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Q4U2R1 (HERC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase HERC2

EC=6.3.2.-
Alternative name(s):
HECT domain and RCC1-like domain-containing protein 2
Gene names
Name:Herc2
Synonyms:Jdf2, Kiaa0393, Rjs
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length4836 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts (when phosphorylated at Thr-4829 and sumoylated) with RNF8 (via FHA domain); this interaction increases after ionising radiation (IR) treatment. Interacts with XPA By similarity. Interacts with NEURL4. Via its interaction with NEURL4, may indirectly interact with CCP110 and CEP97 By similarity.

Subcellular location

Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity. Nucleus By similarity. Note: Recruited to sites of DNA damage in response to ionising radiation (IR) via its interaction with RNF8 By similarity. May loose association with centrosomes during mitosis By similarity.

Tissue specificity

Highest levels are found in brain and testis with lower levels in heart, lung, liver, skeletal muscle and kidney. Little expression detected in spleen. Ref.1

Domain

The ZZ-type zinc finger mediates binding to SUMO1, and at lowe level SUMO2 By similarity.

The RCC1 repeats are grouped into three seven-bladed beta-propeller regions By similarity.

Post-translational modification

Phosphorylation at Thr-4829 is required for interaction with RNF8.

Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs), promoting the interaction with RNF8 By similarity.

Involvement in disease

Defects in Herc2 are the cause of the runty, jerky, sterile phenotype (rjs), also known as the juvenile development and fertility phenotype (jfd2), which is characterized by reduced size, jerky gait, fertility problems including spermatocyte and oocyte abnormalities, defective maternal behavior and reduced lifespan with juvenile lethality. Ref.1 Ref.2 Ref.7

Sequence similarities

Contains 1 cytochrome b5 heme-binding domain.

Contains 1 DOC domain.

Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.

Contains 1 MIB/HERC2 domain.

Contains 21 RCC1 repeats.

Contains 1 ZZ-type zinc finger.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
Ubl conjugation pathway
   Cellular componentCytoplasm
Cytoskeleton
Nucleus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Repeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionLigase
   PTMPhosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA repair

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to DNA damage stimulus

Inferred from sequence or structural similarity. Source: UniProtKB

protein ubiquitination

Inferred from sequence or structural similarity. Source: UniProtKB

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Inferred from Biological aspect of Ancestor. Source: RefGenome

spermatogenesis

Inferred from mutant phenotype PubMed 5565073. Source: MGI

   Cellular_componentcentriole

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

mitochondrial inner membrane

Inferred from direct assay PubMed 12865426. Source: MGI

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionSUMO binding

Inferred from sequence or structural similarity. Source: UniProtKB

heme binding

Inferred from electronic annotation. Source: InterPro

ubiquitin-protein transferase activity

Inferred from sequence or structural similarity. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 Ref.2 (identifier: Q4U2R1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.6 (identifier: Q4U2R1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     3637-3672: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 48364836E3 ubiquitin-protein ligase HERC2
PRO_0000229740

Regions

Repeat416 – 46247RCC1 1-1
Repeat463 – 51351RCC1 1-2
Repeat514 – 56956RCC1 1-3
Repeat570 – 62152RCC1 1-4
Repeat624 – 67552RCC1 1-5
Repeat676 – 72752RCC1 1-6
Repeat729 – 77951RCC1 1-7
Domain1208 – 128477Cytochrome b5 heme-binding
Domain1860 – 193374MIB/HERC2
Domain2760 – 2937178DOC
Repeat2959 – 301052RCC1 2-1
Repeat3011 – 306555RCC1 2-2
Repeat3066 – 311752RCC1 2-3
Repeat3119 – 316951RCC1 2-4
Repeat3172 – 322352RCC1 2-5
Repeat3225 – 327551RCC1 2-6
Repeat3276 – 332752RCC1 2-7
Repeat3953 – 400452RCC1 3-1
Repeat4006 – 405853RCC1 3-2
Repeat4060 – 411051RCC1 3-3
Repeat4112 – 416453RCC1 3-4
Repeat4166 – 421651RCC1 3-5
Repeat4218 – 426851RCC1 3-6
Repeat4270 – 432051RCC1 3-7
Domain4459 – 4796338HECT
Zinc finger2703 – 275048ZZ-type
Coiled coil948 – 98134 Potential

Sites

Active site47641Glycyl thioester intermediate By similarity

Amino acid modifications

Modified residue6481Phosphothreonine By similarity
Modified residue15781Phosphoserine Ref.8
Modified residue19451Phosphothreonine By similarity
Modified residue24551Phosphoserine By similarity
Modified residue29291Phosphoserine By similarity
Modified residue48121Phosphoserine By similarity
Modified residue48131Phosphoserine By similarity
Modified residue48161Phosphoserine By similarity
Modified residue48291Phosphothreonine By similarity

Natural variations

Alternative sequence3637 – 367236Missing in isoform 2. Ref.6
VSP_051975

Experimental info

Sequence conflict6921H → L in AAC31431. Ref.1
Sequence conflict7241A → V in AAD08658. Ref.2
Sequence conflict7471R → G in AAD08658. Ref.2
Sequence conflict7561L → F in AAD08658. Ref.2
Sequence conflict9291R → P in AAD08658. Ref.2
Sequence conflict11141S → N in AAD08658. Ref.2
Sequence conflict12351G → D in AAD08658. Ref.2
Sequence conflict23481A → P in AAC31431. Ref.1
Sequence conflict24701G → S in BAE36828. Ref.4
Sequence conflict25231E → D in AAC31431. Ref.1
Sequence conflict25671Y → F in AAC31431. Ref.1
Sequence conflict25721V → L in AAC31431. Ref.1
Sequence conflict30951E → Q in AAD08658. Ref.2
Sequence conflict31071C → Y in AAD08658. Ref.2
Sequence conflict31141A → P in AAD08658. Ref.2
Sequence conflict31611S → T in AAC31431. Ref.1
Sequence conflict3385 – 33862LL → VV in AAD08658. Ref.2
Sequence conflict35081A → V in AAD08658. Ref.2
Sequence conflict40691E → K in BAD90404. Ref.5
Sequence conflict41871C → S in AAC31431. Ref.1
Sequence conflict46041P → S in BAE36593. Ref.4
Sequence conflict47161T → A in AAC31431. Ref.1
Sequence conflict47231R → C in AAD08658. Ref.2
Sequence conflict47301R → S in AAC31431. Ref.1
Sequence conflict47521N → Y in AAC31431. Ref.1
Sequence conflict47901C → S in AAC31431. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 481BC90E231C93D8

FASTA4,836527,456
        10         20         30         40         50         60 
MPSESFCLAA QSRLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIVYTGT ELAQNRELPL 

        70         80         90        100        110        120 
RKDDGVDAQS GTKKEDLNDK EKKEEEETPA PVYRAKSILE SWVWGRQPDV NELKECLSVL 

       130        140        150        160        170        180 
VKEQQALAVQ SATTTLSALR LKQRLVILER YFIALNRTVF QENVKVKWKS SSISVPPTEK 

       190        200        210        220        230        240 
KSARPTGRGV EGLARVGSRA ALSFAFAFLR RAWRSGEDAD LCSELLQESL DALRALPEAS 

       250        260        270        280        290        300 
LFDESTVSSV WLEVVERATR FLRSVVTGDV HGTPGTKGPG GVPLQDQHLA LAILLELAVQ 

       310        320        330        340        350        360 
RGTLSQMLSA ILLLLQLWDS GAQETDNERS AQGTSAPLLP LLQRFQSIIC SKDVPHTESD 

       370        380        390        400        410        420 
MHLLSGPLSP NESFLRYLTL PQDNELAIDL RQTAVVVMAH LDRLATPCMP PLCSSPTSHK 

       430        440        450        460        470        480 
GSLQEVIGWG LIGWKYYANV IGPIQCEGLA SLGVMQVACA EKRFLILSRN GRVYTQAYNS 

