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Q4R5Y2

- NADE_MACFA

UniProt

Q4R5Y2 - NADE_MACFA

Protein

Glutamine-dependent NAD(+) synthetase

Gene

NADSYN1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei357 – 3571PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi355 – 3628ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Source: InterPro
    3. NAD+ synthase (glutamine-hydrolyzing) activity Source: UniProtKB-EC

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, NAD, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00334.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine-dependent NAD(+) synthetase (EC:6.3.5.1)
    Alternative name(s):
    NAD(+) synthase [glutamine-hydrolyzing]
    NAD(+) synthetase
    Gene namesi
    Name:NADSYN1
    ORF Names:QtsA-19858
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 706706Glutamine-dependent NAD(+) synthetasePRO_0000237578Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ4R5Y2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 299295CN hydrolasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni325 – 706382LigaseBy similarityAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the NAD synthetase family.Curated
    Contains 1 CN hydrolase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG082007.
    KOiK01950.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.60.110.10. 1 hit.
    InterProiIPR003010. C-N_Hydrolase.
    IPR014445. Gln-dep_NAD_synthase.
    IPR022310. NAD/GMP_synthase.
    IPR003694. NAD_synthase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00795. CN_hydrolase. 1 hit.
    PF02540. NAD_synthase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006630. NADS_GAT. 1 hit.
    SUPFAMiSSF56317. SSF56317. 1 hit.
    TIGRFAMsiTIGR00552. nadE. 1 hit.
    PROSITEiPS50263. CN_HYDROLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4R5Y2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRKVTVATC ALNQWALDFE GNLQRILKSI EIAKNRGARY RLGPELEICG    50
    YGCWDHYYES DTLLHSFQVL AALLESPVTQ DIICDVGMPV MHRNVRYNCR 100
    VIFLSRKILL IRPKMALANE GNYRELRWFT PWSRSRHTEE YLLPRMIQDL 150
    TKQETAPFGD AVLATWDTCI GSEICEELWT PHSPHIDMGL DGVEIITNAS 200
    GSHHVLRKAN TRVDLVTMAT SKNGGIYLLA NQKGCDGDRL YYDGCAMIAM 250
    NGSVFAQGSQ FSLDDVEVLT ATLDLEDVRS YRAEISSRNL AASRASPYPR 300
    VKVDFALSCH EDLLAPVSEP IEWKYHSPEE EISLGPACWL WDFLRRSQQG 350
    GFLLPLSGGV DSAATACLVY SMCCQVCKSV RSGNQEVLAD VRTIVNQISY 400
    TPQDPRDLCG HILTTCYMAS KNSSQETCTR ARELAQQIGS HHISLNIDPA 450
    VKAVTGIFSL VTGKSPLFAA HGGSSRENLA LQNVQARIRM VLAYLFAQLS 500
    LWSRGIRGGL LVLGSANVDE SLLGYLTKYD CSSADINPIG GISKTDLRAF 550
    VQFCIERFQL TALQSIISAP VTAELEPLAD GQVSQTDEED MGMTYAELSV 600
    YGKLRKVAKM GPYSMFCKLL GMWRHVCTPR QVADKVKWFF TKHSMNRHKM 650
    TTLTPAYHAE NYSPEDNRFD LRPFLYNTSW PWQFRCIENQ VLQLERAAPQ 700
    SLDGVD 706
    Length:706
    Mass (Da):79,071
    Last modified:July 19, 2005 - v1
    Checksum:i1B3AF9BF3EF0523B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB169410 mRNA. Translation: BAE01493.1.
    RefSeqiNP_001270170.1. NM_001283241.1.
    UniGeneiMfa.7139.

    Genome annotation databases

    GeneIDi101926168.
    KEGGimcf:101926168.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB169410 mRNA. Translation: BAE01493.1 .
    RefSeqi NP_001270170.1. NM_001283241.1.
    UniGenei Mfa.7139.

    3D structure databases

    ProteinModelPortali Q4R5Y2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101926168.
    KEGGi mcf:101926168.

    Organism-specific databases

    CTDi 55191.

    Phylogenomic databases

    HOVERGENi HBG082007.
    KOi K01950.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00334 .

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.60.110.10. 1 hit.
    InterProi IPR003010. C-N_Hydrolase.
    IPR014445. Gln-dep_NAD_synthase.
    IPR022310. NAD/GMP_synthase.
    IPR003694. NAD_synthase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00795. CN_hydrolase. 1 hit.
    PF02540. NAD_synthase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006630. NADS_GAT. 1 hit.
    SUPFAMi SSF56317. SSF56317. 1 hit.
    TIGRFAMsi TIGR00552. nadE. 1 hit.
    PROSITEi PS50263. CN_HYDROLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
      International consortium for macaque cDNA sequencing and analysis
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiNADE_MACFA
    AccessioniPrimary (citable) accession number: Q4R5Y2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3