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Q4R6D3

- UBP50_MACFA

UniProt

Q4R6D3 - UBP50_MACFA

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Protein

Putative ubiquitin carboxyl-terminal hydrolase 50

Gene

USP50

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei53 – 531NucleophilePROSITE-ProRule annotation
Active sitei322 – 3221Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.058.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ubiquitin carboxyl-terminal hydrolase 50 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 50
Ubiquitin thioesterase 50
Ubiquitin-specific-processing protease 50
Gene namesi
Name:USP50
ORF Names:QtsA-18237
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Putative ubiquitin carboxyl-terminal hydrolase 50PRO_0000249528Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ4R6D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 364321USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

HOVERGENiHBG098592.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4R6D3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSQRSLPAD DFGIYYVLAE CTDYYDTLPV KEADGSQPCS QGVTGLRNLG
60 70 80 90 100
NTCYMNAILQ CLCSISPLVE YFLSGKYITA LQNDCSEVAT AFAYLMTDMW
110 120 130 140 150
LGDSDCVSPE IFRSALGNLY PAFTKKTQQD AQEFLIYVLN ELHEALKKYH
160 170 180 190 200
YPRRRSHEKG SAQRCCRKWI TTETSVITQL FEGQLNYSIV CLKCEKCTYK
210 220 230 240 250
NEVFTVLSLP IPSEYECSLQ DCLQCFFQQD TLTWNNQIHC SFCETKQETA
260 270 280 290 300
VRAGISKAPK IIIFHLKRFD IQGTTKRKLR TDIHYPLTNL DLTPYICPIF
310 320 330 340 350
RKYPKYNLCA VVNHFGDLDG GHYTAFCKNS FTQAWYSFDD TRVSEIPDTS
360 370
VQNATAYLLF YSCQPFSIPI QKH
Length:373
Mass (Da):42,752
Last modified:July 19, 2005 - v1
Checksum:i09C80C792C8E4FE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB169252 mRNA. Translation: BAE01342.1.
RefSeqiNP_001270928.1. NM_001283999.1.
UniGeneiMfa.8509.

Genome annotation databases

GeneIDi101865081.
KEGGimcf:101865081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB169252 mRNA. Translation: BAE01342.1 .
RefSeqi NP_001270928.1. NM_001283999.1.
UniGenei Mfa.8509.

3D structure databases

ProteinModelPortali Q4R6D3.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C19.058.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101865081.
KEGGi mcf:101865081.

Organism-specific databases

CTDi 373509.

Phylogenomic databases

HOVERGENi HBG098592.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
    International consortium for macaque cDNA sequencing and analysis
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiUBP50_MACFA
AccessioniPrimary (citable) accession number: Q4R6D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 19, 2005
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The human ortholog is inactive.

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3