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Protein

DnaJ homolog subfamily B member 6

Gene

DNAJB6

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity).By similarity

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 6
Gene namesi
Name:DNAJB6By similarity
ORF Names:QtsA-14076
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002923391 – 241DnaJ homolog subfamily B member 6Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiQ4R7Y5.

Interactioni

Subunit structurei

Homooligomer. Interacts with BAG3, HSPB8 and STUB1. Interacts with HSP70, KRT18 and PTTG. Interacts with ALKBH1. Interacts with histone deacetylases HDAC4, HDAC6, and SIRT2, HDAC activity is required for antiaggregation.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ4R7Y5.
SMRiQ4R7Y5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 69JPROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 146Interaction with HSP70By similarityAdd BLAST146
Regioni119 – 241Interaction with KRT18By similarityAdd BLAST123

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi69 – 186Gly-richSequence analysisAdd BLAST118
Compositional biasi155 – 194Ser-richAdd BLAST40

Domaini

The antiaggregation activity of resides in the serine-rich region and the C-terminus.By similarity

Phylogenomic databases

HOVERGENiHBG066998.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiView protein in InterPro
IPR036869. DnaJ_dom_sf.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
PfamiView protein in Pfam
PF00226. DnaJ. 1 hit.
PRINTSiPR00625. JDOMAIN.
SMARTiView protein in SMART
SM00271. DnaJ. 1 hit.
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiView protein in PROSITE
PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4R7Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDYYEVLGV QRHASPEDIK KAYRKLALKW HPDKNPENKE EAERKFKQVA
60 70 80 90 100
EAYEVLSDAK KRDIYDKYGK EGLNGGGGGG SHFDSPFEFG FTFRNPDDVF
110 120 130 140 150
REFFGGRDPF SFEFFEDPFE DFFGNRRGPR GSRSRGTGSF FSAFSGFPSF
160 170 180 190 200
GSGFSSFDTG FTSFGSLGHG GLTSFSSTSF GGGGMGNFKS ISTSTKMVNG
210 220 230 240
RKITTKRIVE NGQERVEVEE DGQLKSLTIN GKEQLLRLDN K
Length:241
Mass (Da):26,884
Last modified:July 19, 2005 - v1
Checksum:iCDAF5C6EB6783BA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB168676 mRNA. Translation: BAE00787.1.
UniGeneiMfa.8888.

Similar proteinsi

Entry informationi

Entry nameiDNJB6_MACFA
AccessioniPrimary (citable) accession number: Q4R7Y5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 19, 2005
Last modified: October 25, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program