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Q4R6D3 (UBP50_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative ubiquitin carboxyl-terminal hydrolase 50

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 50
Ubiquitin thioesterase 50
Ubiquitin-specific-processing protease 50
Gene names
Name:USP50
ORF Names:QtsA-18237
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Miscellaneous

The human ortholog is inactive.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Molecular functionHydrolase
Protease
Thiol protease
Gene Ontology (GO)
   Biological_processubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373Putative ubiquitin carboxyl-terminal hydrolase 50
PRO_0000249528

Regions

Domain44 – 364321USP

Sites

Active site531Nucleophile By similarity
Active site3221Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4R6D3 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 09C80C792C8E4FE4

FASTA37342,752
        10         20         30         40         50         60 
MTSQRSLPAD DFGIYYVLAE CTDYYDTLPV KEADGSQPCS QGVTGLRNLG NTCYMNAILQ 

        70         80         90        100        110        120 
CLCSISPLVE YFLSGKYITA LQNDCSEVAT AFAYLMTDMW LGDSDCVSPE IFRSALGNLY 

       130        140        150        160        170        180 
PAFTKKTQQD AQEFLIYVLN ELHEALKKYH YPRRRSHEKG SAQRCCRKWI TTETSVITQL 

       190        200        210        220        230        240 
FEGQLNYSIV CLKCEKCTYK NEVFTVLSLP IPSEYECSLQ DCLQCFFQQD TLTWNNQIHC 

       250        260        270        280        290        300 
SFCETKQETA VRAGISKAPK IIIFHLKRFD IQGTTKRKLR TDIHYPLTNL DLTPYICPIF 

       310        320        330        340        350        360 
RKYPKYNLCA VVNHFGDLDG GHYTAFCKNS FTQAWYSFDD TRVSEIPDTS VQNATAYLLF 

       370 
YSCQPFSIPI QKH 

« Hide

References

[1]"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
International consortium for macaque cDNA sequencing and analysis
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB169252 mRNA. Translation: BAE01342.1.
RefSeqNP_001270928.1. NM_001283999.1.
UniGeneMfa.8509.

3D structure databases

ProteinModelPortalQ4R6D3.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC19.058.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101865081.
KEGGmcf:101865081.

Organism-specific databases

CTD373509.

Phylogenomic databases

HOVERGENHBG098592.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP50_MACFA
AccessionPrimary (citable) accession number: Q4R6D3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries