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Q4R7M2

- DPEP3_MACFA

UniProt

Q4R7M2 - DPEP3_MACFA

Protein

Dipeptidase 3

Gene

DPEP3

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 2 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis By similarity.By similarity

    Catalytic activityi

    Hydrolysis of dipeptides.PROSITE-ProRule annotation

    Cofactori

    Zinc.PROSITE-ProRule annotation

    Enzyme regulationi

    Inhibited by L-penicillamine.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi97 – 971Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi99 – 991Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi196 – 1961Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi196 – 1961Zinc 2; catalyticPROSITE-ProRule annotation
    Metal bindingi269 – 2691Zinc 2; catalyticPROSITE-ProRule annotation
    Metal bindingi290 – 2901Zinc 2; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. dipeptidase activity Source: UniProtKB-KW
    2. dipeptidyl-peptidase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. metalloexopeptidase activity Source: InterPro

    GO - Biological processi

    1. male meiosis Source: UniProtKB

    Keywords - Molecular functioni

    Dipeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Biological processi

    Meiosis

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM19.004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptidase 3 (EC:3.4.13.19)
    Gene namesi
    Name:DPEP3
    ORF Names:QtsA-14814
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Membrane By similarity; Lipid-anchorGPI-anchor By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 463428Dipeptidase 3PRO_0000231611Add
    BLAST
    Propeptidei464 – 48825Removed in mature formSequence AnalysisPRO_0000231612Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi146 ↔ 225PROSITE-ProRule annotation
    Disulfide bondi297 ↔ 329PROSITE-ProRule annotation
    Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi434 – 434InterchainPROSITE-ProRule annotation
    Lipidationi463 – 4631GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.PROSITE-ProRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ4R7M2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M19 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG002339.

    Family and domain databases

    InterProiIPR000180. Dipep_AS.
    IPR028533. Dpep3.
    IPR008257. Renal_dipep_fam.
    [Graphical view]
    PANTHERiPTHR10443. PTHR10443. 1 hit.
    PTHR10443:SF14. PTHR10443:SF14. 1 hit.
    PfamiPF01244. Peptidase_M19. 1 hit.
    [Graphical view]
    PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
    PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4R7M2-1 [UniParc]FASTAAdd to Basket

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    MQPTGHEGSR ALSRRHLRRL LLLLLLLLLR QPVTRGETTT GAPRALSTLG    50
    FPSPFTTPGV PSTLTTPGLT TPGTTKTLDL RSRAQALMRD FPLVDGHNDL 100
    PQVLRQRYKN VLQDVNLRNF SHSQTSLDRL RDGLVGAQFW SASVSCQTQD 150
    QTAVRLALEQ IDLIRRMCAS YSELELVTSA EGLNSSQKLA CLIGVEGGHS 200
    LDSSLSVLRS FYVLGVRYLT LTFTCNTPWA ESSTKFTHHM YTNVSGLTSF 250
    GEKVVEELNR LGMMIDLSYA SDTLMRRVLE VSRAPVIFSH SAARAVCDNS 300
    LNVPDDILQL LKKNGGIVMV TLSMGVLQCN LLANVSTVAD HFDHIRAVIG 350
    SEFIGIGGNY DGAGRFPQGL EDVSTYPVLI EELLSRSWSE KELQGVLRGN 400
    LLRVFRQAEK VREESRAQSP MEAEFPYGQL STSCHSHLVP QNGHQATHLE 450
    VTKWPTNRVP WRSSDASPYL LPGLVAAATF PTVIQWLC 488
    Length:488
    Mass (Da):53,868
    Last modified:April 4, 2006 - v2
    Checksum:i04E628F0DB30BE6C
    GO

    Sequence cautioni

    The sequence BAE00900.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB168793 mRNA. Translation: BAE00900.1. Different initiation.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB168793 mRNA. Translation: BAE00900.1 . Different initiation.

    3D structure databases

    ProteinModelPortali Q4R7M2.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M19.004.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG002339.

    Family and domain databases

    InterProi IPR000180. Dipep_AS.
    IPR028533. Dpep3.
    IPR008257. Renal_dipep_fam.
    [Graphical view ]
    PANTHERi PTHR10443. PTHR10443. 1 hit.
    PTHR10443:SF14. PTHR10443:SF14. 1 hit.
    Pfami PF01244. Peptidase_M19. 1 hit.
    [Graphical view ]
    PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
    PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
      International consortium for macaque cDNA sequencing and analysis
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiDPEP3_MACFA
    AccessioniPrimary (citable) accession number: Q4R7M2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 44 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3