ID   DHSO_MACFA              Reviewed;         357 AA.
AC   Q4R639;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Sorbitol dehydrogenase;
DE            EC=1.1.1.14;
DE   AltName: Full=L-iditol 2-dehydrogenase;
GN   Name=SORD; ORFNames=QtsA-19202;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-iditol + NAD(+) = L-sorbose + NADH.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family.
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DR   EMBL; AB169351; BAE01436.1; -; mRNA.
DR   SMR; Q4R639; 1-356, 2-357.
DR   HOVERGEN; Q4R639; -.
DR   BRENDA; 1.1.1.14; 3438.
DR   GO; GO:0003939; F:L-iditol 2-dehydrogenase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013154; ADH_GroES-like.
DR   InterPro; IPR002085; ADH_SF_Zn.
DR   InterPro; IPR013149; ADH_Zn-bd.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   PANTHER; PTHR11695; ADH_Sf_Zn; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Metal-binding; NAD; Oxidoreductase; Zinc.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    357       Sorbitol dehydrogenase.
FT                                /FTId=PRO_0000231004.
FT   METAL        45     45       Zinc; catalytic (By similarity).
FT   METAL        70     70       Zinc; catalytic (By similarity).
FT   METAL        71     71       Zinc; catalytic (By similarity).
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
SQ   SEQUENCE   357 AA;  38206 MW;  4BB2278B107274CD CRC64;
     MAAAAKPKNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH YWEEGRIGNF
     IVKKPMVLGH EASGTVEKVG SLVKHLKPGD RVAIEPGVPR ENDEFCKSGR YNLSPSIFFC
     ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE EGALIEPLSV GIHACRRGGV TLGHRVLVCG
     AGPIGVVSLL VAKAMGAAQV VVTDLSAPRL SKAKEIGADL VLQISKESPQ EIAGKVEGLL
     GCKPEVTIEC TGAEASIQAG IYATRSGGTL VLVGLGSEMT TIPLLHAAVR EVDIKGVFRY
     CNTWPVAISM LASKSVNIKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC DPNDQNP
//