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Reviewed, UniProtKB/Swiss-Prot Q4R7U8 (ASGL1_MACFA)

Last modified May 26, 2009. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    L-asparaginase
    EC=3.5.1.1
Alternative name(s):
    L-asparagine amidohydrolase
    Asparaginase-like protein 1
Gene names
Name: ASRGL1
ORF Names: QtsA-14329
OrganismMacaca fascicularis (Crab eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Acts in asparagine catabolism. May be involved in astroglial production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions By similarity.

Catalytic activity

L-asparagine + H2O = L-aspartate + NH3.

Subcellular location

Cytoplasm By similarity. Note: Midpiece of sperm tail By similarity.

Sequence similarities

Belongs to the Ntn-hydrolase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological processasparagine catabolic process via L-aspartate

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular functionN4-(beta-N-acetylglucosaminyl)-L-asparaginase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308L-asparaginase
PRO_0000305205

Sites

Active site1681Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4R7U8-1 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 2071C67D472EAE89

FASTA30832,127
        10         20         30         40         50         60 
MNPIVVVHGG GAGPISKDRK ERMHQGIVRA ATVGYGILRE GGSAVDAVEG AVVALEDDPE 

        70         80         90        100        110        120 
FNAGCGSVLN TDGEVEMDAS IMDGKDLSVG AVSAVRCIAN PIKLARLVME KTPHCFLTDQ 

       130        140        150        160        170        180 
GAAQFAAAMG VPEIPGEKLV TEKNKKRLEK EKHEKGAQKT DCEKNLGTVG AVALDFKGNV 

       190        200        210        220        230        240 
AYATSTGGIV NKMVGRVGDT PCVGAGGYAD NDIGAISTTG HGESILKVNL ARLTLFHIEQ 

       250        260        270        280        290        300 
GKTVEEAADL SLGYMKSRVK GLGGLIVVSK TGDWVAKWTS TSMPWAAAKD GKLHFGIDPD 


DTAITDLP 

« Hide

References

[1]"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
International consortium for macaque cDNA sequencing and analysis
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

AB168713 mRNA. Translation: BAE00824.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

MEROPST02.002.

Phylogenomic databases

HOVERGENQ4R7U8.

Enzyme and pathway databases

BRENDA3.5.1.1. 3438.

Family and domain databases

InterProIPR000246. Peptidase_T2.
[Graphical view]
PANTHERPTHR10188. Peptidase_T2. 1 hit.
PfamPF01112. Asparaginase_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASGL1_MACFA
AccessionPrimary (citable) accession number: Q4R7U8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 19, 2005
Last modified: May 26, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents