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Q4R755

- GPDM_MACFA

UniProt

Q4R755 - GPDM_MACFA

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Protein
Glycerol-3-phosphate dehydrogenase, mitochondrial
Gene
GPD2, QtsA-16270
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FAD By similarity.

Enzyme regulationi

Calcium-binding enhance the activity of the enzyme By similarity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 9929FAD Reviewed prediction
Add
BLAST
Calcium bindingi672 – 68312 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycerol catabolic process Source: UniProtKB-UniPathway
  2. glycerol-3-phosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Calcium, FAD, Flavoprotein, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00618; UER00674.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
Short name:
GPD-M
Short name:
GPDH-M
Alternative name(s):
mtGPD
Gene namesi
Name:GPD2
ORF Names:QtsA-16270
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  2. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242Mitochondrion By similarity
Add
BLAST
Chaini43 – 727685Glycerol-3-phosphate dehydrogenase, mitochondrial
PRO_0000270069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei601 – 6011Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ4R755.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini623 – 65836EF-hand 1
Add
BLAST
Domaini659 – 69436EF-hand 2
Add
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

HOVERGENiHBG005897.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4R755-1 [UniParc]FASTAAdd to Basket

« Hide

MAFQKAVKGT ILVGGGALAT VLGLSQFAHY RRKQMNLAYV KAADYISEPV    50
NREPPSREAQ LLTLQNTSEF DILVIGGGAT GSGCALDAVT RGLKTALVER 100
DDFSSGTSSR STKLIHGGVR YLQKAIMKLD IEQYRMVKEA LHERANLLEI 150
APHLSAPLPI VLPVYKWWQL PYYWVGIKLY DLVAGSNCLK SSYVLSKSRA 200
LEHFPMLQKD KLVGAIVYYD GQHNDARMNL AIALTAARYG AATANYMEVV 250
SLLKKTDPQT GKVRVSGARC KDVLTGQEFD VRAKCVINAT GPFTDSVRKM 300
DDKDAAAICQ PSAGVHIVMP GYYSPESMGL LDPATSDGRV IFFLPWQKMT 350
IAGTTDTPTD VTPHPIPSEE DINFILNEVR NYLSCDVEVR RGDVLAAWSG 400
IRPLVTDPKS ADTQSISRNH VVDISESGLI TIAGGKWTTY RSMAEDTINA 450
AIKTHNLKAG PSRTVGLFLQ GGKDWSPTLY IRLVQDYGLE SEVAQHLAAT 500
YGDKAFEVAK MASVTGKRWP IVGVRLVSEF PYIEAEVKYG IKEYACTAVD 550
MISRRTRLAF LNVQAAEEAL PRIVELMGRE LNWDDHKKQE QLETAKKFLY 600
YEMGYKSRSE QLTDRSEISL LPSDIDRYKK RFHKFDADKK GFITIVDVQR 650
VLESINVQMD ENTLHEILNE VDLNKNGQVE LNEFLQLMSA IQKGRVSGSR 700
LAILMKTAEE NLDRRVPIPV DRSCGGL 727
Length:727
Mass (Da):80,801
Last modified:July 19, 2005 - v1
Checksum:iCFB9E66271721B66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB168970 mRNA. Translation: BAE01068.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB168970 mRNA. Translation: BAE01068.1 .

3D structure databases

ProteinModelPortali Q4R755.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005897.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00674 .

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view ]
Pfami PF01266. DAO. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
PRINTSi PR01001. FADG3PDH.
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
    International consortium for macaque cDNA sequencing and analysis
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiGPDM_MACFA
AccessioniPrimary (citable) accession number: Q4R755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 19, 2005
Last modified: November 13, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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