Q4SFA0 (HDAC3_TETNG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone deacetylase 3
Short name=HD3
EC=3.5.1.98

Gene names

Name:	hdac3
ORF Names:	GSTENG00019185001

Organism

Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)

Taxonomic identifier

99883 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Tetraodon

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone deacetylase family. HD type 1 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K9 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H4-K16 specific) Inferred from electronic annotation. Source: EC histone deacetylase activity (H3-K16 specific) Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	Histone deacetylase 3		PRO_0000352679
Regions
	Region	3 – 316	314	Histone deacetylase
Sites
	Active site	135	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4SFA0 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 8B6B3AFDCAE53887	FASTA	428	49,144
	10 20 30 40 50 60 MTNRTSYFYD PDVGNFHYGA GHPMKPHRLS LTHSLVLHYG LYKKMMVFKP YKASQHDMCR 70 80 90 100 110 120 FHSEDYIDFL QKVSPNNMQG FTKSLNTFNV GDDCPVFPGL FEFCSRYTGA SLQGATQLNH 130 140 150 160 170 180 KICDIAINWA GGLHHAKKFE ASGFCYVNDI VISILELLKY HPRVLYIDID IHHGDGVQEA 190 200 210 220 230 240 FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYRQLFQPVI 250 260 270 280 290 300 KQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EFVKSFKIPL LVLGGGGYTV 310 320 330 340 350 360 RNVARCWTFE TSLLLEESIS DELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLEQIRQ 370 380 390 400 410 420 TVFENLKMLN HAPSVQIHDV PSDMLNYERN DEPDPDERGA EENYTRPEAA NEFYDGDHDN DKESDVEI

References

[1]

"Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype." Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C., Salanoubat M. , Levy M., Boudet N., Castellano S., Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H. Nature 431:946-957(2004) [PubMed: 15496914] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CAAE01014606 Genomic DNA. Translation: CAG00682.1.
3D structure databases
HSSP	HSSP built from PDB template 1W22 based on UniProtKB Q9BY41.
ProteinModelPortal	Q4SFA0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSTNIT00000013213; ENSTNIP00000013021; ENSTNIG00000010123.
NMPDR	fig|99883.3.peg.10298.
Phylogenomic databases
eggNOG	fiNOG11353.
HOVERGEN	HBG057112.
PhylomeDB	Q4SFA0.
Family and domain databases
InterPro	IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. IPR023801. His_deacetylse_dom. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHER	PTHR10625. His_deacetylse. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037913. His_deacetylse_1. 1 hit.
PRINTS	PR01270. HDASUPER. PR01271. HISDACETLASE.
ProtoNet	Search...

Entry information

Entry name

HDAC3_TETNG

Accession

Primary (citable) accession number: Q4SFA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	July 19, 2005
Last modified:	October 19, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program