ID   P5CR2_MACFA             Reviewed;         320 AA.
AC   Q4R6W7;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Pyrroline-5-carboxylate reductase 2;
DE            Short=P5C reductase 2;
DE            Short=P5CR 2;
DE            EC=1.5.1.2;
GN   Name=PYCR2; ORFNames=QtsA-16987;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SUBUNIT: Homodecamer; composed of 5 homodimers (By similarity).
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
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DR   EMBL; AB169063; BAE01157.1; -; mRNA.
DR   SMR; Q4R6W7; 1-275.
DR   HOVERGEN; Q4R6W7; -.
DR   BRENDA; 1.5.1.2; 3438.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Amino-acid biosynthesis; NADP; Oxidoreductase;
KW   Phosphoprotein; Proline biosynthesis.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    320       Pyrroline-5-carboxylate reductase 2.
FT                                /FTId=PRO_0000270818.
FT   MOD_RES       2      2       N-acetylserine (By similarity).
FT   MOD_RES     304    304       Phosphoserine (By similarity).
SQ   SEQUENCE   320 AA;  33661 MW;  0CD7B0C628866BD7 CRC64;
     MSVGIIGAGQ LAYALARGFT AAGIVSAHKI IASSPEMNLP TVSALRKMGV NLTRSNKETV
     KHSDVLFLAV KPHIIPFILD EIGADVQARH IVVSCAAGVT ISSVEKKLMA FQPAPKVIRC
     MTNTPVVVRE GATVYAMGTH ALVEDGQLLE QLMSSVGFCT EVEEDLIDAV TGLSGSGPAY
     AFMALDALAD GGVKMGLPRR LAVRLGAQAL LGAAKMLLDS EQHPCQLKDN VCSPGGATIH
     ALHFLESGGF RSLLINAVEA SCIRTRELQS MADQEKISPA ALKKTLLDRV KLESPTVSTL
     TPSSPGKLLT RSLALGGKKD
//