       490        500        510        520        530        540 
DMLAPQLVQG LASRNIVKIA AHSDGHHYLA LAATGEVYSW GCGDGGRLGH GDTVPLEEPK 

       550        560        570        580        590        600 
VISAFSGKQA GKHVVHIACG STYSAAITAE GELYTWGRGN YGRLGHGSSE DEAIPMLVAG 

       610        620        630        640        650        660 
LKGLKVIDVA CGSGDAQTLA VTENGQVWSW GDGDYGKLGR GGSDGCKTPK LIEKLQDLDV 

       670        680        690        700        710        720 
IKVRCGSQFS IALTKDGQVY SWGKGDNQRL GHGTEEHVRY PKLLEGLQGK KVIDVAAGST 

       730        740        750        760        770        780 
HCLALTEDSE VHSWGSNDQC QHFDTLRVTK PEPTALPGLD SKHIVGIACG PAQSFAWSSC 

       790        800        810        820        830        840 
SEWSIGLRVP FVVDICSMTF EQLDLLLRQV SEGMDGTADW PPPQEKECMA VATLNLLRLQ 

       850        860        870        880        890        900 
LHAAISHQVD PEFLGLGLGS VLLNSLKQTV VTLASSAGVL STVQSAAQAV LQSGWSVLLP 

       910        920        930        940        950        960 
TAEERARALS ALLPCTVSGN EVNISPGRRF MIDLLVGSLM ADGGLESALN AAITAEIQDI 

       970        980        990       1000       1010       1020 
EAKKEAQKEK EIDEQEASAS TFHRSRTPLD KDLINTGIYE SSGKQCLPLV QLIQQLLRNI 

      1030       1040       1050       1060       1070       1080 
ASQTVARLKD VARRISSCLD FEQQSCERSA SLDLLLRFQR LLISKLYPGE KIGPISDTSS 

      1090       1100       1110       1120       1130       1140 
PELMGVGSLL KKYTALVCTH IGDILPVAAS IASSSWQHFA EVACVMEGDF TGVLLPELVV 

      1150       1160       1170       1180       1190       1200 
SIVLLLSKNA SLMQEAGAIP LLGGLLEHLD RFNHLAPGKE RDDHEELAWP GIMESFFTGQ 

      1210       1220       1230       1240       1250       1260 
NCRNNEEVTL IRKADLENHN KDGGFWTVID GKVYGIKDFQ TQSLTGNSIL AQFAGEDPVV 

      1270       1280       1290       1300       1310       1320 
ALEAALQFED TQESMHAFCV GQYLEPDQEV VTIPDLGSLS SPLIDTERNL GLLLGLHASY 

      1330       1340       1350       1360       1370       1380 
LAMSTPLSPV EVECAKWLQS SIFSGGLQTS QIHYSYNEEK DEDHCSSPGG TPISKSRLCS 

      1390       1400       1410       1420       1430       1440 
HRWALGDHSQ AFLQAIADNN IQDYNVKDFL CQIERYCRQC HLTTPITFPP EHPVEEVGRL 

      1450       1460       1470       1480       1490       1500 
LLCCLLKHED LGHVALSLVH VGTLGIEQVK HRTLPKSVVD VCRVVYQAKC SLIKTHQEQG 

      1510       1520       1530       1540       1550       1560 
RSYKEVCAPV IERLRFLFNE LRPAVCSDLS IMSKFKLLGS LPRWRRIAQK IIRERRKKRV 

      1570       1580       1590       1600       1610       1620 
PKKPESIDSE EKIGNEESDL EEACVLPHSP INVDKRPISM KSPKDKWQPL LNTVTGVHKY 

      1630       1640       1650       1660       1670       1680 
KWLKQNVQGL YPQSALLNTI VEFALKEEPV DVEKMRKCLL KQLERAEVRL EGIDTILKLA 

