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Q4SBY6 (HNMT_TETNG) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.

Catalytic activity

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistamine N-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291Histamine N-methyltransferase
PRO_0000271425

Sites

Binding site281Substrate By similarity
Binding site601S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site891S-adenosyl-L-methionine By similarity
Binding site941S-adenosyl-L-methionine By similarity
Binding site1421S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site2831Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4SBY6 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 8550AE3B0DA4ADB1

FASTA29132,938
        10         20         30         40         50         60 
MASAMRSLIE DDSRYLKSFK LFLERSTEHQ CVQEFIHNVL PDILGSVGKG KTHLNVIGVG 

        70         80         90        100        110        120 
SGAGEVDLEI LSELHSRHPG ASVDNEVVEP SAQQLQDYKA LVLQKKDLDY ISFNWNKMTA 

       130        140        150        160        170        180 
TEFEERWRAN KMSKEADFIH MIQMLYYVKD PEATTSFFQS LLSKTGKLLI ILVSGNSGWG 

       190        200        210        220        230        240 
KLWKTYKNQF CNPEISQCVT TADIQSFLDS KGARYQSFEL PSQMDITECF TQGDEKGELL 

       250        260        270        280        290 
LDFLTEVLEF SKTASPELRA EVMELLRHPD CSVESNGRVM FNNNLGVIVL D 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CAAE01014661 Genomic DNA. Translation: CAG01846.1.

3D structure databases

ProteinModelPortalQ4SBY6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99883.ENSTNIP00000013918.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG39680.
HOVERGENHBG051914.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PIRSFPIRSF016616. HHMT. 1 hit.
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51597. SAM_HNMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHNMT_TETNG
AccessionPrimary (citable) accession number: Q4SBY6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families