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Q4SFA0

- HDAC3_TETNG

UniProt

Q4SFA0 - HDAC3_TETNG

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Protein
Histone deacetylase 3
Gene
hdac3, GSTENG00019185001
Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351 By similarity

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 3 (EC:3.5.1.98)
Short name:
HD3
Gene namesi
Name:hdac3
ORF Names:GSTENG00019185001
OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Taxonomic identifieri99883 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
ProteomesiUP000007303: Unplaced

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Histone deacetylase 3
PRO_0000352679Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi99883.ENSTNIP00000013021.

Structurei

3D structure databases

ProteinModelPortaliQ4SFA0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni3 – 316314Histone deacetylase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
HOVERGENiHBG057112.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q4SFA0-1 [UniParc]FASTAAdd to Basket

« Hide

MTNRTSYFYD PDVGNFHYGA GHPMKPHRLS LTHSLVLHYG LYKKMMVFKP    50
YKASQHDMCR FHSEDYIDFL QKVSPNNMQG FTKSLNTFNV GDDCPVFPGL 100
FEFCSRYTGA SLQGATQLNH KICDIAINWA GGLHHAKKFE ASGFCYVNDI 150
VISILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF 200
PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYRQLFQPVI KQVVDFYQPT 250
CIVLQCGADS LGCDRLGCFN LSIRGHGECV EFVKSFKIPL LVLGGGGYTV 300
RNVARCWTFE TSLLLEESIS DELPYSEYFE YFAPDFTLHP DVSTRIENQN 350
SRQYLEQIRQ TVFENLKMLN HAPSVQIHDV PSDMLNYERN DEPDPDERGA 400
EENYTRPEAA NEFYDGDHDN DKESDVEI 428
Length:428
Mass (Da):49,144
Last modified:July 19, 2005 - v1
Checksum:i8B6B3AFDCAE53887
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CAAE01014606 Genomic DNA. Translation: CAG00682.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CAAE01014606 Genomic DNA. Translation: CAG00682.1 .

3D structure databases

ProteinModelPortali Q4SFA0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99883.ENSTNIP00000013021.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0123.
HOVERGENi HBG057112.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype."
    Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C., Salanoubat M.
    , Levy M., Boudet N., Castellano S., Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.
    Nature 431:946-957(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiHDAC3_TETNG
AccessioniPrimary (citable) accession number: Q4SFA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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