ID   NUD12_MACFA             Reviewed;         462 AA.
AC   Q4R7L8;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Peroxisomal NADH pyrophosphatase NUDT12;
DE            EC=3.6.1.22;
DE   AltName: Full=Nucleoside diphosphate-linked moiety X motif 12;
DE            Short=Nudix motif 12;
GN   Name=NUDT12; ORFNames=QtsA-14876;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and
CC       diadenosine diphosphate to AMP. Has also activity towards
CC       NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to
CC       regulate the concentration of peroxisomal nicotinamide nucleotide
CC       cofactors required for oxidative metabolism in this organelle (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: NAD(+) + H(2)O = AMP + NMN.
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SUBCELLULAR LOCATION: Peroxisome (By similarity).
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. NudC subfamily.
CC   -!- SIMILARITY: Contains 3 ANK repeats.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AB168797; BAE00904.1; -; mRNA.
DR   HOVERGEN; Q4R7L8; -.
DR   BRENDA; 3.6.1.22; 3438.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000210; F:NAD+ diphosphatase activity; IEA:EC.
DR   InterPro; IPR002110; ANK.
DR   InterPro; IPR015375; NADH_PPase-like_N.
DR   InterPro; IPR000086; NUDIX_hydrolase_core.
DR   InterPro; IPR015376; Znr_NADH_PPase.
DR   Gene3D; G3DSA:1.25.40.20; ANK; 1.
DR   Gene3D; G3DSA:3.90.79.10; NUDIX_hydrolase; 1.
DR   Pfam; PF00023; Ank; 2.
DR   Pfam; PF00293; NUDIX; 1.
DR   Pfam; PF09296; NUDIX-like; 1.
DR   Pfam; PF09297; zf-NADH-PPase; 1.
DR   SMART; SM00248; ANK; 3.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS00893; NUDIX; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Hydrolase; Magnesium; Manganese; Metal-binding; NAD; NADP;
KW   Peroxisome; Repeat.
FT   CHAIN         1    462       Peroxisomal NADH pyrophosphatase NUDT12.
FT                                /FTId=PRO_0000260766.
FT   REPEAT       11     40       ANK 1.
FT   REPEAT       45     74       ANK 2.
FT   REPEAT       78     98       ANK 3.
FT   MOTIF       355    376       Nudix box.
FT   MOTIF       460    462       Microbody targeting signal (By
FT                                similarity).
FT   METAL       370    370       Magnesium or manganese (By similarity).
FT   METAL       374    374       Magnesium or manganese (By similarity).
SQ   SEQUENCE   462 AA;  52092 MW;  BD4B6171E80DCB25 CRC64;
     MSSVKRSPKQ EIVTQFHCSA AEGDIAKLTG ILSHSPSLLN ETSENGWTAL MYAARNGHPE
     IVQFLLEKGC DRSIVNKSRQ TALDIAVFWG YKHIANLLAT AKGGKKPWFL TNEVEECENY
     FSKTLLDRKS EKRNNADWLL AKESHPATVF ILFSDLNPLV TLGGNKESFQ QPEVRLCQLN
     YKDIKDYLAQ PEEITLIFLG VELEMKDKLL NYAGEVPREE EDGLVAWFAL GIDPIAAEEF
     KQRHENCYFL HPPMPALLQL KEKEAGVVAQ ARSVLAWHSR YKFCPTCGNG TKIEEGGYKR
     VCLKEDCPSL NGVHNTSYPR VDPVVIMQVI HPDGTRCLLG RQKRFPPGMF TCLAGFIEPG
     ETIEDAVRRE VEEESGVKVG HVQYVSCQPW PMPSSLMIGC LAVAVSTEIK VDKNEIEDAR
     WFTREQVLDV LTKGKQQAFF VPPSRAIAHQ LIKHWIRINP NL
//