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Q4R6D3

- UBP50_MACFA

UniProt

Q4R6D3 - UBP50_MACFA

Protein

Putative ubiquitin carboxyl-terminal hydrolase 50

Gene

USP50

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    • Comment

    Functioni

    May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei53 – 531NucleophilePROSITE-ProRule annotation
    Active sitei322 – 3221Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.058.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ubiquitin carboxyl-terminal hydrolase 50 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 50
    Ubiquitin thioesterase 50
    Ubiquitin-specific-processing protease 50
    Gene namesi
    Name:USP50
    ORF Names:QtsA-18237
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373Putative ubiquitin carboxyl-terminal hydrolase 50PRO_0000249528Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ4R6D3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 364321USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    HOVERGENiHBG098592.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4R6D3-1 [UniParc]FASTAAdd to Basket

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    MTSQRSLPAD DFGIYYVLAE CTDYYDTLPV KEADGSQPCS QGVTGLRNLG    50
    NTCYMNAILQ CLCSISPLVE YFLSGKYITA LQNDCSEVAT AFAYLMTDMW 100
    LGDSDCVSPE IFRSALGNLY PAFTKKTQQD AQEFLIYVLN ELHEALKKYH 150
    YPRRRSHEKG SAQRCCRKWI TTETSVITQL FEGQLNYSIV CLKCEKCTYK 200
    NEVFTVLSLP IPSEYECSLQ DCLQCFFQQD TLTWNNQIHC SFCETKQETA 250
    VRAGISKAPK IIIFHLKRFD IQGTTKRKLR TDIHYPLTNL DLTPYICPIF 300
    RKYPKYNLCA VVNHFGDLDG GHYTAFCKNS FTQAWYSFDD TRVSEIPDTS 350
    VQNATAYLLF YSCQPFSIPI QKH 373
    Length:373
    Mass (Da):42,752
    Last modified:July 19, 2005 - v1
    Checksum:i09C80C792C8E4FE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB169252 mRNA. Translation: BAE01342.1.
    RefSeqiNP_001270928.1. NM_001283999.1.
    UniGeneiMfa.8509.

    Genome annotation databases

    GeneIDi101865081.
    KEGGimcf:101865081.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB169252 mRNA. Translation: BAE01342.1 .
    RefSeqi NP_001270928.1. NM_001283999.1.
    UniGenei Mfa.8509.

    3D structure databases

    ProteinModelPortali Q4R6D3.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.058.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101865081.
    KEGGi mcf:101865081.

    Organism-specific databases

    CTDi 373509.

    Phylogenomic databases

    HOVERGENi HBG098592.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
      International consortium for macaque cDNA sequencing and analysis
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiUBP50_MACFA
    AccessioniPrimary (citable) accession number: Q4R6D3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The human ortholog is inactive.

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3