ID   HNMT_TETNG              Reviewed;         291 AA.
AC   Q4SBY6;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 18.
DE   RecName: Full=Histamine N-methyltransferase;
DE            Short=HMT;
DE            EC=2.1.1.8;
GN   Name=hnmt; ORFNames=GSTENG00020755001;
OS   Tetraodon nigroviridis (Green puffer).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;
OC   Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes;
OC   Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- FUNCTION: Inactivates histamine by N-methylation. Plays an
CC       important role in degrading histamine and in regulating the airway
CC       response to histamine (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + histamine = S-
CC       adenosyl-L-homocysteine + N(tau)-methylhistamine.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. HNMT
CC       family.
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DR   EMBL; CAAE01014661; CAG01846.1; -; Genomic_DNA.
DR   NMPDR; fig|99883.3.peg.15722; -.
DR   HOVERGEN; Q4SBY6; -.
DR   OMA; Q4SBY6; YDLLSTM.
DR   BRENDA; 2.1.1.8; 295302.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046539; F:histamine N-methyltransferase activity; IEA:EC.
DR   InterPro; IPR016673; Histamine_N-methyltransferase.
DR   PIRSF; PIRSF016616; HHMT; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    291       Histamine N-methyltransferase.
FT                                /FTId=PRO_0000271425.
FT   BINDING      28     28       Substrate (By similarity).
FT   BINDING      60     60       S-adenosyl-L-methionine; via carbonyl
FT                                oxygen (By similarity).
FT   BINDING      89     89       S-adenosyl-L-methionine (By similarity).
FT   BINDING      94     94       S-adenosyl-L-methionine (By similarity).
FT   BINDING     142    142       S-adenosyl-L-methionine; via carbonyl
FT                                oxygen (By similarity).
FT   BINDING     283    283       Substrate (By similarity).
SQ   SEQUENCE   291 AA;  32938 MW;  8550AE3B0DA4ADB1 CRC64;
     MASAMRSLIE DDSRYLKSFK LFLERSTEHQ CVQEFIHNVL PDILGSVGKG KTHLNVIGVG
     SGAGEVDLEI LSELHSRHPG ASVDNEVVEP SAQQLQDYKA LVLQKKDLDY ISFNWNKMTA
     TEFEERWRAN KMSKEADFIH MIQMLYYVKD PEATTSFFQS LLSKTGKLLI ILVSGNSGWG
     KLWKTYKNQF CNPEISQCVT TADIQSFLDS KGARYQSFEL PSQMDITECF TQGDEKGELL
     LDFLTEVLEF SKTASPELRA EVMELLRHPD CSVESNGRVM FNNNLGVIVL D
//