Reviewed, UniProtKB/Swiss-Prot Q4R6N0 (TPTE2_MACFA)

Names and origin

Protein names

Recommended name:
    Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2
    EC=3.1.3.67

Gene names

Name:	TPTE2
ORF Names:	QtsA-17567

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	566 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 4,5-bisphosphate + phosphate.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Contains 1 C2 tensin-type domain. Contains 1 phosphatase tensin-type domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine phosphatase activity Inferred from electronic annotation. Source: InterPro protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 566	566	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2		PRO_0000224188
Regions
	Transmembrane	135 – 155	21	Potential
	Transmembrane	173 – 193	21	Potential
	Transmembrane	208 – 228	21	Potential
	Transmembrane	234 – 254	21	Potential
	Domain	272 – 448	177	Phosphatase tensin-type
	Domain	455 – 566	112	C2 tensin-type
Sites
	Active site	382	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4R6N0-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: ADD94DEBBA51F5AB	FASTA	566	65,234
	10 20 30 40 50 60 MCRVMKASFS RKVKLELCLL SDCALLSSSS APTNELSGTN LEAHINESPD PNALVGVIIE 70 80 90 100 110 120 RSPSDSTQTN EFKGATKETL TIETPHSSEC KGAGLLSPVS KSMLERLSKF EVEDAENVAS 130 140 150 160 170 180 YDTKIKKIVR SIVSSFAFGI FGVFLVLLDV TLLLADLIFN DSKLYIPLVY RSISLAIALF 190 200 210 220 230 240 FLMDVLLRVF VEGRQHYFSD LLNVLDTAII VTPLLVDVVY IFFDIKFLRN IPRWIHLVRL 250 260 270 280 290 300 LRLIILIRIF HLIHQKRELE KLMRRLVSEN KRRYTRDGFD LDLTYVTERI IAMSFPSSGR 310 320 330 340 350 360 QSFYRNPIEE VVRFLDKKHP NHYRVYNLCS ERAYDPKYFH NRVSRIMIDD HNVPTLHEMV 370 380 390 400 410 420 VFTKEVNEWM AQDPANIVAI HCKGGKGRTG TMICAFLIAS EIFLTAEESL YYFGERRTDK 430 440 450 460 470 480 TNSSKFQGVE TPSQNRYVGY FAQVKHLYNW NLPPRRILFI KRFIIYSIRG VGTGGVCDLK 490 500 510 520 530 540 VRIVMEKKVV FSSTSLGNCS ILHDIETDRV LIDVFSGPPL YDDVKVQFFS SNLPKYYDNC 550 560 PFFFWFNTSF IQSNRHILHS FRLVFT

References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB169152 mRNA. Translation: BAE01245.1.
3D structure databases
SMR	Q4R6N0. Positions 272-559.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q4R6N0.
Enzyme and pathway databases
BRENDA	3.1.3.67. 3438.
Family and domain databases
InterPro	IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR000340. Dual-sp_phosphatase_cat-dom. IPR014019. Phosphatase_tensin-typ. IPR014020. Tensin_phosphatase_C2-dom. IPR016130. Tyr_Pase_AS. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. PF10409. PTEN_C2. 1 hit. [Graphical view]
PROSITE	PS51182. C2_TENSIN. 1 hit. PS51181. PPASE_TENSIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPTE2_MACFA

Accession

Primary (citable) accession number: Q4R6N0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	July 19, 2005
Last modified:	January 19, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)