1,5-anhydro-D-fructose reductase - Macaca fascicularis (Crab-eating macaque)

Preferred order of sections

Names and origin

Protein names

Recommended name:
1,5-anhydro-D-fructose reductase
Short name=AF reductase
EC=1.1.1.263

Alternative name(s):
Aldo-keto reductase family 1 member C-like protein 2
Aldo-keto reductase family 1 member E2

Gene names

Name:	AKR1E2
Synonyms:	AKR1CL2
ORF Names:	QtsA-13895

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones By similarity.
Catalytic activity	1,5-anhydro-D-glucitol + NADP⁺ = 1,5-anhydro-D-fructose + NADPH.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the aldo/keto reductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1,5-anhydro-D-fructose reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 320

320

1,5-anhydro-D-fructose reductase

PRO_0000287881

Regions

Nucleotide binding

269 – 277

9

NADP By similarity

Sites

Active site

40

1

Proton donor By similarity

Binding site

102

1

Substrate By similarity

Binding site

193

1

NADP By similarity

Site

69

1

Lowers pKa of active site Tyr By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q4R802 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 5D7D2F96E3FBD662
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FASTA

320

36,418

        10         20         30         40         50         60 
MGDIPAVGLS CWKASPGKVT EAVKVAIDAG YRHFNCAYFY HNEKEVGAGI RYKIKEGAVR 

        70         80         90        100        110        120 
REDLFIASKL WCTCHKKSLV KTACRRSLKA LKLNYLDLYL IHWPMGFKPP HPEWIMSCSE 

       130        140        150        160        170        180 
LSFCLSHPGV HDLPLDESDM VIPGDTDFLD TWEAMEDLVI TGLVKNIGVS NFNHEQLERL 

       190        200        210        220        230        240 
LNKPGLRFKP VTNQIECHPY LTQKNLISFC QSRGVSVTAY RPLGGSCEGV DLIDDPVIQR 

       250        260        270        280        290        300 
IAKEHSKSPA QILIRFQTQR NVIVIPGSIT PSHIKENIQV FDFELTQHDM DNILSLDRNL 

       310        320 
RLATFPITKN HKDYPFHIEY

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References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB168659 mRNA. Translation: BAE00770.1.
3D structure databases
HSSP	HSSP built from PDB template 1PWM based on UniProtKB P15121.
ProteinModelPortal	Q4R802.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000020.
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_subgr. IPR023210. NADP_OxRdtase_dom. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PIRSF	PIRSF000097. AKR. 1 hit.
PRINTS	PR00069. ALDKETRDTASE.
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
PROSITE	PS00798. ALDOKETO_REDUCTASE_1. False negative. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AKCL2_MACFA

Accession

Primary (citable) accession number: Q4R802

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	July 19, 2005
Last modified:	September 21, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families