ID   TPTE2_MACFA             Reviewed;         566 AA.
AC   Q4R6N0;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   05-MAY-2009, entry version 33.
DE   RecName: Full=Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2;
DE            EC=3.1.3.67;
GN   Name=TPTE2; ORFNames=QtsA-17567;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Phosphatidylinositol 3,4,5-trisphosphate +
CC       H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- SIMILARITY: Contains 1 C2 tensin-type domain.
CC   -!- SIMILARITY: Contains 1 phosphatase tensin-type domain.
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DR   EMBL; AB169152; BAE01245.1; -; mRNA.
DR   HOVERGEN; Q4R6N0; -.
DR   BRENDA; 3.1.3.67; 3438.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-...; IEA:EC.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphata...; IEA:InterPro.
DR   GO; GO:0006470; P:protein amino acid dephosphorylation; IEA:InterPro.
DR   InterPro; IPR014019; Phosphatase_tensin-typ.
DR   InterPro; IPR014020; Tensin_phosphatase_C2-dom.
DR   InterPro; IPR000340; Tyr_Pase_dual_specific.
DR   Pfam; PF00782; DSPc; 1.
DR   Pfam; PF10409; PTEN_C2; 1.
DR   PROSITE; PS51182; C2_TENSIN; 1.
DR   PROSITE; PS51181; PPASE_TENSIN; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Hydrolase; Membrane; Phosphoprotein;
KW   Transmembrane.
FT   CHAIN         1    566       Phosphatidylinositol-3,4,5-trisphosphate
FT                                3-phosphatase TPTE2.
FT                                /FTId=PRO_0000224188.
FT   TRANSMEM    135    155       Potential.
FT   TRANSMEM    173    193       Potential.
FT   TRANSMEM    208    228       Potential.
FT   TRANSMEM    234    254       Potential.
FT   DOMAIN      272    448       Phosphatase tensin-type.
FT   DOMAIN      455    566       C2 tensin-type.
FT   ACT_SITE    382    382       Phosphocysteine intermediate (By
FT                                similarity).
SQ   SEQUENCE   566 AA;  65234 MW;  ADD94DEBBA51F5AB CRC64;
     MCRVMKASFS RKVKLELCLL SDCALLSSSS APTNELSGTN LEAHINESPD PNALVGVIIE
     RSPSDSTQTN EFKGATKETL TIETPHSSEC KGAGLLSPVS KSMLERLSKF EVEDAENVAS
     YDTKIKKIVR SIVSSFAFGI FGVFLVLLDV TLLLADLIFN DSKLYIPLVY RSISLAIALF
     FLMDVLLRVF VEGRQHYFSD LLNVLDTAII VTPLLVDVVY IFFDIKFLRN IPRWIHLVRL
     LRLIILIRIF HLIHQKRELE KLMRRLVSEN KRRYTRDGFD LDLTYVTERI IAMSFPSSGR
     QSFYRNPIEE VVRFLDKKHP NHYRVYNLCS ERAYDPKYFH NRVSRIMIDD HNVPTLHEMV
     VFTKEVNEWM AQDPANIVAI HCKGGKGRTG TMICAFLIAS EIFLTAEESL YYFGERRTDK
     TNSSKFQGVE TPSQNRYVGY FAQVKHLYNW NLPPRRILFI KRFIIYSIRG VGTGGVCDLK
     VRIVMEKKVV FSSTSLGNCS ILHDIETDRV LIDVFSGPPL YDDVKVQFFS SNLPKYYDNC
     PFFFWFNTSF IQSNRHILHS FRLVFT
//