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Reviewed, UniProtKB/Swiss-Prot Q4SBY6 (HNMT_TETNG)

Last modified June 16, 2009. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Histamine N-methyltransferase
      Short name=HMT
    EC=2.1.1.8
Gene names
Name: hnmt
ORF Names: GSTENG00020755001
OrganismTetraodon nigroviridis (Green puffer)
Taxonomic identifier99883 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaAcanthopterygiiPercomorphaTetraodontiformesTetradontoideaTetraodontidaeTetraodon

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.

Catalytic activity

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the methyltransferase superfamily. HNMT family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionhistamine N-methyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291Histamine N-methyltransferase
PRO_0000271425

Sites

Binding site281Substrate By similarity
Binding site601S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site891S-adenosyl-L-methionine By similarity
Binding site941S-adenosyl-L-methionine By similarity
Binding site1421S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site2831Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4SBY6-1 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 8550AE3B0DA4ADB1

FASTA29132,938
        10         20         30         40         50         60 
MASAMRSLIE DDSRYLKSFK LFLERSTEHQ CVQEFIHNVL PDILGSVGKG KTHLNVIGVG 

        70         80         90        100        110        120 
SGAGEVDLEI LSELHSRHPG ASVDNEVVEP SAQQLQDYKA LVLQKKDLDY ISFNWNKMTA 

       130        140        150        160        170        180 
TEFEERWRAN KMSKEADFIH MIQMLYYVKD PEATTSFFQS LLSKTGKLLI ILVSGNSGWG 

       190        200        210        220        230        240 
KLWKTYKNQF CNPEISQCVT TADIQSFLDS KGARYQSFEL PSQMDITECF TQGDEKGELL 

       250        260        270        280        290 
LDFLTEVLEF SKTASPELRA EVMELLRHPD CSVESNGRVM FNNNLGVIVL D 

« Hide

Cross-references

Sequence databases

CAAE01014661 Genomic DNA. Translation: CAG01846.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

NMPDRfig|99883.3.peg.15722.

Phylogenomic databases

HOVERGENQ4SBY6.
OMAQ4SBY6. YDLLSTM.

Enzyme and pathway databases

BRENDA2.1.1.8. 295302.

Family and domain databases

InterProIPR016673. Histamine_N-methyltransferase.
[Graphical view]
PIRSFPIRSF016616. HHMT. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHNMT_TETNG
AccessionPrimary (citable) accession number: Q4SBY6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 19, 2005
Last modified: June 16, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents