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Q4R7M2 (DPEP3_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 31, 2012. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dipeptidase 3
EC=3.4.13.19
Gene names
Name:DPEP3
ORF Names:QtsA-14814
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis By similarity.

Catalytic activity

Hydrolysis of dipeptides.

Cofactor

Zinc By similarity.

Enzyme regulation

Inhibited by L-penicillamine By similarity.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Membrane; Lipid-anchor › GPI-anchor By similarity.

Sequence similarities

Belongs to the peptidase M19 family.

Sequence caution

The sequence BAE00900.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Chain36 – 463428Dipeptidase 3
PRO_0000231611
Propeptide464 – 48825Removed in mature form Potential
PRO_0000231612

Sites

Metal binding971Zinc 1; catalytic By similarity
Metal binding991Zinc 1; catalytic By similarity
Metal binding1961Zinc 1; catalytic By similarity
Metal binding1961Zinc 2; catalytic By similarity
Metal binding2691Zinc 2; catalytic By similarity
Metal binding2901Zinc 2; catalytic By similarity

Amino acid modifications

Lipidation4631GPI-anchor amidated serine Potential
Glycosylation3341N-linked (GlcNAc...) Potential
Disulfide bond146 ↔ 225 By similarity
Disulfide bond297 ↔ 329 By similarity
Disulfide bond434Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4R7M2 [UniParc].

Last modified April 4, 2006. Version 2.
Checksum: 04E628F0DB30BE6C

FASTA48853,868
        10         20         30         40         50         60 
MQPTGHEGSR ALSRRHLRRL LLLLLLLLLR QPVTRGETTT GAPRALSTLG FPSPFTTPGV 

        70         80         90        100        110        120 
PSTLTTPGLT TPGTTKTLDL RSRAQALMRD FPLVDGHNDL PQVLRQRYKN VLQDVNLRNF 

       130        140        150        160        170        180 
SHSQTSLDRL RDGLVGAQFW SASVSCQTQD QTAVRLALEQ IDLIRRMCAS YSELELVTSA 

       190        200        210        220        230        240 
EGLNSSQKLA CLIGVEGGHS LDSSLSVLRS FYVLGVRYLT LTFTCNTPWA ESSTKFTHHM 

       250        260        270        280        290        300 
YTNVSGLTSF GEKVVEELNR LGMMIDLSYA SDTLMRRVLE VSRAPVIFSH SAARAVCDNS 

       310        320        330        340        350        360 
LNVPDDILQL LKKNGGIVMV TLSMGVLQCN LLANVSTVAD HFDHIRAVIG SEFIGIGGNY 

       370        380        390        400        410        420 
DGAGRFPQGL EDVSTYPVLI EELLSRSWSE KELQGVLRGN LLRVFRQAEK VREESRAQSP 

       430        440        450        460        470        480 
MEAEFPYGQL STSCHSHLVP QNGHQATHLE VTKWPTNRVP WRSSDASPYL LPGLVAAATF 


PTVIQWLC

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References

[1]"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
International consortium for macaque cDNA sequencing and analysis
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB168793 mRNA. Translation: BAE00900.1. Different initiation.

3D structure databases

ProteinModelPortalQ4R7M2.
ModBaseSearch...

Protein family/group databases

MEROPSM19.004.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG002339.

Family and domain databases

InterProIPR000180. Pept_M19_AS.
IPR008257. Peptidase_M19.
[Graphical view]
PANTHERPTHR10443. PTHR10443. 1 hit.
PfamPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDPEP3_MACFA
AccessionPrimary (citable) accession number: Q4R7M2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: October 31, 2012
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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