Reviewed, UniProtKB/Swiss-Prot Q4R816 (LDH6B_MACFA)

Names and origin

Protein names

Recommended name:
    L-lactate dehydrogenase A-like 6B
    EC=1.1.1.27

Gene names

Name:	LDHAL6B
ORF Names:	QtsA-13749

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	(S)-lactate + NAD+ = pyruvate + NADH.
Pathway	Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
Sequence similarities	Belongs to the LDH/MDH superfamily. LDH family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	anaerobic glycolysis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-lactate dehydrogenase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	L-lactate dehydrogenase A-like 6B		PRO_0000261002
Regions
	Nucleotide binding	101 – 106	6	NAD By similarity
Sites
	Active site	242	1	Proton acceptor By similarity
	Binding site	148	1	NAD By similarity
	Binding site	155	1	Substrate By similarity
	Binding site	187	1	NAD or substrate By similarity
	Binding site	218	1	Substrate By similarity
	Binding site	297	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4R816-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 9D394077C58B634F	FASTA	381	42,049
	10 20 30 40 50 60 MSWTVPLVRA SQRVSSVGAN FLCLKMALCP RQAARIPLKG AWRFTSVSKM ATVKSELIER 70 80 90 100 110 120 FTSEEPVHHS KVSIIGTGSV GMACAISILL KGLIDELALV DLDEGKLKGE TMDLQHGSSF 130 140 150 160 170 180 TKMPNIVCSK DYFVTANSNL VIITAGARQE KGETRLNLVQ RNVALFKLMI SNIVQHSPHC 190 200 210 220 230 240 KLIIVSNPVD ILSYVAWKLS AFPKNRVIGS GCNLDTARFR FLIGQKLGIH SESCHGWILG 250 260 270 280 290 300 EHGDSSVPVW SGVNIAGVPL KDLNSDIGTD KDPEQWKNVH EEVIATAYEI IKMKGYTSWA 310 320 330 340 350 360 IGLSVADLTE SILKNLRRTH PVSTIIKGLY GIDEEVFLSI PCILGENGIT HLIKIKLTPE 370 380 EEDRLKKSAK TLWEIQKELK I

References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB168645 mRNA. Translation: BAE00756.1.
3D structure databases
SMR	Q4R816. Positions 51-380.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q4R816.
Enzyme and pathway databases
BRENDA	1.1.1.27. 3438.
Family and domain databases
InterPro	IPR001557. L-lactate/malate_DH. IPR011304. L-lactate_DH. IPR018177. L-lactate_DH_AS. IPR001236. Lactate/malate_DH. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
PRINTS	PR00086. LLDHDRGNASE.
TIGRFAMs	TIGR01771. L-LDH-NAD. 1 hit.
PROSITE	PS00064. L_LDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LDH6B_MACFA

Accession

Primary (citable) accession number: Q4R816

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	July 19, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)