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Protein

ADP/ATP translocase 4

Gene

SLC25A31

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92ADPBy similarity1
Binding sitei104ADPBy similarity1
Binding sitei247ADPBy similarity1

GO - Molecular functioni

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 4
Alternative name(s):
ADP,ATP carrier protein 4
Adenine nucleotide translocator 4
Short name:
ANT 4
Solute carrier family 25 member 31
Gene namesi
Name:SLC25A31
ORF Names:QtsA-12102
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 49Helical; Name=1By similarityAdd BLAST30
Transmembranei87 – 111Helical; Name=2By similarityAdd BLAST25
Transmembranei122 – 142Helical; Name=3By similarityAdd BLAST21
Transmembranei191 – 211Helical; Name=4By similarityAdd BLAST21
Transmembranei223 – 243Helical; Name=5By similarityAdd BLAST21
Transmembranei284 – 301Helical; Name=6By similarityAdd BLAST18

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002976251 – 315ADP/ATP translocase 4Add BLAST315

Structurei

3D structure databases

ProteinModelPortaliQ4R8M0
SMRiQ4R8M0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 110Solcar 1Add BLAST93
Repeati123 – 213Solcar 2Add BLAST91
Repeati220 – 307Solcar 3Add BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni247 – 252Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi247 – 252Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000011543
HOVERGENiHBG108348
KOiK05863

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q4R8M0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHREPPKKKA EKRLFDASSF GKDLLAGGVA AAVSKTAVAP IERVKLLLQV
60 70 80 90 100
QASSKQISPE ARYKGMVDCL VRIPREQGFF SFWRGNLANV IRYFPTQALN
110 120 130 140 150
FAFKDKYKQL FMSGVNKEKQ FWRWFLANLA SGGAAGATSL CVVYPLDFAR
160 170 180 190 200
TRLGVDIGKG PEERQFKGLG DCIMKIAKSD GIAGLYQGFG VSVQGIIVYR
210 220 230 240 250
ASYFGAYDTV KGLLPKPKKT PFLVSFFIAQ VVTTCSGILS YPFDTVRRRM
260 270 280 290 300
MMQSGEAKRQ YKGTLDCFVK IYQHEGINSF FRGAFSNVLR GTGGALVLVL
310
YDKIKEFFHI DIGGR
Length:315
Mass (Da):35,075
Last modified:July 19, 2005 - v1
Checksum:iF7D488B62760C9A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB168432 mRNA Translation: BAE00552.1
RefSeqiNP_001274602.1, NM_001287673.1
UniGeneiMfa.8989

Genome annotation databases

EnsembliENSMFAT00000011776; ENSMFAP00000037526; ENSMFAG00000038000
GeneIDi102143674
KEGGimcf:102143674

Similar proteinsi

Entry informationi

Entry nameiADT4_MACFA
AccessioniPrimary (citable) accession number: Q4R8M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health