      1690       1700       1710       1720       1730       1740 
AKSFLLPSVQ YAMFCGWQRL IPEGIDIGEP LTDCLRDVDL IPPFNRMLLE VTFGKLYAWA 

      1750       1760       1770       1780       1790       1800 
VQNIRSVLMD ASARFKELGI QPVPLQTITN ENPAGPSLGT IPQARFLLVM LSMLTLQHGA 

      1810       1820       1830       1840       1850       1860 
NNLDLLLNSG TLALTQTALR LIGPTCDSVE DDMNASARGA SATVLEETRK ETAPVQLPVS 

      1870       1880       1890       1900       1910       1920 
GPELAAMMKI GTRVMRGVDW KWGDQDGPPP GLGRVIGELG EDGWIRVQWD TGSTNSYRMG 

      1930       1940       1950       1960       1970       1980 
KEGKYDLKLV ELPVSSQPSA EDSDTEDDSE AEQGERNIHP TAMMLTSVIN LLQTLCLSVG 

      1990       2000       2010       2020       2030       2040 
VHADIMQSEA TKTLCGLLRM LVESGTTDKP APPDRLVARE QHRSWCTLGF VRSIALTPQA 

      2050       2060       2070       2080       2090       2100 
CGALSSPRWI TLLMKVVEGH APFTAASLQR QILAVHLLQA VLPSWDKTER ARDMKCLVEK 

      2110       2120       2130       2140       2150       2160 
LFGFLGSLLT TCSSDVPLLR ESTLRKRRAR PQASLTATHS STLAEEVVGL LRTLHSLTQW 

      2170       2180       2190       2200       2210       2220 
NGLINKYINS QLCSVTQSYA GKTSERAQLE DYFPDSENLE VGGLMAVLAV IGGIDGRLRL 

      2230       2240       2250       2260       2270       2280 
GGQVMHDEFG EGTVTRITPK GRITVQFCDM RMCRVCPLNQ LKPLPAVAFS VNNLPFTEPM 

      2290       2300       2310       2320       2330       2340 
LSVWAELVNL AGSKLEKHKT KKSAKPAFAG QVDLDLLRSQ QLKLYILKAG RALLSHQDKL 

      2350       2360       2370       2380       2390       2400 
RQILSQPAVQ GTGTLQTDDG AAASPDLGDM SPEGPQPPMI LLQQLLSSAT QPSPVKAIFD 

      2410       2420       2430       2440       2450       2460 
KQELEAAALA LCQCLAVEST HPSSPGCEDC SSSEATTPVS VQHIHLARAK KRRQSPAPAL 

      2470       2480       2490       2500       2510       2520 
PIVVQLMEMG FPRKNIEFAL KSLTGTSGNA SGLPGVEALV GWLLDHSDVQ VTEFSDAETL 

      2530       2540       2550       2560       2570       2580 
SDEYSDEEVV EDVDDTPYPV AAGAVVTESQ TYKKRADFLS NDDYAVYVRE NVQVGMMVRC 

      2590       2600       2610       2620       2630       2640 
CRTYEEVCEG DVGKVIKLDR DGLHDLNVQC DWQQKGGTYW VRYIHVELIG YPPPSSSSHI 

      2650       2660       2670       2680       2690       2700 
KIGDKVRVKA SVTTPKYKWG SVTHQSVGLV KAFSANGKDI IVDFPQQSHW TGLLSEMELV 

      2710       2720       2730       2740       2750       2760 
PSIHPGVTCD GCQTFPINGS RFKCRNCDDF DFCETCFKTK KHNTRHTFGR INEPGQSAVF 

      2770       2780       2790       2800       2810       2820 
CGRSGKQLKR CHSSQPGMLL DSWSRMVKSL NVSSSVNQAS RLIDGSEPCW QSSGSQGKHW 

      2830       2840       2850       2860       2870       2880 
IRLEIFPDVL VHRLKMIVDP ADSSYMPSLV VVSGGNSLNN LIELKTININ QTDTTVPLLS 

