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Q4SFA0 (HDAC3_TETNG) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the histone deacetylase family. HD type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 428428Histone deacetylase 3
PRO_0000352679

Regions

Region3 – 316314Histone deacetylase

Sites

Active site1351 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4SFA0 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 8B6B3AFDCAE53887

FASTA42849,144
        10         20         30         40         50         60 
MTNRTSYFYD PDVGNFHYGA GHPMKPHRLS LTHSLVLHYG LYKKMMVFKP YKASQHDMCR 

        70         80         90        100        110        120 
FHSEDYIDFL QKVSPNNMQG FTKSLNTFNV GDDCPVFPGL FEFCSRYTGA SLQGATQLNH 

       130        140        150        160        170        180 
KICDIAINWA GGLHHAKKFE ASGFCYVNDI VISILELLKY HPRVLYIDID IHHGDGVQEA 

       190        200        210        220        230        240 
FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYRQLFQPVI 

       250        260        270        280        290        300 
KQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EFVKSFKIPL LVLGGGGYTV 

       310        320        330        340        350        360 
RNVARCWTFE TSLLLEESIS DELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLEQIRQ 

       370        380        390        400        410        420 
TVFENLKMLN HAPSVQIHDV PSDMLNYERN DEPDPDERGA EENYTRPEAA NEFYDGDHDN 


DKESDVEI 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CAAE01014606 Genomic DNA. Translation: CAG00682.1.

3D structure databases

ProteinModelPortalQ4SFA0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99883.ENSTNIP00000013021.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0123.
HOVERGENHBG057112.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Entry information

Entry nameHDAC3_TETNG
AccessionPrimary (citable) accession number: Q4SFA0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families