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Q4R8S6

- CP51A_MACFA

UniProt

Q4R8S6 - CP51A_MACFA

Protein

Lanosterol 14-alpha demethylase

Gene

CYP51A1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.By similarity

    Catalytic activityi

    A 14-alpha-methylsteroid + 3 O2 + 3 NADPH = a Delta(14)-steroid + formate + 3 NADP+ + 4 H2O.

    Cofactori

    Heme group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi449 – 4491Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: UniProtKB
    2. iron ion binding Source: InterPro
    3. sterol 14-demethylase activity Source: UniProtKB

    GO - Biological processi

    1. cholesterol biosynthetic process Source: UniProtKB-KW
    2. demethylation Source: GOC
    3. steroid biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00770; UER00754.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lanosterol 14-alpha demethylase (EC:1.14.13.70)
    Short name:
    LDM
    Alternative name(s):
    CYPLI
    Cytochrome P450 51A1
    Cytochrome P450-14DM
    Short name:
    Cytochrome P45014DM
    Cytochrome P450LI
    Sterol 14-alpha demethylase
    Gene namesi
    Name:CYP51A1
    Synonyms:CYP51
    ORF Names:QtsA-11582, QtsA-20162
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Lanosterol 14-alpha demethylasePRO_0000052000Add
    BLAST

    Proteomic databases

    PRIDEiQ4R8S6.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK05917.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00465. EP450IV.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4R8S6-1 [UniParc]FASTAAdd to Basket

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    MMLLGLLQAG GSVLGQAMEK VTGGNLLSML LIACAFTLSL VYLFRLAAGH    50
    LVQLPAGAKS PPYIFSPIPF LGHAIAFGKS PVEFLENAYE KYGPVFSFTM 100
    VGKTFTYLLG SDAAALLFNS KNEDLNAEDV YSRLTTPVFG KGVAYDVPNP 150
    VFLEQKKMLK SGLNIAHFKQ HVSIIEKETK EYFQSWGESG EKNVFEALSE 200
    LIILTASHCL HGKEIRSQLN EKVAQLYADL DGGFSHAAWL LPGWLPLPSF 250
    RRRDRAHREI KNIFYKAIQK RRQSQEKIDD ILQTLLDATY KDGRPLTDDE 300
    VAGMLIGLLL AGQHTSSTTS AWMGFFLARD KTLQEKCYLE QKTVCGENLP 350
    PLTYDQLKDL NLLDRCIKET LRLRPPIMIM MRMARTPQTV AGYTIPPGHQ 400
    VCVSPTVNQR LKDSWVERLD FNPDRYLQDN PASGEKFAYV PFGAGRHRCI 450
    GENFAYVQIK TIWSTMLRLY EFDLIDGYFP TVNYTTMIHT PENPVIRYKR 500
    RSK 503
    Length:503
    Mass (Da):56,815
    Last modified:May 26, 2009 - v2
    Checksum:iDEC563E20B0666DB
    GO

    Sequence cautioni

    The sequence AAZ29450.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAE00495.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAE01508.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ074804 mRNA. Translation: AAZ29450.1. Different initiation.
    AB168372 mRNA. Translation: BAE00495.1. Different initiation.
    AB169425 mRNA. Translation: BAE01508.1. Different initiation.
    RefSeqiNP_001274625.1. NM_001287696.1.
    UniGeneiMfa.1856.

    Genome annotation databases

    GeneIDi102146764.
    KEGGimcf:102146764.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ074804 mRNA. Translation: AAZ29450.1 . Different initiation.
    AB168372 mRNA. Translation: BAE00495.1 . Different initiation.
    AB169425 mRNA. Translation: BAE01508.1 . Different initiation.
    RefSeqi NP_001274625.1. NM_001287696.1.
    UniGenei Mfa.1856.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q4R8S6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 102146764.
    KEGGi mcf:102146764.

    Phylogenomic databases

    KOi K05917.

    Enzyme and pathway databases

    UniPathwayi UPA00770 ; UER00754 .

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00465. EP450IV.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of CYP cDNAs from cynomolgus monkey liver."
      Uno Y., Kito G., Kamataki T., Nagata R.
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
      International consortium for macaque cDNA sequencing and analysis
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiCP51A_MACFA
    AccessioniPrimary (citable) accession number: Q4R8S6
    Secondary accession number(s): Q4R5W7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3