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Protein

Cyclin-dependent kinase-like 2

Gene

CDKL2

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 2 (EC:2.7.11.22)
Gene namesi
Name:CDKL2
ORF Names:QtsA-14426
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858151 – 570Cyclin-dependent kinase-like 2Add BLAST570

Structurei

3D structure databases

ProteinModelPortaliQ4R7T5
SMRiQ4R7T5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 287Protein kinasePROSITE-ProRule annotationAdd BLAST284

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 51[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00830000128262
HOVERGENiHBG080204
KOiK08824

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q4R7T5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYENLGLV GEGSYGMVVK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR
60 70 80 90 100
EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY
110 120 130 140 150
QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART
160 170 180 190 200
LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDVWAIGC LVTEMFMGEP
210 220 230 240 250
LFPGDSDIDQ LYHIMMCLGN LIPRHQELFY KNPVFAGVRL PEIKEREPLE
260 270 280 290 300
RRYPKLSEVV IDLAKKCLHI DPDKRPFCSE LLHHDFFQMD GFAERFSQEL
310 320 330 340 350
QLKVQKDARN ISLSKKSQNR KKEKEKDDSL GEERKTLVVQ DTNADPKIKD
360 370 380 390 400
CKLFKIKGSK IDGEKAEKGN RASNASCLHD SRTSHIKIVP STSLKDCSNV
410 420 430 440 450
SVDHTRNPGV AIPPLMHNLS AVAPGINSGM GTATLPIQSY RVDEKTKKCS
460 470 480 490 500
IPFVKPNRHS PSGIYNINVT TLVSSEKSLF RASKKRREYS RTDVHLPELN
510 520 530 540 550
YNHLPELRAL EGTARNSRLT KKESKILSES RIPSLAAIDL HTPSITLHQV
560 570
SGPPLSDDSG ADLPQMEHQH
Length:570
Mass (Da):64,710
Last modified:July 19, 2005 - v1
Checksum:i4F88F8C3F820806B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB168727 mRNA Translation: BAE00837.1
RefSeqiNP_001270008.1, NM_001283079.1
UniGeneiMfa.904

Genome annotation databases

EnsembliENSMFAT00000032645; ENSMFAP00000024505; ENSMFAG00000043830
GeneIDi101926402
KEGGimcf:101926402

Similar proteinsi

Entry informationi

Entry nameiCDKL2_MACFA
AccessioniPrimary (citable) accession number: Q4R7T5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health