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Protein

C-type mannose receptor 2

Gene

Mrc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices (By similarity). May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs) secreted by hepatic stellate cells. May mediate endocytosis of partially degraded collagens and glycoproteins produced in the extracellular matrix by MMPs.By similarity1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • collagen binding Source: RGD
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium, Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type mannose receptor 2
Alternative name(s):
Endocytic receptor 180
Macrophage mannose receptor 2
CD_antigen: CD280
Gene namesi
Name:Mrc2
Synonyms:Endo180
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1559436. Mrc2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 1413ExtracellularSequence analysisAdd BLAST1383
Transmembranei1414 – 1434HelicalSequence analysisAdd BLAST21
Topological domaini1435 – 1480CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000004608031 – 1480C-type mannose receptor 2Add BLAST1450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi92 ↔ 111By similarity
Glycosylationi101N-linked (GlcNAc...)Sequence analysis1
Glycosylationi139N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi186 ↔ 212By similarity
Disulfide bondi200 ↔ 227By similarity
Disulfide bondi265 ↔ 358By similarity
Disulfide bondi334 ↔ 350By similarity
Glycosylationi363N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi409 ↔ 503By similarity
Disulfide bondi480 ↔ 495By similarity
Disulfide bondi617 ↔ 634By similarity
Disulfide bondi703 ↔ 807By similarity
Disulfide bondi784 ↔ 799By similarity
Disulfide bondi852 ↔ 949By similarity
Disulfide bondi926 ↔ 941By similarity
Glycosylationi1028N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1077 ↔ 1097By similarity
Cross-linki1141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Disulfide bondi1219 ↔ 1233By similarity
Glycosylationi1348N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1367 ↔ 1382By similarity

Post-translational modificationi

N-glycosylated.1 Publication
Phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ4TU93.
PRIDEiQ4TU93.

PTM databases

iPTMnetiQ4TU93.
PhosphoSitePlusiQ4TU93.

Interactioni

Subunit structurei

Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V (By similarity). Interacts with C-terminal region of type I collagen/COL1A1.By similarity1 Publication

GO - Molecular functioni

  • collagen binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052010.

Structurei

3D structure databases

ProteinModelPortaliQ4TU93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 166Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST127
Domaini181 – 229Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST49
Domaini243 – 359C-type lectin 1PROSITE-ProRule annotationAdd BLAST117
Domaini388 – 504C-type lectin 2PROSITE-ProRule annotationAdd BLAST117
Domaini527 – 643C-type lectin 3PROSITE-ProRule annotationAdd BLAST117
Domaini677 – 808C-type lectin 4PROSITE-ProRule annotationAdd BLAST132
Domaini831 – 950C-type lectin 5PROSITE-ProRule annotationAdd BLAST120
Domaini978 – 1106C-type lectin 6PROSITE-ProRule annotationAdd BLAST129
Domaini1131 – 1242C-type lectin 7PROSITE-ProRule annotationAdd BLAST112
Domaini1271 – 1391C-type lectin 8PROSITE-ProRule annotationAdd BLAST121

Domaini

C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner (By similarity).By similarity
Fibronectin type-II domain mediates collagen-binding.By similarity
Ricin B-type lectin domain contacts with the second C-type lectin domain.

Sequence similaritiesi

Contains 8 C-type lectin domains.PROSITE-ProRule annotation
Contains 1 fibronectin type-II domain.PROSITE-ProRule annotation
Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS43. Eukaryota.
ENOG410XQ89. LUCA.
HOGENOMiHOG000231191.
HOVERGENiHBG053606.
InParanoidiQ4TU93.
KOiK06560.
PhylomeDBiQ4TU93.

