Q4SGW1 (Q4SGW1_TETNG) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Proteasome subunit alpha type RuleBase RU000551
EC=3.4.25.1 RuleBase RU000551

Gene names

ORF Names:

GSTENG00018444001 EMBL CAG00121.1

Organism

Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)

Taxonomic identifier

99883 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Tetraodon

Protein attributes

Sequence length	246 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity. RuleBase RU000551
Catalytic activity	Cleavage of peptide bonds with very broad specificity. RuleBase RU000551
Subunit structure	The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits By similarity. RuleBase RU000551
Subcellular location	Cytoplasm. Nucleus By similarity RuleBase RU000551.
Sequence similarities	Belongs to the peptidase T1A family. RuleBase RU000551

Ontologies

Keywords
Cellular component	Cytoplasm RuleBase RU000551 Nucleus SAAS SAAS000426 RuleBase RU000551 Proteasome RuleBase RU000551
Molecular function	Hydrolase Protease Threonine protease RuleBase RU000551
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell proteasome core complex, alpha-subunit complex Inferred from electronic annotation. Source: InterPro
Molecular function	threonine-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	246	1	EMBL CAG00121.1

Sequences

	Sequence		Length	Mass (Da)
	Q4SGW1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: FDABB40812257E43	FASTA	246	27,436
	10 20 30 40 50 60 MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AINQGGLTSV AVRGKDCAVV VTQKKVPDKL 70 80 90 100 110 120 LDASTVTHLF RITDNIGCVM SGMTADSRSQ VQRARYEAAN WQYKYGYEIP VDMLCKRIAD 130 140 150 160 170 180 ISQVYTQNAE MRPLGCCMIV IGIDEEYGPQ VYKCDPAGYY CGFKATAAGV KQTEATSFLE 190 200 210 220 230 240 KKVKKKLDWT FEQTVETAIS CLSTVLSIDF KPSELEVGVI TTQDPKFRIL TETEVDTHLM SLAERD

References

[1]

"Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype." Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C., Salanoubat M. , Levy M., Boudet N., Castellano S., Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H. Nature 431:946-957(2004) [PubMed: 15496914] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CAAE01014590 Genomic DNA. Translation: CAG00121.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q4SGW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSTNIT00000012781; ENSTNIP00000012590; ENSTNIG00000009709.
NMPDR	fig|99883.3.peg.20513.
Phylogenomic databases
eggNOG	fiNOG09004.
HOGENOM	HBG724153.
HOVERGEN	HBG107363.
OMA	GKDCAVV.
OrthoDB	EOG4BP1CH.
PhylomeDB	Q4SGW1.
Family and domain databases
InterPro	IPR000426. Proteasome_asu_N. IPR023332. Proteasome_suA-type. IPR001353. Proteasome_sua/b. [Graphical view]
Pfam	PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. [Graphical view]
SMART	SM00948. Proteasome_A_N. 1 hit. [Graphical view]
PROSITE	PS00388. PROTEASOME_A_1. 1 hit. PS51475. PROTEASOME_A_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q4SGW1_TETNG

Accession

Primary (citable) accession number: Q4SGW1

Entry history

Integrated into UniProtKB/TrEMBL:	July 19, 2005
Last sequence update:	July 19, 2005
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)