Q4R7D9 (PSA7L_MACFA) Reviewed, UniProtKB/Swiss-Prot
Last modified June 11, 2014. Version 49. History...
Names and origin
|Protein names||Recommended name:|
Proteasome subunit alpha type-7-like
|Organism||Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)|
|Taxonomic identifier||9541 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca|
|Sequence length||250 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Component of the spermatoproteasome, a form of the proteasome specifically found in testis that promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH By similarity.
Cleavage of peptide bonds with very broad specificity.
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.
Belongs to the peptidase T1A family.
|Gene Ontology (GO)|
|Biological_process||ubiquitin-dependent protein catabolic process|
Inferred from electronic annotation. Source: InterPro
Inferred from electronic annotation. Source: UniProtKB-SubCellnucleus
Inferred from electronic annotation. Source: UniProtKB-SubCellproteasome core complex, alpha-subunit complex
Inferred from electronic annotation. Source: InterProspermatoproteasome complex
Inferred from sequence or structural similarity. Source: UniProtKB
|Molecular_function||threonine-type endopeptidase activity|
Inferred from electronic annotation. Source: UniProtKB-KW
|Complete GO annotation...|
Sequence annotation (Features)
|||"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."|
International consortium for macaque cDNA sequencing and analysis
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
|AB168880 mRNA. Translation: BAE00983.1.|
|RefSeq||NP_001270892.1. NM_001283963.1. |
3D structure databases
|SMR||Q4R7D9. Positions 5-234. |
Protein family/group databases
Protocols and materials databases
Genome annotation databases
Family and domain databases
|Gene3D||220.127.116.11. 1 hit. |
|InterPro||IPR029055. Ntn_hydrolases_N. |
|Pfam||PF00227. Proteasome. 1 hit. |
PF10584. Proteasome_A_N. 1 hit.
|SMART||SM00948. Proteasome_A_N. 1 hit. |
|SUPFAM||SSF56235. SSF56235. 1 hit. |
|PROSITE||PS00388. PROTEASOME_ALPHA_1. 1 hit. |
PS51475. PROTEASOME_ALPHA_2. 1 hit.
|Accession||Primary (citable) accession number: Q4R7D9|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|