Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4S5X1

- CISY_TETNG

UniProt

Q4S5X1 - CISY_TETNG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Citrate synthase, mitochondrial

Gene

cs

Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei304 – 3041PROSITE-ProRule annotation
Active sitei350 – 3501PROSITE-ProRule annotation
Active sitei405 – 4051PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.1)
Alternative name(s):
Citrate (Si)-synthase
Gene namesi
Name:cs
ORF Names:GSTENG00023547001
OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Taxonomic identifieri99883 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon
ProteomesiUP000007303: Unplaced

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionBy similarityAdd
BLAST
Chaini31 – 469439Citrate synthase, mitochondrialPRO_0000253905Add
BLAST

Proteomic databases

PRIDEiQ4S5X1.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ4S5X1.
SMRiQ4S5X1. Positions 31-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
GeneTreeiENSGT00390000006813.
HOVERGENiHBG005336.
InParanoidiQ4S5X1.
OMAiELIYEDC.
OrthoDBiEOG73BVCB.
TreeFamiTF300398.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4S5X1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFLTVNRLA SKLLNSKNAT YFLVAARNAS ASTTNLKDVL ADLIPKEQNR
60 70 80 90 100
IKNFKQQYGK TNIGQITVDM VYGGMRGMKG LVYETSVLDP DEGIRFRGYS
110 120 130 140 150
IPECQKLLPK AAGGQEPLPE GLFWLLVTGQ VPTEEQVNWV SKEWAKRAAL
160 170 180 190 200
PSHVVTMLDN FPTNLHPMSQ FSAAVTALNS ESSFARAYSE GVHKSKYWEF
210 220 230 240 250
AYEDSMDLIA KLPCIAAKIY RNLYREGSSI GAIDSGLDWS HNFTNMLGYS
260 270 280 290 300
DAQFTELMRL YLTIHSDHEG GNVSAHTSHL VGSALSDPYL AFSAAMNGLA
310 320 330 340 350
GPLHGLANQE VLVWLTALQK ELGGEVSDEK MRDYIWNTLK SGRVVPGYGH
360 370 380 390 400
AVLRKTDPRY SCQREFAMKH LPNDPMFKLV AQLYKIVPDV LLEQGKAKNP
410 420 430 440 450
WPNVDAHSGV LLQYYGMTEM NYYTVLFGVS RALGVLSQLV WSRALGFPLE
460
RPKSMSTDGL MSLVGAKSG
Length:469
Mass (Da):52,012
Last modified:July 19, 2005 - v1
Checksum:i980C3309C330B9FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CAAE01014729 Genomic DNA. Translation: CAG03961.1.

Genome annotation databases

EnsembliENSTNIT00000015697; ENSTNIP00000015491; ENSTNIG00000012522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CAAE01014729 Genomic DNA. Translation: CAG03961.1 .

3D structure databases

ProteinModelPortali Q4S5X1.
SMRi Q4S5X1. Positions 31-467.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q4S5X1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSTNIT00000015697 ; ENSTNIP00000015491 ; ENSTNIG00000012522 .

Phylogenomic databases

eggNOGi COG0372.
GeneTreei ENSGT00390000006813.
HOVERGENi HBG005336.
InParanoidi Q4S5X1.
OMAi ELIYEDC.
OrthoDBi EOG73BVCB.
TreeFami TF300398.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype."
    Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C., Salanoubat M.
    , Levy M., Boudet N., Castellano S., Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.
    Nature 431:946-957(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCISY_TETNG
AccessioniPrimary (citable) accession number: Q4S5X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3