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Q4R7M2

- DPEP3_MACFA

UniProt

Q4R7M2 - DPEP3_MACFA

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Protein
Dipeptidase 3
Gene
DPEP3, QtsA-14814
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis By similarity.

Catalytic activityi

Hydrolysis of dipeptides.

Cofactori

Zinc By similarity.

Enzyme regulationi

Inhibited by L-penicillamine By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi97 – 971Zinc 1; catalytic By similarity
Metal bindingi99 – 991Zinc 1; catalytic By similarity
Metal bindingi196 – 1961Zinc 1; catalytic By similarity
Metal bindingi196 – 1961Zinc 2; catalytic By similarity
Metal bindingi269 – 2691Zinc 2; catalytic By similarity
Metal bindingi290 – 2901Zinc 2; catalytic By similarity

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-KW
  2. dipeptidyl-peptidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. metalloexopeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. male meiosis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Meiosis

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM19.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 3 (EC:3.4.13.19)
Gene namesi
Name:DPEP3
ORF Names:QtsA-14814
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Membrane; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed prediction
Add
BLAST
Chaini36 – 463428Dipeptidase 3
PRO_0000231611Add
BLAST
Propeptidei464 – 48825Removed in mature form Reviewed prediction
PRO_0000231612Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi146 ↔ 225 By similarity
Disulfide bondi297 ↔ 329 By similarity
Glycosylationi334 – 3341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi434 – 434Interchain By similarity
Lipidationi463 – 4631GPI-anchor amidated serine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ4R7M2.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG002339.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR028533. Dpep3.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF14. PTHR10443:SF14. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4R7M2-1 [UniParc]FASTAAdd to Basket

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MQPTGHEGSR ALSRRHLRRL LLLLLLLLLR QPVTRGETTT GAPRALSTLG    50
FPSPFTTPGV PSTLTTPGLT TPGTTKTLDL RSRAQALMRD FPLVDGHNDL 100
PQVLRQRYKN VLQDVNLRNF SHSQTSLDRL RDGLVGAQFW SASVSCQTQD 150
QTAVRLALEQ IDLIRRMCAS YSELELVTSA EGLNSSQKLA CLIGVEGGHS 200
LDSSLSVLRS FYVLGVRYLT LTFTCNTPWA ESSTKFTHHM YTNVSGLTSF 250
GEKVVEELNR LGMMIDLSYA SDTLMRRVLE VSRAPVIFSH SAARAVCDNS 300
LNVPDDILQL LKKNGGIVMV TLSMGVLQCN LLANVSTVAD HFDHIRAVIG 350
SEFIGIGGNY DGAGRFPQGL EDVSTYPVLI EELLSRSWSE KELQGVLRGN 400
LLRVFRQAEK VREESRAQSP MEAEFPYGQL STSCHSHLVP QNGHQATHLE 450
VTKWPTNRVP WRSSDASPYL LPGLVAAATF PTVIQWLC 488
Length:488
Mass (Da):53,868
Last modified:April 4, 2006 - v2
Checksum:i04E628F0DB30BE6C
GO

Sequence cautioni

The sequence BAE00900.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB168793 mRNA. Translation: BAE00900.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB168793 mRNA. Translation: BAE00900.1 . Different initiation.

3D structure databases

ProteinModelPortali Q4R7M2.
ModBasei Search...

Protein family/group databases

MEROPSi M19.004.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG002339.

Family and domain databases

InterProi IPR000180. Dipep_AS.
IPR028533. Dpep3.
IPR008257. Renal_dipep_fam.
[Graphical view ]
PANTHERi PTHR10443. PTHR10443. 1 hit.
PTHR10443:SF14. PTHR10443:SF14. 1 hit.
Pfami PF01244. Peptidase_M19. 1 hit.
[Graphical view ]
PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
    International consortium for macaque cDNA sequencing and analysis
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiDPEP3_MACFA
AccessioniPrimary (citable) accession number: Q4R7M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: September 3, 2014
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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