEVCEG DVGKVIKLDR DGLHDLNVQC DWQQKGGTYW VRYIHVELIG YPPPSSSSHI 2650 2660 2670 2680 2690 2700 KIGDKVRVKA SVTTPKYKWG SVTHQSVGLV KAFSANGKDI IVDFPQQSHW TGLLSEMELV 2710 2720 2730 2740 2750 2760 PSIHPGVTCD GCQTFPINGS RFKCRNCDDF DFCETCFKTK KHNTRHTFGR INEPGQSAVF 2770 2780 2790 2800 2810 2820 CGRSGKQLKR CHSSQPGMLL DSWSRMVKSL NVSSSVNQAS RLIDGSEPCW QSSGSQGKHW 2830 2840 2850 2860 2870 2880 IRLEIFPDVL VHRLKMIVDP ADSSYMPSLV VVSGGNSLNN LIELKTININ QTDTTVPLLS 2890 2900 2910 2920 2930 2940 DCAEYHRYIE IAIKQCRSSG IDCKIHGLIL LGRIRAEEED LAAVPFLASD NEEEEDDKGS 2950 2960 2970 2980 2990 3000 TGSLIRKKTP GLESTATIRT KVFVWGLNDK DQLGGLKGSK IKVPSFSETL SALNVVQVAG 3010 3020 3030 3040 3050 3060 GSKSLFAVTV EGKVYSCGEA TNGRLGLGMS SGTVPIPRQI TALSSYVVKK VAVHSGGRHA 3070 3080 3090 3100 3110 3120 TALTVDGKVF SWGEGDDGKL GHFSRMNCDK PRLIEALKTK RIRDIACGSS HSAALTSSGE 3130 3140 3150 3160 3170 3180 LYTWGLGEYG RLGHGDNTTQ LKPKMVKVLL GHRVIQVACG SRDAQTLALT DEGLVFSWGD 3190 3200 3210 3220 3230 3240 GDFGKLGRGG SEGCNIPQNI ERLNGQGVCQ IECGAQFSLA LTKSGVVWTW GKGDYFRLGH 3250 3260 3270 3280 3290 3300 GSDVHVRKPQ VVEGLRGKKI VHVAVGALHC LAVTDSGQVY AWGDNDHGQQ GNGTTTVNRK 3310 3320 3330 3340 3350 3360 PTLVQGLEGQ KITRVACGSS HSVAWTTVDV ATPSVHEPVL FQTARDPLGA SYLGVPSDAD 3370 3380 3390 3400 3410 3420 SSSSSNKISG ANNCKPNRPS LAKILLSLEG NLAKQQALSH ILTALQIMYA RDAVVGALMP 3430 3440 3450 3460 3470 3480 AGMLAPVECP SFSSSAPASD VSAMASPMHM EDSTLAADLE DRLSPNLWQE KREIVSSEDA 3490 3500 3510 3520 3530 3540 VTPSAVTPSA PSASSRPFIP VTDDPGAASI IAETMTKTKE DVESQNKTSG PEPQSLDEFT 3550 3560 3570 3580 3590 3600 SLLIPDDTRV VVELLKLSVC SRAGDKGREV LSAVLSGMGT AYPQVADMLL ELCVTELEDV 3610 3620 3630 3640 3650 3660 ATDSQSGRLS SQPVVVESSH PYTDDTSTSG TVKIPGREWS DWSSELRIPG DELKWKFISD 3670 3680 3690 3700 3710 3720 GSVNGWGWRF TVYPIMPAAG PKDLLSDRCV LSCPSMDLVT CLLDFRLNLT SNRSIVPRLA 3730 3740 3750 3760 3770 3780 ASLAACAQLS ALAASHRMWA LQRLRRLLTT EFGQSININR LLGENDGESR ALSFTGSALA 3790 3800 3810 3820 3830 3840 ALVKGLPEAL QRQFEYEDPI VRGGKQLLHS PFFKVLVALA CDLELDTLPC CAETHKWAWF 3850 3860 3870 3880 3890 3900 RRYCMASRVA VALDKRTPLP RLFLDEVAKK IRELMADSES MDVLHESHSI FKREQDEQLV 3910 3920 3930 3940 3950 3960 QWMNRRPDDW TLSAGGSGTI YGWGHNHRGQ LGGIEGAKVK VPTPCEALAT LRPVQLIGGE 3970 3980 3990 4000 4010 4020 QTLFAVTADG KLYATGYGAG GRLGIGGTES VSTPTLLESI QHVFIKKVAV NSGGKHCLAL 4030 4040 4050 4060 4070 4080 SSEGEVYSWG EAEDGKLGHG NRSPCDRPRV IESLRGIEVV DVAAGGAHSA CVTAAGDLYT 4090 4100 4110 4120 4130 4140 WGKGRYGRLG HSDSEDQLKP KLVEALQGHR VIDIACGSGD AQTLCLTDDD TVWSWGDGDY 4150 4160 4170 4180 4190 4200 GKLGRGGSDG CKVPMKIDSL TGLGVVKVEC GSQFSVALTK SGAVYTWGKG DYHRLGHGSD 4210 4220 4230 4240 4250 4260 DHVRRPRQVQ GLQGKKVIAI ATGSLHCVCC TEDGEVYTWG DNDEGQLGDG TTNAIQRPRL 4270 4280 4290 4300 4310 4320 