      2890       2900       2910       2920       2930       2940 
DCAEYHRYIE IAIKQCRSSG IDCKIHGLIL LGRIRAEEED LAAVPFLASD NEEEEDDKGS 

      2950       2960       2970       2980       2990       3000 
TGSLIRKKTP GLESTATIRT KVFVWGLNDK DQLGGLKGSK IKVPSFSETL SALNVVQVAG 

      3010       3020       3030       3040       3050       3060 
GSKSLFAVTV EGKVYSCGEA TNGRLGLGMS SGTVPIPRQI TALSSYVVKK VAVHSGGRHA 

      3070       3080       3090       3100       3110       3120 
TALTVDGKVF SWGEGDDGKL GHFSRMNCDK PRLIEALKTK RIRDIACGSS HSAALTSSGE 

      3130       3140       3150       3160       3170       3180 
LYTWGLGEYG RLGHGDNTTQ LKPKMVKVLL GHRVIQVACG SRDAQTLALT DEGLVFSWGD 

      3190       3200       3210       3220       3230       3240 
GDFGKLGRGG SEGCNIPQNI ERLNGQGVCQ IECGAQFSLA LTKSGVVWTW GKGDYFRLGH 

      3250       3260       3270       3280       3290       3300 
GSDVHVRKPQ VVEGLRGKKI VHVAVGALHC LAVTDSGQVY AWGDNDHGQQ GNGTTTVNRK 

      3310       3320       3330       3340       3350       3360 
PTLVQGLEGQ KITRVACGSS HSVAWTTVDV ATPSVHEPVL FQTARDPLGA SYLGVPSDAD 

      3370       3380       3390       3400       3410       3420 
SSSSSNKISG ANNCKPNRPS LAKILLSLEG NLAKQQALSH ILTALQIMYA RDAVVGALMP 

      3430       3440       3450       3460       3470       3480 
AGMLAPVECP SFSSSAPASD VSAMASPMHM EDSTLAADLE DRLSPNLWQE KREIVSSEDA 

      3490       3500       3510       3520       3530       3540 
VTPSAVTPSA PSASSRPFIP VTDDPGAASI IAETMTKTKE DVESQNKTSG PEPQSLDEFT 

      3550       3560       3570       3580       3590       3600 
SLLIPDDTRV VVELLKLSVC SRAGDKGREV LSAVLSGMGT AYPQVADMLL ELCVTELEDV 

      3610       3620       3630       3640       3650       3660 
ATDSQSGRLS SQPVVVESSH PYTDDTSTSG TVKIPGAEGL RVEFDRQCST ERRHDPLTVM 

      3670       3680       3690       3700       3710       3720 
DGVNRIVSVR SGREWSDWSS ELRIPGDELK WKFISDGSVN GWGWRFTVYP IMPAAGPKDL 

      3730       3740       3750       3760       3770       3780 
LSDRCVLSCP SMDLVTCLLD FRLNLTSNRS IVPRLAASLA ACAQLSALAA SHRMWALQRL 

      3790       3800       3810       3820       3830       3840 
RRLLTTEFGQ SININRLLGE NDGESRALSF TGSALAALVK GLPEALQRQF EYEDPIVRGG 

      3850       3860       3870       3880       3890       3900 
KQLLHSPFFK VLVALACDLE LDTLPCCAET HKWAWFRRYC MASRVAVALD KRTPLPRLFL 

      3910       3920       3930       3940       3950       3960 
DEVAKKIREL MADSESMDVL HESHSIFKRE QDEQLVQWMN RRPDDWTLSA GGSGTIYGWG 

      3970       3980       3990       4000       4010       4020 
HNHRGQLGGI EGAKVKVPTP CEALATLRPV QLIGGEQTLF AVTADGKLYA TGYGAGGRLG 

      4030       4040       4050       4060       4070       4080 
IGGTESVSTP TLLESIQHVF IKKVAVNSGG KHCLALSSEG EVYSWGEAED GKLGHGNRSP 

