Reviewed, UniProtKB/Swiss-Prot Q4RQD3 (DUPD1_TETNG)

Names and origin

Protein names

Recommended name:
    Dual specificity phosphatase DUPD1
    EC=3.1.3.48
    EC=3.1.3.16

Gene names

Name:	dupd1
ORF Names:	GSTENG00030658001

Organism

Tetraodon nigroviridis (Green puffer)

Taxonomic identifier

99883 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Tetraodon

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.
Sequence caution	The sequence CAG09399.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Dual specificity phosphatase DUPD1		PRO_0000295889
Regions
	Domain	46 – 194	149	Tyrosine-protein phosphatase
Sites
	Active site	140	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4RQD3-1 [UniParc]. Last modified July 24, 2007. Version 2. Checksum: E752CEF4B11B86FB	FASTA	211	23,780
	10 20 30 40 50 60 MSSGVKSKSR NPYTAVRVDP DSDYVTPGTL DLEQLFWTGP EVQYTHVNLV WPGIYIGDEK 70 80 90 100 110 120 TALELPGLRD LGITHVLNAA EGKWNNVLTG AGYYSDANIC YYGVEADDKP TFNISQFFQP 130 140 150 160 170 180 AAQFIHEALS QPHNNVLVHC VMGRSRSATL VLAYLMMRHS LSVVDAVEQV RQRRCILPNH 190 200 210 GFLKQLRALD ITLQEERLRQ KREAPGQEKH T

References

[1]

"Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype." Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N., Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C., Salanoubat M. , Levy M., Boudet N., Castellano S., Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H. Nature 431:946-957(2004) [PubMed: 15496914] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CAAE01015006 Genomic DNA. Translation: CAG09399.1. Sequence problems.
3D structure databases
HSSP	HSSP built from PDB template 1VHR based on UniProtKB P51452.
SMR	Q4RQD3. Positions 47-197.
ModBase	Search...
Genome annotation databases
Ensembl	ENSTNIT00000017786; ENSTNIP00000017566; ENSTNIG00000014542; Tetraodon nigroviridis. [Genome view]
Phylogenomic databases
eggNOG	veNOG15113.
HOGENOM	HBG279857.
HOVERGEN	Q4RQD3.
InParanoid	Q4RQD3.
Enzyme and pathway databases
BRENDA	3.1.3.16. 295302. 3.1.3.48. 295302.
Family and domain databases
InterPro	IPR000387. Dual-sp/Tyr_phosphatase. IPR020417. Dual-sp_phosphatase. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020405. Dual-sp_phosphatase_famA. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR016130. Tyr_Pase_AS. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUPD1_TETNG

Accession

Primary (citable) accession number: Q4RQD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	January 19, 2010
This is version 25 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)