Q4R639 (DHSO_MACFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sorbitol dehydrogenase
EC=1.1.1.14

Alternative name(s):
L-iditol 2-dehydrogenase

Gene names

Name:	SORD
ORF Names:	QtsA-19202

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm By similarity.
Catalytic activity	L-iditol + NAD+ = L-sorbose + NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Mitochondrion membrane; Peripheral membrane protein. Cell projection › cilium › flagellum. Note: Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cell projection Cilium Flagellum Membrane Mitochondrion
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	sperm motility Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cilium Inferred from electronic annotation. Source: UniProtKB-KW flagellum Inferred from sequence or structural similarity. Source: UniProtKB mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-iditol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 357	356	Sorbitol dehydrogenase		PRO_0000231004
Sites
	Metal binding	45	1	Zinc; catalytic By similarity
	Metal binding	70	1	Zinc; catalytic By similarity
	Metal binding	71	1	Zinc; catalytic By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4R639 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 4BB2278B107274CD	FASTA	357	38,206
	10 20 30 40 50 60 MAAAAKPKNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH YWEEGRIGNF 70 80 90 100 110 120 IVKKPMVLGH EASGTVEKVG SLVKHLKPGD RVAIEPGVPR ENDEFCKSGR YNLSPSIFFC 130 140 150 160 170 180 ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE EGALIEPLSV GIHACRRGGV TLGHRVLVCG 190 200 210 220 230 240 AGPIGVVSLL VAKAMGAAQV VVTDLSAPRL SKAKEIGADL VLQISKESPQ EIAGKVEGLL 250 260 270 280 290 300 GCKPEVTIEC TGAEASIQAG IYATRSGGTL VLVGLGSEMT TIPLLHAAVR EVDIKGVFRY 310 320 330 340 350 CNTWPVAISM LASKSVNIKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC DPNDQNP

References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB169351 mRNA. Translation: BAE01436.1.
3D structure databases
ProteinModelPortal	Q4R639.
SMR	Q4R639. Positions 2-357.
ModBase	Search...
Proteomic databases
PRIDE	Q4R639.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG005484.
OrthoDB	EOG4WSW9S.
Family and domain databases
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSO_MACFA

Accession

Primary (citable) accession number: Q4R639

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 43 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program