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Q4R5N9

- PPAL_MACFA

UniProt

Q4R5N9 - PPAL_MACFA

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Protein
Lysosomal acid phosphatase
Gene
ACP2, QccE-11805
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei42 – 421Nucleophile By similarity
Active sitei287 – 2871Proton donor By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal acid phosphatase (EC:3.1.3.2)
Short name:
LAP
Gene namesi
Name:ACP2
ORF Names:QccE-11805
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Lysosome membrane; Single-pass membrane protein; Lumenal side By similarity. Lysosome lumen By similarity
Note: The soluble form arises by proteolytic processing of the membrane-bound form By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 380350Lumenal Reviewed prediction
Add
BLAST
Transmembranei381 – 40121Helical; Reviewed prediction
Add
BLAST
Topological domaini402 – 42322Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lysosomal lumen Source: UniProtKB-SubCell
  3. lysosomal membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 By similarity
Add
BLAST
Chaini31 – 423393Lysosomal acid phosphatase
PRO_0000352521Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi133 – 1331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi159 ↔ 370 By similarity
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi212 ↔ 310 By similarity
Glycosylationi267 – 2671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi322 – 3221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi345 ↔ 349 By similarity

Post-translational modificationi

The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ4R5N9.

Structurei

3D structure databases

ProteinModelPortaliQ4R5N9.
SMRiQ4R5N9. Positions 31-371.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG002203.
KOiK14410.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4R5N9-1 [UniParc]FASTAAdd to Basket

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MAGKRSGWSR AALLQLLLGA NLMVMPPTQA RSLRFVTLLY RHGDRSPVKT    50
YPKDPYQEEE WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV 100
YVRSTDFDRT LMSAEANLAG LFPPNGMQRF NPNISWQPIP VHTVPITEDR 150
LLKFPLGPCP RYEQLQNETR KTPEYQNESS RNAQFLDMVA NETGLTDLTL 200
ETVWNVYDTL FCEQTHGLHL PPWASPQTMQ RLSRLKDFSF RFLFGIYQQA 250
EKARLQGGVL LAQIRRNLTL MATTSQLPKL LVYSAHDTTL VALQMALDVY 300
NGEQAPYASC HIFELYQEDS GNFSVEMYFR NESDKAPWPL SLPGCPHRCP 350
LQDFLHLTEP VVPKDWQQEC QLASGPADTE VIVALAVCGS ILFLLIVLLL 400
TVLFRMQAQP PGYRHVADGE DHA 423
Length:423
Mass (Da):48,310
Last modified:July 19, 2005 - v1
Checksum:i6835A18779B7B9B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB169504 mRNA. Translation: BAE01586.1.
RefSeqiXP_005578051.1. XM_005577994.1.
UniGeneiMfa.8272.

Genome annotation databases

GeneIDi101864829.
KEGGimcf:101864829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB169504 mRNA. Translation: BAE01586.1 .
RefSeqi XP_005578051.1. XM_005577994.1.
UniGenei Mfa.8272.

3D structure databases

ProteinModelPortali Q4R5N9.
SMRi Q4R5N9. Positions 31-371.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q4R5N9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101864829.
KEGGi mcf:101864829.

Organism-specific databases

CTDi 53.

Phylogenomic databases

HOVERGENi HBG002203.
KOi K14410.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
    International consortium for macaque cDNA sequencing and analysis
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiPPAL_MACFA
AccessioniPrimary (citable) accession number: Q4R5N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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