Reviewed, UniProtKB/Swiss-Prot Q4RSM6 (GPX8_TETNG)

Names and origin

Protein names

Recommended name:
    Probable glutathione peroxidase 8
    EC=1.11.1.9

Gene names

Name:	gpx8
ORF Names:	GSTENG00029623001

Organism

Tetraodon nigroviridis (Green puffer)

Taxonomic identifier

99883 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Tetraodon

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the glutathione peroxidase family.
Caution	Ser-80 is present instead of the conserved Cys/Sec which is expected to be the active site residue.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Probable glutathione peroxidase 8		PRO_0000317761
Regions
	Transmembrane	21 – 40	20	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4RSM6-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 40C021CC4524175C	FASTA	210	23,918
	10 20 30 40 50 60 MEALGGYPTR SSNPKAKKLT VLLSMTVGVG CLLLLQTQLL KPRRPSDFYS FEVKDAKGRT 70 80 90 100 110 120 VSLEKYRGKA SLVVNVASRS EQTESNYRSL QELHRELGPS HFNVLAFPCA QFGETETGSS 130 140 150 160 170 180 RDSEAFAKAT YGVTFPFFSR IKIMGSEAEP AFRFLTDSVQ KVPRWNFWKF LVNPEGKVVR 190 200 210 FWRTDEPMES IRREVTALVR EIILKKRVEL

References

[1]

"Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype." Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C., Salanoubat M. , Levy M., Boudet N., Castellano S., Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H. Nature 431:946-957(2004) [PubMed: 15496914] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CAAE01014999 Genomic DNA. Translation: CAG08606.1.
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSTNIG00000011407. Tetraodon nigroviridis. [Contig view]
NMPDR	fig|99883.3.peg.21216.
Phylogenomic databases
HOVERGEN	Q4RSM6.
OMA	Q4RSM6. FHFSVLA.
Enzyme and pathway databases
BRENDA	1.11.1.9. 295302.
Family and domain databases
InterPro	IPR013376. Glut_perox_Gpx7. IPR000889. Glutathione_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
TIGRFAMs	TIGR02540. gpx7. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. False negative. PS00763. GLUTATHIONE_PEROXID_2. False negative. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX8_TETNG

Accession

Primary (citable) accession number: Q4RSM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 19, 2005
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)