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Q4RVN6 (Q4RVN6_TETNG) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
ORF Names:GSTENG00028241001 EMBL CAG07546.1
OrganismTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Taxonomic identifier99883 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Tetraodon

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding10 – 156NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding33 – 353NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000109-3
Region129 – 1313Substrate binding By similarity PIRSR PIRSR000109-2
Region187 – 1882Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1841Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1911Proton donor By similarity PIRSR PIRSR000109-1
Binding site1031NADP By similarity PIRSR PIRSR000109-3
Binding site1031Substrate By similarity PIRSR PIRSR000109-2
Binding site1921Substrate By similarity PIRSR PIRSR000109-2
Binding site2611Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2881Substrate By similarity PIRSR PIRSR000109-2
Binding site4471Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4531Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q4RVN6 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 5539BDFFDA53AFE2

FASTA48353,161
        10         20         30         40         50         60 
MAEADIALIG LAVMGQNLIM NMNDHGFVVC AYNRTVSKVQ DFLQNEAKGS KVIGAESLED 

        70         80         90        100        110        120 
MVSKLKKPRR IILLVKAGQA VDDFIDKLVP LLEAGDIIID GGNSEYRDTT RRCKSLKQKG 

       130        140        150        160        170        180 
LLFVGSGVSG GEEGARYGPS LMPGGHEEAW PHIRDIFQSI AAKVGTGEPC CDWVGDEGAG 

       190        200        210        220        230        240 
HFVKMVHNGI EYGDMQLICE AYHLMKDVLG MDHDEMAQAF DDWNKTELDS FLIEITANIL 

       250        260        270        280        290        300 
KFRDSDNTHL LPKIRDSAGQ KGTGKWTAIS ALEYGTPVTL IGEAVFARCL SSLKEERVEA 

       310        320        330        340        350        360 
SRSLSGPQGV QFGGDKAAFL EDIRKALYAS KIISYAQGFM LLRQAAKEFG WTLNYGAIAL 

       370        380        390        400        410        420 
MWRGGCIIRS VFLGKIKEAF DRDAKLQNLL LDSFFSQAVQ DCQASWRRTV STGVQHGIPM 

       430        440        450        460        470        480 
PCFTTALSFY DGYRHEKLPA NLLQAQRDYF GAHTYELLSN PGQFIHTNWT GHGGTVSSSS 


YNA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CAAE01014991 Genomic DNA. Translation: CAG07546.1.

3D structure databases

ProteinModelPortalQ4RVN6.
SMRQ4RVN6. Positions 2-474.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4RVN6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSTNIT00000018453; ENSTNIP00000018228; ENSTNIG00000015172.
NMPDRfig|99883.3.peg.24734.

Phylogenomic databases

eggNOGfiNOG13147.
HOVERGENHBG000029.
OMAMEHNEMA.
OrthoDBEOG4C2H9D.
PhylomeDBQ4RVN6.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ4RVN6_TETNG
AccessionPrimary (citable) accession number: Q4RVN6
Entry history
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: December 14, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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