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Q4S5X1 (CISY_TETNG) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase, mitochondrial

EC=2.3.3.1
Alternative name(s):
Citrate (Si)-synthase
Gene names
Name:cs
ORF Names:GSTENG00023547001
OrganismTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) [Reference proteome]
Taxonomic identifier99883 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3030Mitochondrion By similarity
Chain31 – 469439Citrate synthase, mitochondrial
PRO_0000253905

Sites

Active site3041 By similarity
Active site3501 By similarity
Active site4051 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4S5X1 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 980C3309C330B9FE

FASTA46952,012
        10         20         30         40         50         60 
MSFLTVNRLA SKLLNSKNAT YFLVAARNAS ASTTNLKDVL ADLIPKEQNR IKNFKQQYGK 

        70         80         90        100        110        120 
TNIGQITVDM VYGGMRGMKG LVYETSVLDP DEGIRFRGYS IPECQKLLPK AAGGQEPLPE 

       130        140        150        160        170        180 
GLFWLLVTGQ VPTEEQVNWV SKEWAKRAAL PSHVVTMLDN FPTNLHPMSQ FSAAVTALNS 

       190        200        210        220        230        240 
ESSFARAYSE GVHKSKYWEF AYEDSMDLIA KLPCIAAKIY RNLYREGSSI GAIDSGLDWS 

       250        260        270        280        290        300 
HNFTNMLGYS DAQFTELMRL YLTIHSDHEG GNVSAHTSHL VGSALSDPYL AFSAAMNGLA 

       310        320        330        340        350        360 
GPLHGLANQE VLVWLTALQK ELGGEVSDEK MRDYIWNTLK SGRVVPGYGH AVLRKTDPRY 

       370        380        390        400        410        420 
SCQREFAMKH LPNDPMFKLV AQLYKIVPDV LLEQGKAKNP WPNVDAHSGV LLQYYGMTEM 

       430        440        450        460 
NYYTVLFGVS RALGVLSQLV WSRALGFPLE RPKSMSTDGL MSLVGAKSG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CAAE01014729 Genomic DNA. Translation: CAG03961.1.

3D structure databases

ProteinModelPortalQ4S5X1.
SMRQ4S5X1. Positions 31-467.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ4S5X1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSTNIT00000015697; ENSTNIP00000015491; ENSTNIG00000012522.

Phylogenomic databases

eggNOGCOG0372.
GeneTreeENSGT00390000006813.
HOVERGENHBG005336.
OMAELIYEDC.
OrthoDBEOG73BVCB.
TreeFamTF300398.

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01793. cit_synth_euk. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_TETNG
AccessionPrimary (citable) accession number: Q4S5X1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways