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Q4R7T5 (CDKL2_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase-like 2

EC=2.7.11.22
Gene names
Name:CDKL2
ORF Names:QtsA-14426
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Domain

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

cyclin-dependent protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Cyclin-dependent kinase-like 2
PRO_0000085815

Regions

Domain4 – 287284Protein kinase
Nucleotide binding10 – 189ATP By similarity
Motif45 – 517[NKR]KIAxRE

Sites

Active site1261Proton acceptor By similarity
Binding site331ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4R7T5 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 4F88F8C3F820806B

FASTA57064,710
        10         20         30         40         50         60 
MEKYENLGLV GEGSYGMVVK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 

        70         80         90        100        110        120 
ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY QVVQKYLFQI INGIGFCHSH 

       130        140        150        160        170        180 
NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 

       190        200        210        220        230        240 
KAVDVWAIGC LVTEMFMGEP LFPGDSDIDQ LYHIMMCLGN LIPRHQELFY KNPVFAGVRL 

       250        260        270        280        290        300 
PEIKEREPLE RRYPKLSEVV IDLAKKCLHI DPDKRPFCSE LLHHDFFQMD GFAERFSQEL 

       310        320        330        340        350        360 
QLKVQKDARN ISLSKKSQNR KKEKEKDDSL GEERKTLVVQ DTNADPKIKD CKLFKIKGSK 

       370        380        390        400        410        420 
IDGEKAEKGN RASNASCLHD SRTSHIKIVP STSLKDCSNV SVDHTRNPGV AIPPLMHNLS 

       430        440        450        460        470        480 
AVAPGINSGM GTATLPIQSY RVDEKTKKCS IPFVKPNRHS PSGIYNINVT TLVSSEKSLF 

       490        500        510        520        530        540 
RASKKRREYS RTDVHLPELN YNHLPELRAL EGTARNSRLT KKESKILSES RIPSLAAIDL 

       550        560        570 
HTPSITLHQV SGPPLSDDSG ADLPQMEHQH 

« Hide

References

[1]"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
International consortium for macaque cDNA sequencing and analysis
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB168727 mRNA. Translation: BAE00837.1.
RefSeqNP_001270008.1. NM_001283079.1.
UniGeneMfa.904.

3D structure databases

ProteinModelPortalQ4R7T5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101926402.
KEGGmcf:101926402.

Organism-specific databases

CTD8999.

Phylogenomic databases

HOVERGENHBG080204.
KOK08824.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDKL2_MACFA
AccessionPrimary (citable) accession number: Q4R7T5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families