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Protein

Dipeptidase 3

Gene

DPEP3

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by L-penicillamine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi97Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi99Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi196Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi196Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi269Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi290Zinc 2; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDipeptidase, Hydrolase, Metalloprotease, Protease
Biological processMeiosis
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM19.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 3 (EC:3.4.13.19)
Gene namesi
Name:DPEP3
ORF Names:QtsA-14814
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000023161136 – 463Dipeptidase 3Add BLAST428
PropeptideiPRO_0000231612464 – 488Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi146 ↔ 225PROSITE-ProRule annotation
Disulfide bondi297 ↔ 329PROSITE-ProRule annotation
Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi434InterchainPROSITE-ProRule annotation
Lipidationi463GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Interacts with TEX101; co-localized on the cell surface of spermatocytes, spermatids, and testicular spermatozoa, co-localized only in cytoplasmic droplets of caput and corpus epididymal sperm (By similarity).PROSITE-ProRule annotationBy similarity

Structurei

3D structure databases

ProteinModelPortaliQ4R7M2.
SMRiQ4R7M2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG002339.
KOiK01273.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiView protein in InterPro
IPR000180. Dipep_AS.
IPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiView protein in Pfam
PF01244. Peptidase_M19. 1 hit.
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiView protein in PROSITE
PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4R7M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPTGHEGSR ALSRRHLRRL LLLLLLLLLR QPVTRGETTT GAPRALSTLG
60 70 80 90 100
FPSPFTTPGV PSTLTTPGLT TPGTTKTLDL RSRAQALMRD FPLVDGHNDL
110 120 130 140 150
PQVLRQRYKN VLQDVNLRNF SHSQTSLDRL RDGLVGAQFW SASVSCQTQD
160 170 180 190 200
QTAVRLALEQ IDLIRRMCAS YSELELVTSA EGLNSSQKLA CLIGVEGGHS
210 220 230 240 250
LDSSLSVLRS FYVLGVRYLT LTFTCNTPWA ESSTKFTHHM YTNVSGLTSF
260 270 280 290 300
GEKVVEELNR LGMMIDLSYA SDTLMRRVLE VSRAPVIFSH SAARAVCDNS
310 320 330 340 350
LNVPDDILQL LKKNGGIVMV TLSMGVLQCN LLANVSTVAD HFDHIRAVIG
360 370 380 390 400
SEFIGIGGNY DGAGRFPQGL EDVSTYPVLI EELLSRSWSE KELQGVLRGN
410 420 430 440 450
LLRVFRQAEK VREESRAQSP MEAEFPYGQL STSCHSHLVP QNGHQATHLE
460 470 480
VTKWPTNRVP WRSSDASPYL LPGLVAAATF PTVIQWLC
Length:488
Mass (Da):53,868
Last modified:April 4, 2006 - v2
Checksum:i04E628F0DB30BE6C
GO

Sequence cautioni

The sequence BAE00900 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB168793 mRNA. Translation: BAE00900.1. Different initiation.
RefSeqiNP_001306334.1. NM_001319405.1.
UniGeneiMfa.6954.

Genome annotation databases

GeneIDi102124306.
KEGGimcf:102124306.

Similar proteinsi

Entry informationi

Entry nameiDPEP3_MACFA
AccessioniPrimary (citable) accession number: Q4R7M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: September 27, 2017
This is version 57 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families