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Q4U108

- Q4U108_MOUSE

UniProt

Q4U108 - Q4U108_MOUSE

Protein
Submitted name:

NF-kB2 splice variant 1

Gene

Nfkb2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. extracellular matrix organization Source: MGI
    2. follicular dendritic cell differentiation Source: MGI
    3. germinal center formation Source: MGI
    4. lymph node development Source: MGI
    5. NIK/NF-kappaB signaling Source: MGI
    6. spleen development Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    NF-kB2 splice variant 1Imported
    Gene namesi
    Name:Nfkb2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1099800. Nfkb2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ4U108.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4U108.
    SMRiQ4U108. Positions 37-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 6 ANK repeats.UniRule annotation

    Keywords - Domaini

    ANK repeatUniRule annotation, RepeatUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG052613.
    InParanoidiQ4U108.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR000451. NF_Rel_Dor.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    PF12796. Ank_2. 2 hits.
    PF00554. RHD. 1 hit.
    [Graphical view]
    PRINTSiPR00057. NFKBTNSCPFCT.
    SMARTiSM00248. ANK. 6 hits.
    SM00429. IPT. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    PS01204. REL_1. 1 hit.
    PS50254. REL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4U108-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNCYDPGLD GIPEYDDFEF SPSIVEPKDP APETADGPYL VIVEQPKQRG    50
    FRFRYGCEGP SHGGLPGASS EKGRKTYPTV KICNYEGPAK IGVDLVTHSD 100
    PPRAHAHSLV GKQCSELGVC AVSVGPKDMT AQFNNLGVLH VTKKNMMEIM 150
    IQKLQRQRLR SKPQGLTEAE RRELEQEAKE LKKVMDLSIV RLRFSAFLRA 200
    SDGSFSLPLK PVISQPIHDS KSPGASNLKI SRMDKTAGSV RGGDEVYLLC 250
    DKVQKDDIEV RFYEDDENGW QAFGDFSPTD VHKQYAIVFR TPPYHKMKIE 300
    RPVTVFLQLK RKRGGDVSDS KQFTYYPLVE DKEEVQRKRR KALPTFSQPF 350
    GGGSHMGGGS GGSAGGYGGA GGGGSLGFFS SSLAYNPYQS GAAPMGYYPG 400
    GGGGAQMAGS RRDTDAGEGA EEPRTPPEAP QGEPQALDTL QRAREYNARL 450
    FGLAQRSARA LLDYGVTADA RALLAGQRHL LMAQDENGDT PLHLAIIHGQ 500
    TGVIEQIAHV IYHAQYLGVI NLTNHLHQTP LHLAVITGQT RVVSFLLQVG 550
    ADPTLLDRHG DSALHLALRA GAAAPELLQA LLRSGAHAVP QILHMPDFEG 600
    LYPVHLAVHA RSPECLDLLV DCGAEVEAPE RQGGRTALHL ATEMEELGLV 650
    THLVTKLHAN VNARTFAGNT PLHLAAGLGS PTLTRLLLKA GTDIHAENEE 700
    PLCPLPSPST SGSDSDSEGP ERDTQRNFRG HTPLDLTCST KGQGCPWGMQ 750
    PCRTWSNCWM VPKPRAAGQS WQSDWG 776
    Length:776
    Mass (Da):84,205
    Last modified:July 19, 2005 - v1
    Checksum:i447A403AAE006274
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ020182 mRNA. Translation: AAY44750.1.
    UniGeneiMm.102365.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ020182 mRNA. Translation: AAY44750.1 .
    UniGenei Mm.102365.

    3D structure databases

    ProteinModelPortali Q4U108.
    SMRi Q4U108. Positions 37-327.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1099800. Nfkb2.

    Phylogenomic databases

    HOVERGENi HBG052613.
    InParanoidi Q4U108.

    Miscellaneous databases

    ChiTaRSi NFKB2. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q4U108.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR000451. NF_Rel_Dor.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    PF12796. Ank_2. 2 hits.
    PF00554. RHD. 1 hit.
    [Graphical view ]
    PRINTSi PR00057. NFKBTNSCPFCT.
    SMARTi SM00248. ANK. 6 hits.
    SM00429. IPT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    PS01204. REL_1. 1 hit.
    PS50254. REL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CD14-dependent modulation of NF-kappaB alternative splicing in the lung after burn injury."
      Phan H.H., Cho K., Sainz-Lyon K.S., Shin S., Greenhalgh D.G.
      Gene 371:121-129(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B6.129S-Cd14Imported.

    Entry informationi

    Entry nameiQ4U108_MOUSE
    AccessioniPrimary (citable) accession number: Q4U108
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)