ID   DUPD1_TETNG             Reviewed;         211 AA.
AC   Q4RQD3;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Dual specificity phosphatase DUPD1;
DE            EC=3.1.3.48;
DE            EC=3.1.3.16;
GN   Name=dupd1; ORFNames=GSTENG00030658001;
OS   Tetraodon nigroviridis (Green puffer).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;
OC   Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes;
OC   Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC       tyrosine + phosphate.
CC   -!- CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein +
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       Non-receptor class dual specificity subfamily.
CC   -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG09399.1; Type=Erroneous gene model prediction;
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DR   EMBL; CAAE01015006; CAG09399.1; ALT_SEQ; Genomic_DNA.
DR   HSSP; P51452; 1VHR.
DR   Ensembl; ENSTNIG00000014542; Tetraodon nigroviridis.
DR   HOVERGEN; Q4RQD3; -.
DR   BRENDA; 3.1.3.16; 295302.
DR   BRENDA; 3.1.3.48; 295302.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphata...; IEA:InterPro.
DR   GO; GO:0006470; P:protein amino acid dephosphorylation; IEA:InterPro.
DR   InterPro; IPR000387; Tyr_Pase.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR000340; Tyr_Pase_dual_specific.
DR   Pfam; PF00782; DSPc; 1.
DR   SMART; SM00195; DSPc; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Protein phosphatase.
FT   CHAIN         1    211       Dual specificity phosphatase DUPD1.
FT                                /FTId=PRO_0000295889.
FT   DOMAIN       46    194       Tyrosine-protein phosphatase.
FT   ACT_SITE    140    140       Phosphocysteine intermediate (By
FT                                similarity).
SQ   SEQUENCE   211 AA;  23780 MW;  E752CEF4B11B86FB CRC64;
     MSSGVKSKSR NPYTAVRVDP DSDYVTPGTL DLEQLFWTGP EVQYTHVNLV WPGIYIGDEK
     TALELPGLRD LGITHVLNAA EGKWNNVLTG AGYYSDANIC YYGVEADDKP TFNISQFFQP
     AAQFIHEALS QPHNNVLVHC VMGRSRSATL VLAYLMMRHS LSVVDAVEQV RQRRCILPNH
     GFLKQLRALD ITLQEERLRQ KREAPGQEKH T
//