VAALQGKKVN RVACGSAHTL AWSTSKPASA GKLPAQVPME YNHLQEIPII ALRNRLLLLH 4330 4340 4350 4360 4370 4380 HISELFCPCI PMFDLEGSLD ETGLGPSVGF DTLRGILISQ GKEAAFRKVV QATMVRDRQH 4390 4400 4410 4420 4430 4440 GPVVELNRIQ VKRSRSKGGL AGPDGTKSVF GQMCAKMSSF SPDSLLLPHR VWKVKFVGES 4450 4460 4470 4480 4490 4500 VDDCGGGYSE SIAEICEELQ NGLTPLLIVT PNGRDESGAN RDCYLLNPAT RAPVHCSMFR 4510 4520 4530 4540 4550 4560 FLGVLLGIAI RTGSPLSLNL AEPVWKQLAG MSLTIADLSE VDKDFIPGLM YIRDNEATSE 4570 4580 4590 4600 4610 4620 EFEAMSLPFT VPSASGQDIQ LSSKHTHITL DNRAEYVRLA INYRLHEFDE QVAAVREGMA 4630 4640 4650 4660 4670 4680 RVVPVPLLSL FTGYELETMV CGSPDIPLHL LKSVATYKGI EPSASLVQWF WEVMESFSNT 4690 4700 4710 4720 4730 4740 ERSLFLRFVW GRTRLPRTIA DFRGRDFVIQ VLDKYNPPDH FLPESYTCFF LLKLPRYSCK 4750 4760 4770 4780 4790 4800 QVLEEKLKYA IHFCKSIDTD DYARIALTGE PAADDSSEDS DNEDADSFAS DSTQDYLTGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A very large novel protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice." Lehman A.L., Nakatsu Y., Ching A., Bronson R.T., Oakey R.J., Keiper-Hyrnko N., Finger J.N., Durham-Pierre D., Horton D.B., Newton J.M., Lyon M.F., Brilliant M.H. Proc. Natl. Acad. Sci. U.S.A. 95:9436-9441(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DISEASE. Strain: C57BL/6.
[2]	"The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities." Ji Y., Walkowicz M.J., Buiting K., Johnson D.K., Tarvin R.E., Rinchik E.M., Horsthemke B., Stubbs L., Nicholls R.D. Hum. Mol. Genet. 8:533-542(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DISEASE.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 953-1553; 1845-2470 AND 4123-4836. Strain: C57BL/6J. Tissue: Spinal cord, Testis and Vagina.
[5]	"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2966-4836 (ISOFORM 1). Tissue: Brain.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3618-4836 (ISOFORM 2). Strain: C57BL/6 and Czech II. Tissue: Mammary gland and Olfactory epithelium.
[7]	"Molecular characterization of radiation- and chemically induced mutations associated with neuromuscular tremors, runting, juvenile lethality, and sperm defects in jdf2 mice." Walkowicz M., Ji Y., Ren X., Horsthemke B., Russell L.B., Johnson D., Rinchik E.M., Nicholls R.D., Stubbs L. Mamm. Genome 10:870-878(1999) [PubMed] [Europe PMC] [Abstract] Cited for: DISEASE.
[8]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2929, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF061529 mRNA. Translation: AAC31431.1. AF071173 mRNA. Translation: AAD08658.1. AC102121 Genomic DNA. No translation available. AC102150 Genomic DNA. No translation available. AK141515 mRNA. Translation: BAE24711.1. AK148361 mRNA. Translation: BAE28504.1. AK161826 mRNA. Translation: BAE36593.1. AK162270 mRNA. Translation: BAE36828.1. AK162708 mRNA. Translation: BAE37031.1. AK220338 mRNA. Translation: BAD90404.1. BC044667 mRNA. Translation: AAH44667.1. BC054829 mRNA. Translation: AAH54829.1.
IPI	IPI00309574. IPI00314989.
RefSeq	NP_034548.2. NM_010418.2.
UniGene	Mm.20929.
3D structure databases
ProteinModelPortal	Q4U2R1.
SMR	Q4U2R1. Positions 1206-1297, 1868-1929, 3955-4320.
ModBase	Search...
PTM databases
PhosphoSite	Q4U2R1.
Proteomic databases
PaxDb	Q4U2R1.
PRIDE	Q4U2R1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000076226; ENSMUSP00000075579; ENSMUSG00000030451. ENSMUST00000164095; ENSMUSP00000131573; ENSMUSG00000030451.
GeneID	15204.
KEGG	mmu:15204.
UCSC	uc009hdv.1. mouse.
Organism-specific databases
CTD	8924.
MGI	MGI:103234. Herc2.
Rouge	Search...
Phylogenomic databases
eggNOG	COG5021.
GeneTree	ENSGT00700000104208.
HOVERGEN	HBG081598.
InParanoid	Q4U2R1.
KO	K10595.
OMA	QLAFTRD.
OrthoDB	EOG41C6V9.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
Bgee	Q4U2R1.
Genevestigator	Q4U2R1.
GermOnline	ENSMUSG00000030451. Mus musculus.
Family and domain databases
Gene3D	2.130.10.30. 3 hits. 2.30.30.30. 1 hit. 2.60.120.260. 1 hit. 3.10.120.10. 1 hit.
InterPro	IPR004939. APC_su10/DOC_dom. IPR006624. Beta-propeller_rpt_TECPR. IPR021097. CPH_domain. IPR001199. Cyt_B5-like_heme/steroid-bd. IPR008979. Galactose-bd-like. IPR000569. HECT. IPR010606. Mib_Herc2. IPR009091. RCC1/BLIP-II. IPR000408. Reg_chr_condens. IPR014722. Rib_L2_dom2. IPR000433. Znf_ZZ. [Graphical view]
Pfam	PF03256. APC10. 1 hit. PF11515. Cul7. 1 hit. PF00173. Cyt-b5. 1 hit. PF00632. HECT. 1 hit. PF06701. MIB_HERC2. 1 hit. PF00415. RCC1. 17 hits. PF00569. ZZ. 1 hit. [Graphical view]
PRINTS	PR00633. RCCNDNSATION.
SMART	SM00119. HECTc. 1 hit. SM00706. TECPR. 4 hits. SM00291. ZnF_ZZ. 1 hit. [Graphical view]
SUPFAM	SSF55856. Cyt_B5. 1 hit. SSF49785. Gal_bind_like. 1 hit. SSF56204. HECT. 1 hit. SSF50985. RCC1/BLIP-II. 3 hits.
PROSITE	PS00191. CYTOCHROME_B5_1. False negative. PS50255. CYTOCHROME_B5_2. 1 hit. PS51284. DOC. 1 hit. PS50237. HECT. 1 hit. PS51416. MIB_HERC2. 1 hit. PS00625. RCC1_1. False negative. PS00626. RCC1_2. 1 hit. PS50012. RCC1_3. 19 hits. PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. PS01357. ZF_ZZ_1. 1 hit. PS50135. ZF_ZZ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HERC2. mouse.
NextBio	287753.
SOURCE	Search...

Entry information

Entry name

HERC2_MOUSE

Accession

Primary (citable) accession number: Q4U2R1
Secondary accession number(s): E9PZT6 , O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	July 27, 2011
Last modified:	May 29, 2013
This is version 79 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program