Reviewed, UniProtKB/Swiss-Prot Q4TVR5 (DUSTY_BOVIN)

Names and origin

Protein names

Recommended name:
    Dual serine/threonine and tyrosine protein kinase
    EC=2.7.12.1
Alternative name(s):
    Dusty protein kinase
      Short name=Dusty PK
    Receptor-interacting serine/threonine-protein kinase 5

Gene names

Name:	DSTYK
Synonyms:	RIPK5

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	928 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May induce both caspase-dependent apoptosis and caspase-independent cell death By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 928	928	Dual serine/threonine and tyrosine protein kinase		PRO_0000233116
Regions
	Domain	651 – 905	255	Protein kinase
	Nucleotide binding	657 – 665	9	ATP By similarity
	Coiled coil	394 – 430	37	Potential
	Compositional bias	15 – 22	8	Poly-Gly
Sites
	Active site	776	1	Proton acceptor By similarity
	Binding site	680	1	ATP By similarity
Amino acid modifications
	Modified residue	927	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4TVR5-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 21AE8DAF0D53DFE8	FASTA	928	104,804
	10 20 30 40 50 60 MEGDGVPWGS EPESGPGPGG GGVIRELCRG FGRYRRYLGR LRQNLRDTQK FFRDLRGSQP 70 80 90 100 110 120 RGCPSSPAEG GEAGRGPAGD VAATGLPAGQ LSCISFPPKE EKRLQQMVDC LPCILILGQD 130 140 150 160 170 180 CSVKCQLLNL LLGVQVLPTN KLGGENCKLR RLRFTYGTQT RVSLALPDRY ELVHTLAAHQ 190 200 210 220 230 240 GTWETVPEED LEAREDSEDA ARVLAELEVT MRHALLQEVD IVVAPCQGLR PTVDVLSDLV 250 260 270 280 290 300 NDFLPVITYA LHKDELSERD EQELQEIRKY FSFPIFFFKV PKLGSEIIDS STERMESERS 310 320 330 340 350 360 PLHRQLTDLG YLSSSLCNCG APGQDTKAQS MLVEQSEKLR HLNTFSHQVL QTRLVDAAKA 370 380 390 400 410 420 LNLVHCRCLD IFINQAFDMQ RDLQITPKRL EYTRKKENEL YESLMNIANR KQEEMKDMIV 430 440 450 460 470 480 ETLNTMKEEL LDDAANMEFK DVIVPENGEP VGTREIKCCI RQIQELIISR LNQAVANKLI 490 500 510 520 530 540 SSVDYLRESF VGTLERCLQS LEKSQDVSVH ITSNYLKQIL NAAYHVEVTF HSGSSVTRML 550 560 570 580 590 600 WEQIKQIIQR ITWVSPPAIT LEWKRKVAQE AIESLSASKL AKSICSQFRT RLNSSHEAFA 610 620 630 640 650 660 ASLRQLEAGH SGRLEKTEDL WLKVRKDHAP RLARLSLESR SLQDVLLHRK PKLGQELGRG 670 680 690 700 710 720 QYGVVYLCDS WGGHFPCALK SVVPPDEKHW NDLALEFHYM RSLPKHERLV DLHGSVIDYS 730 740 750 760 770 780 YGGGSSIAVL LIMERLHRDL YTGLKAGLAL ETRLQIALDV VEGIRFLHSQ GLVHRDVKLK 790 800 810 820 830 840 NVLLDKQNRA KITDLGFCKP EAMMSGSIVG TPIHMAPELF TGKYDNSVDV YAFGILFWYI 850 860 870 880 890 900 CSGSVKLPEA FERCASKDHL WNNVRRGARP ERLPVFDEEC WQLMEACWDG DPSQRPLLGI 910 920 VQPMLQGIMD RLCKSHSERP NRGLDDST

References

[1]

"Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain." Peng J., Dong W., Chen Y., Mo R., Cheng J.-F., Hui C.-C., Mohandas N., Huang C.-H. Biochim. Biophys. Acta 1759:562-572(2006) [PubMed: 17123648] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ054504 mRNA. Translation: AAY46409.1.
IPI	IPI00694432.
RefSeq	NP_001019995.1.
UniGene	Bt.40447
3D structure databases
SMR	Q4TVR5. Positions 650-908.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000022108; ENSBTAP00000022108; ENSBTAG00000016618; Bos taurus. [Genome view]
GeneID	534684.
KEGG	bta:534684.
Organism-specific databases
CTD	534684.
Phylogenomic databases
eggNOG	maNOG10451.
HOVERGEN	Q4TVR5.
InParanoid	Q4TVR5.
OMA	AGQLSCI.
OrthoDB	EOG9T7BPV.
Enzyme and pathway databases
BRENDA	2.7.11.1. 251.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUSTY_BOVIN

Accession

Primary (citable) accession number: Q4TVR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	July 19, 2005
Last modified:	February 9, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)