      4090       4100       4110       4120       4130       4140 
CDRPRVIESL RGIEVVDVAA GGAHSACVTA AGDLYTWGKG RYGRLGHSDS EDQLKPKLVE 

      4150       4160       4170       4180       4190       4200 
ALQGHRVIDI ACGSGDAQTL CLTDDDTVWS WGDGDYGKLG RGGSDGCKVP MKIDSLTGLG 

      4210       4220       4230       4240       4250       4260 
VVKVECGSQF SVALTKSGAV YTWGKGDYHR LGHGSDDHVR RPRQVQGLQG KKVIAIATGS 

      4270       4280       4290       4300       4310       4320 
LHCVCCTEDG EVYTWGDNDE GQLGDGTTNA IQRPRLVAAL QGKKVNRVAC GSAHTLAWST 

      4330       4340       4350       4360       4370       4380 
SKPASAGKLP AQVPMEYNHL QEIPIIALRN RLLLLHHISE LFCPCIPMFD LEGSLDETGL 

      4390       4400       4410       4420       4430       4440 
GPSVGFDTLR GILISQGKEA AFRKVVQATM VRDRQHGPVV ELNRIQVKRS RSKGGLAGPD 

      4450       4460       4470       4480       4490       4500 
GTKSVFGQMC AKMSSFSPDS LLLPHRVWKV KFVGESVDDC GGGYSESIAE ICEELQNGLT 

      4510       4520       4530       4540       4550       4560 
PLLIVTPNGR DESGANRDCY LLNPATRAPV HCSMFRFLGV LLGIAIRTGS PLSLNLAEPV 

      4570       4580       4590       4600       4610       4620 
WKQLAGMSLT IADLSEVDKD FIPGLMYIRD NEATSEEFEA MSLPFTVPSA SGQDIQLSSK 

      4630       4640       4650       4660       4670       4680 
HTHITLDNRA EYVRLAINYR LHEFDEQVAA VREGMARVVP VPLLSLFTGY ELETMVCGSP 

      4690       4700       4710       4720       4730       4740 
DIPLHLLKSV ATYKGIEPSA SLVQWFWEVM ESFSNTERSL FLRFVWGRTR LPRTIADFRG 

      4750       4760       4770       4780       4790       4800 
RDFVIQVLDK YNPPDHFLPE SYTCFFLLKL PRYSCKQVLE EKLKYAIHFC KSIDTDDYAR 

      4810       4820       4830 
IALTGEPAAD DSSEDSDNED ADSFASDSTQ DYLTGH 

« Hide

Isoform 2 [UniParc].

Checksum: 3E3BA1D6DE63BAF7
Show »

FASTA4,800523,388

References

« Hide 'large scale' references
[1]"A very large novel protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice."
Lehman A.L., Nakatsu Y., Ching A., Bronson R.T., Oakey R.J., Keiper-Hyrnko N., Finger J.N., Durham-Pierre D., Horton D.B., Newton J.M., Lyon M.F., Brilliant M.H.
Proc. Natl. Acad. Sci. U.S.A. 95:9436-9441(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DISEASE.
Strain: C57BL/6.
[2]"The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities."
Ji Y., Walkowicz M.J., Buiting K., Johnson D.K., Tarvin R.E., Rinchik E.M., Horsthemke B., Stubbs L., Nicholls R.D.
Hum. Mol. Genet. 8:533-542(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DISEASE.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 953-1553; 1845-2470 AND 4123-4836.
Strain: C57BL/6J.
Tissue: Spinal cord, Testis and Vagina.
[5]"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2966-4836 (ISOFORM 1).
Tissue: Brain.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3618-4836 (ISOFORM 2).
Strain: C57BL/6 and Czech II.
Tissue: Mammary gland and Olfactory epithelium.
[7]"Molecular characterization of radiation- and chemically induced mutations associated with neuromuscular tremors, runting, juvenile lethality, and sperm defects in jdf2 mice."
Walkowicz M., Ji Y., Ren X., Horsthemke B., Russell L.B., Johnson D., Rinchik E.M., Nicholls R.D., Stubbs L.
Mamm. Genome 10:870-878(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: DISEASE.
[8]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1578, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF061529 mRNA. Translation: AAC31431.1.
AF071173 mRNA. Translation: AAD08658.1.
AC102121 Genomic DNA. No translation available.
AC102150 Genomic DNA. No translation available.
AK141515 mRNA. Translation: BAE24711.1.
AK148361 mRNA. Translation: BAE28504.1.
AK161826 mRNA. Translation: BAE36593.1.
AK162270 mRNA. Translation: BAE36828.1.
AK162708 mRNA. Translation: BAE37031.1.
AK220338 mRNA. Translation: BAD90404.1.
BC044667 mRNA. Translation: AAH44667.1.
BC054829 mRNA. Translation: AAH54829.1.
CCDSCCDS21318.1. [Q4U2R1-1]
RefSeqNP_034548.2. NM_010418.2. [Q4U2R1-1]
XP_006540700.1. XM_006540637.1. [Q4U2R1-1]
XP_006540701.1. XM_006540638.1. [Q4U2R1-1]
XP_006540702.1. XM_006540639.1. [Q4U2R1-2]
UniGeneMm.20929.

