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Q4S5X1

- CISY_TETNG

UniProt

Q4S5X1 - CISY_TETNG

Protein

Citrate synthase, mitochondrial

Gene

cs

Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei304 – 3041PROSITE-ProRule annotation
    Active sitei350 – 3501PROSITE-ProRule annotation
    Active sitei405 – 4051PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB
    2. cellular carbohydrate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase, mitochondrial (EC:2.3.3.1)
    Alternative name(s):
    Citrate (Si)-synthase
    Gene namesi
    Name:cs
    ORF Names:GSTENG00023547001
    OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
    Taxonomic identifieri99883 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
    ProteomesiUP000007303: Unplaced

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3030MitochondrionBy similarityAdd
    BLAST
    Chaini31 – 469439Citrate synthase, mitochondrialPRO_0000253905Add
    BLAST

    Proteomic databases

    PRIDEiQ4S5X1.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ4S5X1.
    SMRiQ4S5X1. Positions 31-467.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0372.
    GeneTreeiENSGT00390000006813.
    HOVERGENiHBG005336.
    OMAiELIYEDC.
    OrthoDBiEOG73BVCB.
    TreeFamiTF300398.

    Family and domain databases

    Gene3Di1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4S5X1-1 [UniParc]FASTAAdd to Basket

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    MSFLTVNRLA SKLLNSKNAT YFLVAARNAS ASTTNLKDVL ADLIPKEQNR    50
    IKNFKQQYGK TNIGQITVDM VYGGMRGMKG LVYETSVLDP DEGIRFRGYS 100
    IPECQKLLPK AAGGQEPLPE GLFWLLVTGQ VPTEEQVNWV SKEWAKRAAL 150
    PSHVVTMLDN FPTNLHPMSQ FSAAVTALNS ESSFARAYSE GVHKSKYWEF 200
    AYEDSMDLIA KLPCIAAKIY RNLYREGSSI GAIDSGLDWS HNFTNMLGYS 250
    DAQFTELMRL YLTIHSDHEG GNVSAHTSHL VGSALSDPYL AFSAAMNGLA 300
    GPLHGLANQE VLVWLTALQK ELGGEVSDEK MRDYIWNTLK SGRVVPGYGH 350
    AVLRKTDPRY SCQREFAMKH LPNDPMFKLV AQLYKIVPDV LLEQGKAKNP 400
    WPNVDAHSGV LLQYYGMTEM NYYTVLFGVS RALGVLSQLV WSRALGFPLE 450
    RPKSMSTDGL MSLVGAKSG 469
    Length:469
    Mass (Da):52,012
    Last modified:July 19, 2005 - v1
    Checksum:i980C3309C330B9FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CAAE01014729 Genomic DNA. Translation: CAG03961.1.

    Genome annotation databases

    EnsembliENSTNIT00000015697; ENSTNIP00000015491; ENSTNIG00000012522.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CAAE01014729 Genomic DNA. Translation: CAG03961.1 .

    3D structure databases

    ProteinModelPortali Q4S5X1.
    SMRi Q4S5X1. Positions 31-467.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q4S5X1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSTNIT00000015697 ; ENSTNIP00000015491 ; ENSTNIG00000012522 .

    Phylogenomic databases

    eggNOGi COG0372.
    GeneTreei ENSGT00390000006813.
    HOVERGENi HBG005336.
    OMAi ELIYEDC.
    OrthoDBi EOG73BVCB.
    TreeFami TF300398.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .

    Family and domain databases

    Gene3Di 1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype."
      Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C., Salanoubat M.
      , Levy M., Boudet N., Castellano S., Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.
      Nature 431:946-957(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCISY_TETNG
    AccessioniPrimary (citable) accession number: Q4S5X1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3