Q4R6E3 (INO1_MACFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol-3-phosphate synthase 1
Short name=IPS 1
EC=5.5.1.4

Alternative name(s):
Myo-inositol-1-phosphate synthase
Short name=MI-1-P synthase
Short name=MIP synthase

Gene names

Name:	ISYNA1
Synonyms:	INO1
ORF Names:	QtsA-10667, QtsA-18180

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds By similarity.
Catalytic activity	D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.
Cofactor	NAD By similarity.
Pathway	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the myo-inositol-1-phosphate synthase family.

Ontologies

Keywords
Biological process	Inositol biosynthesis Phospholipid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	inositol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	inositol-3-phosphate synthase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 559	559	Inositol-3-phosphate synthase 1		PRO_0000324629
Experimental info
	Sequence conflict	428	1	L → P in BAE00364. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q4R6E3 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: D3AA731F2D48642D	FASTA	559	61,059
	10 20 30 40 50 60 MEAAAQFFVE SPDVVYGPEA IEAQYEYRTT RVSREGGVLK VHPTSTRFTF RTARQVPRLG 70 80 90 100 110 120 VMLVGWGGNN GSTLTAAVLA NRLRLSWPTR SGRKEANYYG SLTQAGTVSL GLDAEGQEVF 130 140 150 160 170 180 VPFSALLPMV APNDLVFDGW DISSLNLAEA MRRAKVLDWG LQEQLWPHME ALRPRPSVYI 190 200 210 220 230 240 PEFIAANQSA RADNLIPGSR AQQLEQIRRD IRDFRSSAGL DKIIVLWTAN TERFCEVIPG 250 260 270 280 290 300 LNDTAENLLR TIELGLEVSP STLFAVASIL EGCAFLNGSP QNTLVPGALE LAWQRRVFVG 310 320 330 340 350 360 GDDFKSGQTK VKSVLVDFLI GSGLKTMSIV SYNHLGNNDG ENLSAPLQFR SKEVSKSNVV 370 380 390 400 410 420 DDMVQSNPVL YAPGEEPDHC VVIKYVPYVG DSKRALDEYT SELMLGGTNT LVLHNTCEDS 430 440 450 460 470 480 LLAAPIMLDL ALLTELCQRV SFCTDADPEP QTFHPVLSLL SFLFKAPLVP PGSPVVNALF 490 500 510 520 530 540 RQRSCIENIL RACLGLPPQN HMLLEHKMER PGPVLKRVGP VAAACPVLNK KGPVPAATNG 550 CTGDANGHLQ VEEPQMPTT

References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB168239 mRNA. Translation: BAE00364.1. AB169241 mRNA. Translation: BAE01332.1.
3D structure databases
HSSP	HSSP built from PDB template 1P1H based on UniProtKB P11986.
ProteinModelPortal	Q4R6E3.
SMR	Q4R6E3. Positions 6-512.
ModBase	Search...
Proteomic databases
PRIDE	Q4R6E3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG061200.
Family and domain databases
InterPro	IPR002587. Myo-inos-1-P_Synthase. IPR013021. Myo-inos-1-P_Synthase_GAPDH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
PANTHER	PTHR11510. Inos-1-P_synth. 1 hit.
Pfam	PF01658. Inos-1-P_synth. 1 hit. PF07994. NAD_binding_5. 1 hit. [Graphical view]
PIRSF	PIRSF015578. Myoinos-ppht_syn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

INO1_MACFA

Accession

Primary (citable) accession number: Q4R6E3
Secondary accession number(s): Q4R957

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 19, 2005
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program