3D structure databases

ProteinModelPortalQ4U2R1.
SMRQ4U2R1. Positions 423-780, 1206-1297, 1868-1929, 3955-4320.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200274. 2 interactions.

PTM databases

PhosphoSiteQ4U2R1.

Proteomic databases

MaxQBQ4U2R1.
PaxDbQ4U2R1.
PRIDEQ4U2R1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000076226; ENSMUSP00000075579; ENSMUSG00000030451. [Q4U2R1-1]
ENSMUST00000164095; ENSMUSP00000131573; ENSMUSG00000030451. [Q4U2R1-1]
GeneID15204.
KEGGmmu:15204.
UCSCuc009hdv.1. mouse. [Q4U2R1-1]

Organism-specific databases

CTD8924.
MGIMGI:103234. Herc2.
RougeSearch...

Phylogenomic databases

eggNOGCOG5021.
GeneTreeENSGT00750000117470.
HOVERGENHBG081598.
InParanoidQ4U2R1.
KOK10595.
OMAGHGTDVH.
OrthoDBEOG70KGNN.
TreeFamTF320636.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

BgeeQ4U2R1.
GenevestigatorQ4U2R1.

Family and domain databases

Gene3D2.130.10.30. 3 hits.
2.30.30.30. 1 hit.
2.60.120.260. 1 hit.
3.10.120.10. 1 hit.
InterProIPR004939. APC_su10/DOC_dom.
IPR006624. Beta-propeller_rpt_TECPR.
IPR021097. CPH_domain.
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR008979. Galactose-bd-like.
IPR000569. HECT.
IPR010606. Mib_Herc2.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR014722. Rib_L2_dom2.
IPR000433. Znf_ZZ.
[Graphical view]
PfamPF03256. APC10. 1 hit.
PF11515. Cul7. 1 hit.
PF00173. Cyt-b5. 1 hit.
PF00632. HECT. 1 hit.
PF06701. MIB_HERC2. 1 hit.
PF00415. RCC1. 18 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
PRINTSPR00633. RCCNDNSATION.
SMARTSM00119. HECTc. 1 hit.
SM00706. TECPR. 4 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMSSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 3 hits.
SSF55856. SSF55856. 1 hit.
SSF56204. SSF56204. 1 hit.
PROSITEPS50255. CYTOCHROME_B5_2. 1 hit.
PS51284. DOC. 1 hit.
PS50237. HECT. 1 hit.
PS51416. MIB_HERC2. 1 hit.
PS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 19 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHERC2. mouse.
NextBio287753.
PROQ4U2R1.
SOURCESearch...

Entry information

Entry nameHERC2_MOUSE
AccessionPrimary (citable) accession number: Q4U2R1
Secondary accession number(s): E9PZT6 expand/collapse secondary AC list , O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot