Reviewed, UniProtKB/Swiss-Prot Q4R6S5 (DYRK3_MACFA)

Names and origin

Protein names

Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 3
    EC=2.7.12.1

Gene names

Name:	DYRK3
ORF Names:	QtsA-17232

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	568 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling By similarity. UniProtKB O43781 UniProtKB Q922Y0
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. UniProtKB O43781 UniProtKB Q922Y0
Cofactor	Magnesium By similarity. UniProtKB O43781 UniProtKB Q922Y0
Subcellular location	Nucleus By similarity UniProtKB O43781.
Post-translational modification	Autophosphorylated on tyrosine residues By similarity. UniProtKB O43781
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	erythrocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB protein amino acid phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	ATP binding Inferred from sequence or structural similarity. Source: UniProtKB magnesium ion binding Inferred from sequence or structural similarity. Source: UniProtKB protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 568	568	Dual specificity tyrosine-phosphorylation-regulated kinase 3		PRO_0000291536
Regions
	Domain	189 – 502	314	Protein kinase
	Nucleotide binding	195 – 203	9	ATP By similarity
Sites
	Active site	315	1	Proton acceptor By similarity UniProtKB P28523
	Binding site	218	1	ATP By similarity UniProtKB Q922Y0
Amino acid modifications
	Modified residue	189	1	Phosphotyrosine By similarity UniProtKB O43781
	Modified residue	298	1	Phosphoserine By similarity
	Modified residue	349	1	Phosphotyrosine By similarity UniProtKB Q922Y0

Sequences

	Sequence		Length	Mass (Da)
	Q4R6S5-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: C7278981ABC34D7C	FASTA	568	64,088
	10 20 30 40 50 60 MKWKEKLGDG VYDTFMMIDE TKCPPCSNVL CNPSEPPPPR RLNMTTEKFI RDHTQHFLDG 70 80 90 100 110 120 GEMKVEQLFQ EFGNRKSNTV QSDGISDSEK CSPTVSQGKS SDCLNTVKSN SSSKAPKVVP 130 140 150 160 170 180 LTPEQALKQY KHHLTAYEKL EIINYPEIYF VGPNAKKRHG VIGGPNNGGY DDADGAYIHV 190 200 210 220 230 240 PRDHLAYRYE VLKIIGKGSF GQVARVYDHK LRQYVALKMV RNEKRFHRQA AEEIRILEHL 250 260 270 280 290 300 KKQDKTGSMN VIHMLESFTF RNHVCMAFEL LSIDLYELIK KNKFQGFSVQ LVRKFAQSIL 310 320 330 340 350 360 QSLDALHKNK IIHCDLKPEN ILLKHHGRSS TKVIDFGSSC FEYQKLYTYI QSRFYRAPEI 370 380 390 400 410 420 ILGSRYSTPI DIWSFGCILA ELLTGQPLFP GEDEGDQLAC MMELLGMPPP KLLEQSKRAK 430 440 450 460 470 480 YFINSKGIPR YCSVTTQADG RVVLVGGRSR RGKKRGPPGS KDWGTALKGC DDYLFIEFLK 490 500 510 520 530 540 RCLHWDPSAR LTPAQALRHP WISKSVPRPL TTIDKVSGKR IVNPASAFQG LGSKLPPVVG 550 560 IANKLKANLM SETNGSIPLC SVLPKLIS

References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB169105 mRNA. Translation: BAE01199.1.
3D structure databases
HSSP	HSSP built from PDB template 2BAJ based on UniProtKB Q16539.
SMR	Q4R6S5. Positions 111-504.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q4R6S5.
Enzyme and pathway databases
BRENDA	2.7.12.1. 3438.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DYRK3_MACFA

Accession

Primary (citable) accession number: Q4R6S5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	July 19, 2005
Last modified:	January 19, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)