Family and domain databases

CDDicd00062. FN2. 1 hit.
Gene3Di2.10.10.10. 1 hit.
3.10.100.10. 8 hits.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00040. fn2. 1 hit.
PF00059. Lectin_C. 8 hits.
[Graphical view]
SMARTiSM00034. CLECT. 8 hits.
SM00059. FN2. 1 hit.
SM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF56436. SSF56436. 8 hits.
SSF57440. SSF57440. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 3 hits.
PS50041. C_TYPE_LECTIN_2. 8 hits.
PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4TU93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPIRPALAP WPRHLLRCVL LLGGLRLGHP ADSAAALLEP DVFLIFSQGM
60 70 80 90 100
QGCLEAQGVQ VRVIPVCNAS LPAQRWKWVS RNRLFNLGAM QCLGTGWPAT
110 120 130 140 150
NTTVSLGMYE CDREALSLRW QCRTLGDQLS LLLGARANNA SKPGTLERGD
160 170 180 190 200
QTRSGHWNIY GSEEDLCARP YYEVYTIQGN SHGKPCTIPF KYDNQWFHGC
210 220 230 240 250
TSTGREDGHL WCATTQDYGK DERWGFCPIK SNDCETFWDK DQLTDSCYQF
260 270 280 290 300
NFQSTLSWRE AWASCEQQGA DLLSITEIHE QTYINGLLTG YSSTLWIGLN
310 320 330 340 350
DLDTSGGWQW SDNSPLKYLN WESDQPDNPG EENCGVIRTE SSGGWQNHDC
360 370 380 390 400
SIALPYVCKK KPNATAEPIQ PDRWANVKVE CDPSWQPFQG HCYRLQAEKR
410 420 430 440 450
SWQESKRACL RGGGDLLSIH SMTELEFITK QIKQEVEELW IGLNDLKLQM
460 470 480 490 500
NFEWSDGSLV SFTHWHPFEP NNFRDSLEDC VTIWGPEGRW NDSPCNQSLP
510 520 530 540 550
SICKKAGRLS QGTAEEDHGC RKGWTWHSPS CYWLGEDQVI YSDARRLCTD
560 570 580 590 600
HGSQLVTITN RFEQAFVSSL IYNWEGEYFW TALQDLNSTG SFRWLSGDEV
610 620 630 640 650
MYTHWNRDQP GYRRGGCVAL ATGSAMGLWE VKNCTSFRAR YICRQSLGTP
660 670 680 690 700
VTPELPGPDP TPSLTGSCPQ GWVSDPKLRH CYKVFSSERL QEKKSWIEAL
710 720 730 740 750
GVCRELGAQL LSLASYEEEH FVANMLNKIF GESEPENHEQ HWFWIGLNRR
760 770 780 790 800
DPREGHSWRW SDGLGFSYHN FARSQHDDDN IRGCAVLDLA SLQWVAMQCQ
810 820 830 840 850
TQLDWICKIP RGVDVREPDI GRQGRLEWVR FQEAEYKFFE HHSSWAQAQR
860 870 880 890 900
ICTWFQAELT SVHSQAELDF LGQNMQKLSS DQEQHWWIGL HTSESDGRFR
910 920 930 940 950
WSDGSVINFV SWAPGKPRPI GKDKKCVYMT ARQEDWGDQR CHTALPYICK
960 970 980 990 1000
RSNSSGETRP HDLPPSTLGG CPSGWNQFLN KCFRIQGQDP QDRVKWSEAQ
1010 1020 1030 1040 1050
FSCEQQEAQL VTIANPLEQA YITASLPNVT FDLWIGLHGS QRDFQWIEQE
1060 1070 1080 1090 1100
PLLYTNWAPG EPSGPSPAPS GTKPTSCAVI LHSPSAHFTG RWDDRSCTEE
1110 1120 1130 1140 1150
THGFICQKGT DPSLSPSPAA ALPAPGTELS YLNRTFRLLQ KPLRWKDALL
1160 1170 1180 1190 1200
LCESRNASLA HVPDPYTQAF LTQAARGLQA PLWIGLASEE GSRRYSWLSE
1210 1220 1230 1240 1250
EPLNYASWQD GEPQHTGGCA YVDVDGTWRT TSCDTKLQGA VCGVSRGPPP
1260 1270 1280 1290 1300
PRISYRGSCP QGLADSSWIP FREHCYSFHT ELLLGHKEAL QRCQRAGGTV
1310 1320 1330 1340 1350
LSILDEMENV FVWEHLQTAE TQSRGAWLGM NFNPKGGMLV WQDNTAVNYS
1360 1370 1380 1390 1400
NWGPPGLGPS MLSHNSCYWI QSSSGLWRPG ACTNVTMGVV CKLPRVEENG
1410 1420 1430 1440 1450
FLPSAALPEN PVALVVVLTA AVLLLLALLT GALILYRRRQ SAERGSFEGA
1460 1470 1480
RYSRSSRSGP AEATEKNILV SDMEMNEQQE
Length:1,480
Mass (Da):167,022
Last modified:July 19, 2005 - v1
Checksum:i7E0E5C9542C95072
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ058624 mRNA. Translation: AAY53886.1.
RefSeqiNP_001019858.1. NM_001024687.1.
UniGeneiRn.213511.

Genome annotation databases

GeneIDi498011.
KEGGirno:498011.
UCSCiRGD:1559436. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ058624 mRNA. Translation: AAY53886.1.
RefSeqiNP_001019858.1. NM_001024687.1.
UniGeneiRn.213511.

3D structure databases

ProteinModelPortaliQ4TU93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052010.

PTM databases

iPTMnetiQ4TU93.
PhosphoSitePlusiQ4TU93.

Proteomic databases

PaxDbiQ4TU93.
PRIDEiQ4TU93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi498011.
KEGGirno:498011.
UCSCiRGD:1559436. rat.

Organism-specific databases

CTDi9902.
RGDi1559436. Mrc2.

Phylogenomic databases

eggNOGiENOG410IS43. Eukaryota.
ENOG410XQ89. LUCA.
HOGENOMiHOG000231191.
HOVERGENiHBG053606.
InParanoidiQ4TU93.
KOiK06560.
PhylomeDBiQ4TU93.

Miscellaneous databases

PROiQ4TU93.

Family and domain databases

CDDicd00062. FN2. 1 hit.
Gene3Di2.10.10.10. 1 hit.
3.10.100.10. 8 hits.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00040. fn2. 1 hit.
PF00059. Lectin_C. 8 hits.
[Graphical view]
SMARTiSM00034. CLECT. 8 hits.
SM00059. FN2. 1 hit.
SM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF56436. SSF56436. 8 hits.
SSF57440. SSF57440. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 3 hits.
PS50041. C_TYPE_LECTIN_2. 8 hits.
PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRC2_RAT
AccessioniPrimary (citable) accession number: Q4TU93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: July 19, 2005
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.