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Q4R7M2

- DPEP3_MACFA

UniProt

Q4R7M2 - DPEP3_MACFA

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Protein

Dipeptidase 3

Gene

DPEP3

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by L-penicillamine.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi97 – 971Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi99 – 991Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi196 – 1961Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi196 – 1961Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi269 – 2691Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi290 – 2901Zinc 2; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-KW
  2. dipeptidyl-peptidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. metalloexopeptidase activity Source: InterPro

GO - Biological processi

  1. male meiosis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Meiosis

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM19.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 3 (EC:3.4.13.19)
Gene namesi
Name:DPEP3
ORF Names:QtsA-14814
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 463428Dipeptidase 3PRO_0000231611Add
BLAST
Propeptidei464 – 48825Removed in mature formSequence AnalysisPRO_0000231612Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi146 ↔ 225PROSITE-ProRule annotation
Disulfide bondi297 ↔ 329PROSITE-ProRule annotation
Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi434 – 434InterchainPROSITE-ProRule annotation
Lipidationi463 – 4631GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Interactioni

Subunit structurei

Homodimer; disulfide-linked.PROSITE-ProRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ4R7M2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG002339.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR028533. Dpep3.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF14. PTHR10443:SF14. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4R7M2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPTGHEGSR ALSRRHLRRL LLLLLLLLLR QPVTRGETTT GAPRALSTLG
60 70 80 90 100
FPSPFTTPGV PSTLTTPGLT TPGTTKTLDL RSRAQALMRD FPLVDGHNDL
110 120 130 140 150
PQVLRQRYKN VLQDVNLRNF SHSQTSLDRL RDGLVGAQFW SASVSCQTQD
160 170 180 190 200
QTAVRLALEQ IDLIRRMCAS YSELELVTSA EGLNSSQKLA CLIGVEGGHS
210 220 230 240 250
LDSSLSVLRS FYVLGVRYLT LTFTCNTPWA ESSTKFTHHM YTNVSGLTSF
260 270 280 290 300
GEKVVEELNR LGMMIDLSYA SDTLMRRVLE VSRAPVIFSH SAARAVCDNS
310 320 330 340 350
LNVPDDILQL LKKNGGIVMV TLSMGVLQCN LLANVSTVAD HFDHIRAVIG
360 370 380 390 400
SEFIGIGGNY DGAGRFPQGL EDVSTYPVLI EELLSRSWSE KELQGVLRGN
410 420 430 440 450
LLRVFRQAEK VREESRAQSP MEAEFPYGQL STSCHSHLVP QNGHQATHLE
460 470 480
VTKWPTNRVP WRSSDASPYL LPGLVAAATF PTVIQWLC
Length:488
Mass (Da):53,868
Last modified:April 4, 2006 - v2
Checksum:i04E628F0DB30BE6C
GO

Sequence cautioni

The sequence BAE00900.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB168793 mRNA. Translation: BAE00900.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB168793 mRNA. Translation: BAE00900.1 . Different initiation.

3D structure databases

ProteinModelPortali Q4R7M2.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M19.002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG002339.

Family and domain databases

InterProi IPR000180. Dipep_AS.
IPR028533. Dpep3.
IPR008257. Renal_dipep_fam.
[Graphical view ]
PANTHERi PTHR10443. PTHR10443. 1 hit.
PTHR10443:SF14. PTHR10443:SF14. 1 hit.
Pfami PF01244. Peptidase_M19. 1 hit.
[Graphical view ]
PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
    International consortium for macaque cDNA sequencing and analysis
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiDPEP3_MACFA
AccessioniPrimary (citable) accession number: Q4R7M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: November 26, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3