Q4R7L8 (NUD12_MACFA) Reviewed, UniProtKB/Swiss-Prot
Last modified
October 19, 2011.
Version 37.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Peroxisomal NADH pyrophosphatase NUDT12 EC=3.6.1.22 Alternative name(s): Nucleoside diphosphate-linked moiety X motif 12 Short name=Nudix motif 12 | ||||
| Gene names |
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| Organism | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) | ||||
| Taxonomic identifier | 9541 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Protein attributes
| Sequence length | 462 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)+, ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle By similarity. |
| Catalytic activity | NAD+ + H2O = AMP + NMN. |
| Cofactor | Magnesium or manganese By similarity. |
| Subcellular location | Peroxisome By similarity. |
| Sequence similarities | Belongs to the Nudix hydrolase family. NudC subfamily. Contains 3 ANK repeats. Contains 1 nudix hydrolase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Peroxisome |
| Domain | ANK repeat Repeat |
| Ligand | Magnesium Manganese Metal-binding NAD NADP |
| Molecular function | Hydrolase |
| Gene Ontology (GO) | |
| Cellular component | peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | NAD+ diphosphatase activity Inferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 462 | 462 | Peroxisomal NADH pyrophosphatase NUDT12 | PRO_0000260766 | |||||
Regions | |||||||||
| Repeat | 11 – 40 | 30 | ANK 1 | ||||||
| Repeat | 45 – 74 | 30 | ANK 2 | ||||||
| Repeat | 78 – 98 | 21 | ANK 3 | ||||||
| Domain | 319 – 453 | 135 | Nudix hydrolase | ||||||
| Motif | 355 – 376 | 22 | Nudix box | ||||||
| Motif | 460 – 462 | 3 | Microbody targeting signal By similarity | ||||||
Sites | |||||||||
| Metal binding | 370 | 1 | Magnesium or manganese By similarity | ||||||
| Metal binding | 374 | 1 | Magnesium or manganese By similarity | ||||||
Sequences
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References
| [1] | "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB168797 mRNA. Translation: BAE00904.1. |
3D structure databases | |
| ProteinModelPortal | Q4R7L8. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| HOVERGEN | HBG054394. |
Family and domain databases | |
| InterPro | IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR015375. NADH_PPase-like_N. IPR020084. NUDIX_hydrolase_CS. IPR000086. NUDIX_hydrolase_dom. IPR015797. NUDIX_hydrolase_dom-like. IPR015376. Znr_NADH_PPase. [Graphical view] |
| Gene3D | G3DSA:1.25.40.20. ANK. 1 hit. G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit. |
| Pfam | PF12796. Ank_2. 1 hit. PF00293. NUDIX. 1 hit. PF09296. NUDIX-like. 1 hit. PF09297. zf-NADH-PPase. 1 hit. [Graphical view] |
| SMART | SM00248. ANK. 3 hits. [Graphical view] |
| SUPFAM | SSF48403. ANK. 1 hit. SSF55811. NUDIX_hydrolase. 1 hit. |
| PROSITE | PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. PS51462. NUDIX. 1 hit. PS00893. NUDIX_BOX. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NUD12_MACFA | ||||||||
| Accession | Primary (citable) accession number: Q4R7L8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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