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Protein

Cyclin-dependent kinase-like 3

Gene

CDKL3

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei125Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 3 (EC:2.7.11.22)
Gene namesi
Name:CDKL3
ORF Names:QtsA-10691, QtsA-11477
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858211 – 590Cyclin-dependent kinase-like 3Add BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158PhosphothreonineBy similarity1
Modified residuei160PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4R8T9.

Structurei

3D structure databases

ProteinModelPortaliQ4R8T9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST283

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 51[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG080204.
KOiK08824.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4R8T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE
60 70 80 90 100
IKFLKQFHHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK
110 120 130 140 150
RLRKYLFQIL RAIDYLHSNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL
160 170 180 190 200
AAPGDIYTDY VATRWYRAPE LVLKDTSYGK PVDIWALGCM IIEMATGNPY
210 220 230 240 250
LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP QVQHPKNARK
260 270 280 290 300
KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK
310 320 330 340 350
AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE
360 370 380 390 400
KKPKEIKVRV IKVKGGRGDI SEPKKKEYEG GLCQQDANEN VHPMSPDTKL
410 420 430 440 450
VTIEPPNPIN PSTNCNGLKE NPHCGGSMTM PPINLTNSNL MAANLNSNLF
460 470 480 490 500
HPSVRLTERA KKRRTSSQSI GQVMPNSRQE DPGPIQSQMG KGIFNERTGH
510 520 530 540 550
SDQMSNENKR KLNFSRSDRK EFHFPELPVT IQPKDTKGME VKQIKMLKRE
560 570 580 590
SKKTDSSKIP TLLNVDQNQE KQENTGNAQT ERKKNLPDVE
Length:590
Mass (Da):67,204
Last modified:July 19, 2005 - v1
Checksum:iC47879E193EE3658
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117 – 201Missing in BAE00367 (Ref. 1) CuratedAdd BLAST85
Sequence conflicti490G → E in BAE00367 (Ref. 1) Curated1
Sequence conflicti495N → S in BAE00367 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB168359 mRNA. Translation: BAE00482.1.
AB168242 mRNA. Translation: BAE00367.1.
RefSeqiNP_001270689.1. NM_001283760.1.
UniGeneiMfa.1119.

Genome annotation databases

GeneIDi101866587.
KEGGimcf:101866587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB168359 mRNA. Translation: BAE00482.1.
AB168242 mRNA. Translation: BAE00367.1.
RefSeqiNP_001270689.1. NM_001283760.1.
UniGeneiMfa.1119.

3D structure databases

ProteinModelPortaliQ4R8T9.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ4R8T9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101866587.
KEGGimcf:101866587.

Organism-specific databases

CTDi51265.

Phylogenomic databases

HOVERGENiHBG080204.
KOiK08824.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDKL3_MACFA
AccessioniPrimary (citable) accession number: Q4R8T9
Secondary accession number(s): Q4R954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 19, 2005
Last modified: October 5, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.