Reviewed, UniProtKB/Swiss-Prot Q4R7U8 (ASGL1_MACFA)

Names and origin

Protein names

Recommended name:
    L-asparaginase
    EC=3.5.1.1
Alternative name(s):
    L-asparagine amidohydrolase
    Asparaginase-like protein 1

Gene names

Name:	ASRGL1
ORF Names:	QtsA-14329

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Acts in asparagine catabolism. May be involved in astroglial production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions By similarity.
Catalytic activity	L-asparagine + H2O = L-aspartate + NH3.
Subcellular location	Cytoplasm By similarity. Note: Midpiece of sperm tail By similarity.
Sequence similarities	Belongs to the Ntn-hydrolase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	asparagine catabolic process via L-aspartate Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	L-asparaginase		PRO_0000305205
Sites
	Active site	168	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4R7U8-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 2071C67D472EAE89	FASTA	308	32,127
	10 20 30 40 50 60 MNPIVVVHGG GAGPISKDRK ERMHQGIVRA ATVGYGILRE GGSAVDAVEG AVVALEDDPE 70 80 90 100 110 120 FNAGCGSVLN TDGEVEMDAS IMDGKDLSVG AVSAVRCIAN PIKLARLVME KTPHCFLTDQ 130 140 150 160 170 180 GAAQFAAAMG VPEIPGEKLV TEKNKKRLEK EKHEKGAQKT DCEKNLGTVG AVALDFKGNV 190 200 210 220 230 240 AYATSTGGIV NKMVGRVGDT PCVGAGGYAD NDIGAISTTG HGESILKVNL ARLTLFHIEQ 250 260 270 280 290 300 GKTVEEAADL SLGYMKSRVK GLGGLIVVSK TGDWVAKWTS TSMPWAAAKD GKLHFGIDPD DTAITDLP

References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB168713 mRNA. Translation: BAE00824.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	T02.002.
Phylogenomic databases
HOVERGEN	Q4R7U8.
Enzyme and pathway databases
BRENDA	3.5.1.1. 3438.
Family and domain databases
InterPro	IPR000246. Peptidase_T2. [Graphical view]
PANTHER	PTHR10188. Peptidase_T2. 1 hit.
Pfam	PF01112. Asparaginase_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASGL1_MACFA

Accession

Primary (citable) accession number: Q4R7U8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	July 19, 2005
Last modified:	May 26, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)